Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1175175 (
SARS
)
19,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
3CL
pro
is the main protease of the novel coronavirus (
SARS
-CoV-2) responsible for their intracellular duplication. Based on virtual screening technology and molecular dynamics simulation, we found 23 approved clinical drugs such as Viomycin,
Capastat
, Carfilzomib and Saquinavir, which showed high affinity with the 3CL
pro
active sites. These findings showed that there were potential drugs that inhibit
SARS
-Cov-2's 3CL
pro
in the current clinical drug library, and these drugs can be further tested or chemically modified for the treatment of COVID-19. Communicated by Ramaswamy H. Sarma.
...
PMID:Virtual screening of approved clinic drugs with main protease (3CL
pro
) reveals potential inhibitory effects on SARS-CoV-2. 3290 28
