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Query: UMLS:C1275122 (TEM)
 21,810 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Changes were assessed in lymphocyte sub-populations in various stages of human pregnancy. The percentage and absolute number of E-RFC decreased during pregnancy. There was a concomitant rise in the percentages of EAC-RFC and cells bearing SmIg with little change in their absolute numbers. EAC-RFC continued to rise post-natally.
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PMID:Depletion of circulating T lymphocytes in pregnancy. 30 50

The percentage of T & B lymphocytes were estimated in 52 leprosy patients by 'E' and 'EAC' rosette techniques. The mean % values for 'T' lymphocytes were significantly lower in lepromatous group as compared with that of tuberculoid and borderline groups. Also, a significant difference was observed in the mean % values of T & B lymphocytes of the borderline and tuberculoid patients and of the normal control group. These findings were correlated with skin smears and lepromin testing.
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PMID:T & B lymphocytes in the spectrum of leprosy. 30 71

32 malignant solid tumours of various histological types were tested for the presence of Fc receptors, complement receptors and T-lymphocyte markers in single-cell suspensions of fresh tissue. Indicator cells were normal SRBC (E), SRBC coated with rabbit antisheep lg (EA) and EA coated with complement (EAC'). Fluorescent microscopy on tumour cells was done with rabbit anti-human IgG-fraction labeled with FITC. Almost all tumours possessed Fc receptors and/or complement-receptors. The presence of T-lymphocyte marker was less frequently found. It is proposed to establish a "receptor classification" in addition to the histologic classification of the tumours.
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PMID:[Receptors for complement and Fc and T-lymphocyte markers on cells of malignant tumours of man (author's transl)]. 30 90

We used the membrane fluorescence and the rosette formation test to study the lymphocyte populations in 25 patients with untreated chronic lymphocytic leukemia (CLL). The results show a significant increase, absolute and percent of S-Ig bearing cells, whereas the E and EA rosette forming cells are decreased in per cent, increased in absolute. The number of lymphocytes with the receptor for the Fc fragment of IgG, is unchanged. The lymphocytosis causes mainly a significant decrease in percentage of E rosette forming cells. A big splenomegaly and a bad clinical stage, according to Rai et al. classification, are responsible for a decrease of E, EA, EAC rosette forming cells; unchanged the percentage of S-Ig bearing cells. Such a modification of the surface receptor pattern is present not only in those CLL more advanced in clinical stage and with hyperleucocitosis and/or splenomegaly, but also in those forms with worse clinical feature and prognosis. Our work confirms that CLL is mainly a B proliferative disease; we observed only one case due to T cell proliferation. Four cases were impossible to classify immunologically: one had no cells bearing the markers, three had a subnormal surface receptor pattern.
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PMID:[Lymphocyte typing in chronic lymphoid leukemia]. 30 12

A case of typical immunoblastic lymphadenopathy is described. Cell surface marker studies were performed on mononuclear isolates from peripheral blood, ascitic fluid and a lymph node biopsy and the results correlated with light microscopic findings. These data indicated that the majority of the cells in the lymph node were of T cell origin. A smaller percentage of cells could be recognized as deriving from the B cell line and it may have contained a monoclonal subpopulation. Some immunoblasts formed E rosettes and could be identified as T cells but most did not form E or EAC rosettes or bear SmIg and could not be identified as B cells. There was an associated marked increase in mononuclear phagocytes in both ascites and peripheral blood. This disease entity may represent a dual proliferation of cells originating from both B and T cell compartments with T cells predominating in the lymph node in this case.
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PMID:Immunoblastic lymphadenopathy. A mixed proliferation of T and B lymphocytes. 30 52

Cells bearing surface immunoglobulins (Ig+-cells) detected by the indirect immunofluorescent method and cells forming rosettes (RFC) with sheep erythrocytes coated with antibody and complement (EAC rosettes) were found in the liver and the spleen on the 15th and the 20th days of prenatal life of rats. The percentage of Ig+-cells and RFC in the liver was high and remained unchanged and at about the same level during the whole postnatal life. The spleen and the bone marrow displayed an increase of the Ig+-cells and RFC increased throughout the 1st month of postnatal life with the maximum at the 30th day after birth; a sharp decrease occurred in old animals. In the thymus the Ig+-cells and the RFC were either absent or present in very small amounts only at some periods of study. Ig+-cells with "capping" were discovered in the spleen and bone marrow on the 5th--10th days of postnatal life; their count increased considerably in 30-day and adult rats. Such cells were absent in the lymphoid tissues of old 40-month rats.
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PMID:[Properties and kinetics of a population of B-lymphocytes during rat ontogenesis]. 30 26

The immunocytological identification of the mycosis fungoides cell was carried out on cells extracted from the tumorous nodules of a patient suffering from typical mycosis fungoides. Various techniques, such as E and IgM-EAC rosettes and examination for surface membrane immunoglobulins, were performed on the peripheral blood cells and the tumour cell. Membrane staining with a specific anti-T lymphocyte serum conjugated with peroxidase confirmed the thymodependent origin of the mycosis fungoides cell. However, the immunolabelling (with Fab peroxidase conjugate was found constantly negative.
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PMID:Immunocytological characterization of the mycosis fungoides tumour cell. 30 33

Myelin basic protein (BP),induces an increased in vitro proliferative response of peritoneal exudate cells (PEC), compared with that given by pheripheral blood lymphocytes (PBL), in guinea-pigs with experimental allergic encephaloMYELITIS (EAE). This response is determined by the nature of the lymphocytes in such exudates. We have also found that: (a) the majority of peritoneal lymphocytes from non-sensitized animals are E-rosetting (T cells) (59 percent) or null cells (greater than 40 percent) with EAC-rosetting (B cells) comprising 1 percent or less of cells; (b) both T cells and null cells respond equally to BP as determined by a technique combining rosette-formation and autoradiography; (c) the increased in vitro peritoneal lymphocyte response in animals with EAE cannot be explained solely by the number of null cells since peripheral blood and lymph nodes also contain appreciable numbers of null cells.
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PMID:Reactive and non-reactive lymphocytes in experimental allergic encephalomyelitis. 30 29

The distribution of thymus-derived (T) and bone marrow-derived (B) lymphocytes in 100 patients with psoriasis were studied by the rosetting techniques. Depression of the number of T lymphocytes forming spontaneous rosettes with sheep erythrocytes (E rosettes) occurred in 66% of patients, whereas no difference in B lymphocytes bearing C3 receptor (EAC rosettes) was observed between psoriatics and normals. The decrease in E rosettes was associated with the active phase of the disease. This disappeared 4-6 wk after onset of remission, which suggested that the abnormality in T-cell marker distribution is transitional. Lymphocytes forming neither E nor EAC rosettes, which were found to be significantly increased in active psoriasis, were identified as T lymphocytes since they reacquired normal E rosette function during short-term preincubation with concanavalin A (Con A). A serum factor was also demonstrated which inhibited E rosette formation by normal peripheral blood lymphocytes. Its activity increased linearly within 2 mo from the onset of skin lesions. The data suggest that in active psoriasis serum factors may be coated on the lymphocyte surface membrane which may be responsible for blocking of specific receptor for sheep erythrocytes and/or interfere with T lymphocyte function.
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PMID:Defective function of T lymphocytes in psoriasis. 30 65

Mononuclear cells from seven patients with hairy cells leukaemia were examined for features suggestive of either a lymphocytic or monocytic origin. Immunofluorescent staining of both methanol fixed and incubated cells, using monospecific antisera, revealed a predominant cell-associated immunoglobulin in each case. Three were positive for mu and kappa chains, two for gamma and kappa chains, one for delta and kappa chain determinants and one reacted only with antigamma chain serum. Formation of EAC rosettes, a feature of both B lymphocytes and monocytes, was variable. T cells, as judged by E rosettes, were not elevated in any patient. Phytohaemagglutinin reactivity was normal in six and depressed in one case. With the exception of minimal activity in assays for glass adherence and latex particle phagocytosis, none of the cells showed features typical of monocytes. Hairy cells were negative by peroxidase stain and lacked the electron microscopic characteristics of monocytes. They did not react in either rosette or phagocytic assays with anti-A or anti-D coated erythrocytes nor did they elaborate granulocyte colony stimulating factor, a monocyte-derived in vitro granulopoietin. Although unequivocal classification of these abnormal cells is not possible, the data storngly suggests that this represents a variant of a B lymphocytic neoplasm.
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PMID:Hairy cell leukaemia: seven cases with probable B-lymphocytic origin. 30 39


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