Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1175175 (
SARS
)
19,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Spike and nucleocapsid proteins of
severe acute respiratory syndrome
coronavirus 2 (
SARS
-CoV-2-SP,
SARS
-CoV-
2-NP
) are the main immunogenic targets for antibodies. We herein demonstrate that the glycosylation of
SARS
-CoV-
2-NP
masks some of its antibody epitopes. In many cases, this can lead to false-negative serological tests. Deglycosylation of
SARS
-CoV-
2-NP
significantly increased the number of positive tests. The glycosylation pattern analysis of this protein revealed that the putative N-linked glycosylation sites, at the amino acid positions 48 and 270, co-located with two of the main immunodominant B cell epitopes.
...
PMID:Dual ELISA using SARS-CoV-2 nucleocapsid protein produced in E. coli and CHO cells reveals epitope masking by N-glycosylation. 3327 51
