Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C1261473 (sarcoma)
 25,952 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients suffering from soft tissue sarcoma of the extremities may sometimes require vascular reconstruction to remove the tumor with adequate margins of clearance. Besides this, recurrent lymph node metastases are often affixed to neighboring vessels. MRI and angiography represent the adequate diagnostic procedures. Vessel-invasive sarcoma can hardly be treated by surgical resection with curative intent alone. If there is doubt about invasion of arteries and veins, the vessels should be resected and replaced by autologous vein graft. Soft tissue coverage is of major importance, particularly if prosthetic grafts are used or the resection is within an area of irradiated tissue. After radical resection and combined modality therapy, one can expect local recurrence rates similar to those without vessel invasion. To achieve this goal, surgical oncologists, vascular surgeons and plastic surgeons must work together. Today, amputation can hardly be justified even in vessel-invasive soft tissue tumors.
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PMID:[Surgical technique and surgical-oncologic tactics in tumors of soft tissues and extremities with vascular involvements]. 952 66

We report a case of alveolar soft part sarcoma (ASPS) of the thigh with lung metastases in a 22-year-old woman. The findings of digital subtraction angiography (DSA) and MRI contributed to the diagnosis of ASPS. Especially dynamic contrast-enhanced MRI was useful for evaluating the effect of chemoembolotherapy.
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PMID:Alveolar soft part sarcoma. 960 70

We performed a retrospective analysis to evaluate the ability of whole-body F-fluorodeoxyglucose positron emission tomography (FDG PET) to identify local recurrence and pulmonary metastases in patients with soft-tissue tumours after treatment. We compared the results of FDG PET with those of MRI for the detection of local recurrence, and with CT of the chest for pulmonary metastases. We assessed 62 patients of mean age 51 years, who had 15 types of soft-tissue sarcoma, after a mean follow-up of 3 years 2 months. For the detection of local disease, 71 comparisons showed that the sensitivity and specificity of FDG PET were 73.7% and 94.3%, respectively; there were 14 true-positive and five false-negative results. MRI had a sensitivity and specificity of 88.2% and 96.0% respectively. For the identification of lung metastases, 70 comparisons showed that the sensitivity and specificity of FDG PET were 86.7% and 100%, with 13 true-positive results and two false-negative results. CT of the chest had a sensitivity and specificity of 100% and 96.4%. Thirteen other sites of metastases were identified by FDG PET. FDG PET can identify both local and distant recurrence of tumour as a one-step procedure and will detect other metastases. It seems that all three methods of imaging are needed to define accurately the extent of disease, both at initial staging and during follow-up.
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PMID:Evaluation of fluorodeoxyglucose positron emission tomography in the management of soft-tissue sarcomas. 961 33

Malignant fibrous histiocytoma (MFH) is a rare and potentially highly malignant sarcoma. The authors report 6 cases of MFH in various sites: two in the chest wall, one in the pelvis, two in the gluteal zones and one on the scalp. Ultrasonography and computed tomography were the main imaging methods used in the assessment of the structure and extension of the tumor. A poor prognosis was noted in four cases: death within a few months in the two thoracic sites, recurrence in the pelvic and scalp lesions, radical surgery allowed recovery in two cases. A review of the literature showed that MRI and CT are complementary in the initial staging and follow-up of these patients.
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PMID:[Value of imaging in the assessment of malignant fibrous histiocytoma of the soft tissues]. 963 79

Treosulfan (L-threitol-1,4-bismethanesulfonate, Ovastat) was tested on human renal tumor cells growing as xenografts in athymic nude mice and as monolayers in vitro, in comparison with clinically used cytostatic drugs (in vivo, cyclophosphamide, vinblastine, and 5-fluorouracil; in vitro, vinblastine and 5-fluoro-2'-deoxyuridine) which were administered at equitoxic or equivalent dose levels, respectively. Four human renal tumor xenografts (N-U 2, N-U 26, MRI-H 121, KTCTL-1M) were investigated in vivo, and seven renal tumor cell lines (KTCTL-1M, KTCTL-2, KTCTL-26A, KTCTL-30, KTCTL-84, MRI-H 121, N-U 2) under in vitro conditions. The investigations of the four human renal tumor xenografts revealed that treosulfan is capable of inducing pronounced growth inhibitions ranging from 60-100% in comparison with untreated control tumors. In the xenografted renal-cell carcinoma KTCTL-1M, treosulfan administered at the highest dose level (1 x 3,500 mg/kg) even effected a complete remission lasting for more than three weeks in all animals treated with this dose. It was more effective in the N-U 2 carcinoma growing in vivo than the comparative compounds cyclophosphamide and vinblastine. In the heterotransplanted renal-cell carcinoma N-U 26, treosulfan showed a similar activity as the two established cytostatic drugs tested whereas, in the renal sarcoma MRI-H 121, both cyclophosphamide and vinblastine were slightly more effective than treosulfan. In four renal-cell carcinomas growing as monolayers in vitro (KTCTL-1M, KTCTL-2, KTCTL-84, N-U 2), treosulfan induced cell growth inhibitions by about 50% at peak plasma concentration in comparison with untreated control cultures. The IC50 values ranged from 5 x 10(-6) to 10(-4) mol/l in all seven monolayer cultures investigated 5-Fluoro-2'-deoxyuridine (floxuridine) was similarly active in vitro as treosulfan with respect to the molar concentrations inducing growth inhibition and to the IC50 values, whereas vinblastine was more effective than treosulfan in most of the human renal tumor cell monolayers investigated. These results reveal the remarkable antitumor efficacy of treosulfan towards human renal-cell carcinomas, especially under in vivo conditions. This activity was similarly high or even better than in cyclophosphamide and vinblastine. The in vitro data obtained in monolayer cultures also confirmed the remarkable antiproliferative activity of treosulfan in renal tumor cells, but did not mirror very well the pattern of antitumor activity observed in vivo.
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PMID:The alkylator treosulfan shows activity towards human renal-cell carcinoma in vivo and in vitro. 970 71

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in adults. This pictorial essay describes and illustrates the clinical, pathologic, and radiologic features of MFH. The cross-sectional imaging features on CT and MRI are emphasized in relation to the diagnosis and staging of MFH.
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PMID:Malignant fibrous histiocytoma of soft tissue imaging with emphasis on MRI. 975 24

A case of malignant melanoma of the quadriceps tendon is reported. This is an uncommon soft tissue sarcoma of melanocytic origin. The appearance on MRI depends on its melanin content. The microscopic appearance is distinctive and prognosis is poor. This tumor should be kept in mind when a nodular lesion is detected in specific tendon or aponeurosis.
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PMID:[Malignant melanoma of soft tissues. Apropos of a case]. 975 9

A case of an intraarticular epithelioid sarcoma is presented. The patient was a 35 year old man who presented with a 10 months history of a chronic monoarthritis. The MRI showed a diffuse lesion involving the synovial membrane of the knee. There was a marked increased signal on T2 weighted images. Most epithelioid sarcomas involve the subcutaneous tissues of the hands or feet. This presentation is unusual and this entity should be considered in the differential diagnosis of an intraarticular proliferative process.
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PMID:Intraarticular epithelioid sarcoma. 976 40

Two cases of calvarium sarcoma with intracranial extension, consecutive to Paget disease of the skull are presented. The neurosurgical implications of this rare complication of a common disease are reviewed. In both cases, the symptoms of malignant degeneration were unspecific and blurred by the presence of a well-known Paget disease. Increasing headaches, focal neurological deficits and signs of intracranial hypertension were observed. Skull X-rays and Computerised Tomography did not allow to make the difference between Pagetic bone and sarcoma. In the second case, Magnetic Resonance Imaging was the most accurate in determining the precise localisation of the tumour, and the subdural invasion. Extensive surgical resection was carried out, by craniectomy of the tumoural bone, followed by cranioplasty. Dural sinus involvement and tumour hypervascularisation caused important peroperative blood loss in both patients. In the second case, the tumour invaded the subdural space through a Pacchioni granulation. Survival of patients with Pagetic sarcoma seems shorter when compared to post-radiation or primitive osteosarcoma, despite adjuvant therapies, probably because of late diagnosis and incomplete surgical resection. The mean reported survival rate is 6 months. Although the first patient died within 4 months, in the second case, the authors obtained a more than two year survival with aggressive surgery alone. These cases also illustrate the polymorphism of sarcomatous degeneration of Pagetic calvarium, the interest of MRI, and the need for close surveillance of patients with known Pagets disease of the skull.
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PMID:Pagetic sarcoma of the calvarium: report of two cases. 992 24

Soft-tissue masses present a challenge to the practicing physician. Most are of little or no concern and do not need medical attention, but the consequences of missing a sarcoma are significant. It is important to give careful consideration to each soft-tissue mass seen and decide which need further evaluation and which do not. Periodic reexamination is recommended for patients with masses not thought to need biopsy. Patients with more worrisome soft-tissue masses should have at least an MRI scan and then, usually, a biopsy.
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PMID:Evaluation of soft-tissue tumors. 1009 91


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