Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C1323099 (sympathomimetic)
 2,957 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study the effects of REN-293 have been examined on the rat tail artery "in situ'. It was found that the drug was totally dependent on the sympathetic nerves for its vasoconstrictor action. This action was blocked by phentolamine and attenuated by pre-treatment of the vessel with tyramine. When a comparative study of the vasoconstrictor effects of several sympathomimetics was performed, it was found that REN-293 was more potent than tyramine and ephedrine, but less so than etilefrine. It would appear that REN-293 is of interest as a pharmacological tool for examining sympathetic nerve function, but its usefulness in the therapy of orthostatic hypotension is likely to be limited, due to the very indirect nature of its sympathomimetic action.
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PMID:Vascular responses to REN-293 (2-amino-3[3, 5-dihydroxyphenyl]-1-propanol hydrochloride)--a new sympathomimetic agent. 611 28

The effect of several sympathomimetic agents on the efflux of noradrenaline and its metabolites has been evaluated using the ventral artery of the rat tail as the experimental model. This vessel is richly endowed with sympathetic nerves and is therefore well suited to examine the efflux patterns of that transmitter. Etilefrine, tyramine, ephedrine and REN-293 were all found to increase the efflux of 3H-noradrenaline and/or 3H-DOPEG to different degrees from the artery. Possible reasons for this variation in metabolite efflux are discussed.
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PMID:The effect of sympathomimetic agents on noradrenaline efflux from a blood vessel. 741 34