Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C1140680 (
ovarian cancer
)
28,141
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Using a systems biology approach to prioritize potential points of intervention in
ovarian cancer
, we identified the lysine rich coiled-coil 1 (
KRCC1
), as a potential target. High-grade serous
ovarian cancer
patient tumors and cells express significantly higher levels of
KRCC1
which correlates with poor overall survival and chemoresistance. We demonstrate that
KRCC1
is predominantly present in the chromatin-bound nuclear fraction, interacts with HDAC1, HDAC2, and with the serine-threonine phosphatase PP1CC. Silencing
KRCC1
inhibits cellular plasticity, invasive properties, and potentiates apoptosis resulting in reduced tumor growth. These phenotypes are associated with increased acetylation of histones and with increased phosphorylation of H2AX and CHK1, suggesting the modulation of transcription and DNA damage that may be mediated by the action of HDAC and PP1CC, respectively. Hence, we address an urgent need to develop new targets in cancer.
...
PMID:KRCC1: A potential therapeutic target in ovarian cancer. 3190 25
