Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C1140680 (
ovarian cancer
)
28,141
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Previous studies have reported that intracellular Ca
2+
signals and inducible nitric oxide synthase (iNOS) are involved in cell apoptosis. However, the role of iNOS in cisplatin resistance in
ovarian cancer
remains unclear. Here, we demonstrate that SKOV3/DDP
ovarian cancer
cells were more resistant to cisplatin than were SKOV3
ovarian cancer
cells. The expression of intracellular Ca
2+
and iNOS was more strongly induced by cisplatin in SKOV3 cells than in SKOV3/DDP cells. TAT-conjugated IP3R-derived peptide (TAT-
IDP
S
) increased cisplatin-induced iNOS expression and apoptosis in SKOV3/DDP cells. 2-Aminoethoxydiphenyl borate (2-APB) decreased cisplatin-induced iNOS expression and apoptosis in SKOV3 cells. Thus, iNOS induction may be a valuable strategy for improving the anti-tumor efficacy of cisplatin in
ovarian cancer
.
...
PMID:Increased intracellular Ca
2+
decreases cisplatin resistance by regulating iNOS expression in human ovarian cancer cells. 2793 94
