Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0948265 (metabolic syndrome)
24,271 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 8992
HDL 1727
Sep 1403
adiponectin 1208
leptin 1120
Mol 991
C-reactive protein 811
gut 723
ATP 554
cytokine 414
tumor necrosis factor 373
TNF 369
renin 346
adipokine 318
IL-6 306
peroxisome proliferator-activated receptor 304
hemoglobin 286
Adiponectin 261
peroxisome proliferator-activated receptor gamma 250
CRP 232
interleukin-6 225
albumin 216
AMP-activated protein kinase 200
endoplasmic reticulum 199
glucagon 191
insulin receptor 181
alanine aminotransferase 177
angiotensin II 177
resistin 177
fibrinogen 174
HSD1 170
Leptin 166
plasminogen activator inhibitor-1 163
PPAR 162
apolipoprotein B 157
collagen 144
superoxide dismutase 140
ghrelin 137
epididymal 136
IRS-1 131
Men 128
apolipoprotein 126
nuclear receptor 124
AMPK 123
SBP 114
aspartate aminotransferase 109
lipopolysaccharide 105
glucocorticoid receptor 104
mTOR 98
ACE 98
lipoprotein lipase 98
TNF-alpha 95
nitric oxide synthase 95
catalase 95
glucose transporter 94
insulin-like growth factor 90
growth hormone 88
DBP 86
angiotensin receptor 86
visfatin 84
sex hormone-binding globulin 83
fatty acid synthase 82
IL-10 78
histone 78
TLR4 77
MCP-1 77
PI3K 76
MAPK 75
ROS 74
ferritin 73
AKT 72
AST 72
JNK 72
mineralocorticoid receptor 72
reductase 71
leptin receptor 70
GLUT4 67
AMP 66
endothelial nitric oxide synthase 65
PGC 65
more...
Disease
metabolic syndrome 24271
obesity 10003
diabetes 7253
hypertension 5145
type 2 diabetes 4303
cardiovascular disease 3997
dyslipidemia 2742
atherosclerosis 1832
fatty liver 1592
cancer 1361
glucose intolerance 1172
hyperglycemia 1131
abdominal obesity 1100
Nonalcoholic fatty liver 898
hyperlipidemia 831
hyperinsulinemia 782
cirrhosis 723
stroke 665
coronary heart disease 661
coronary artery disease 608
liver disease 605
alcoholic fatty liver 529
hepatocellular carcinoma 523
polycystic ovary syndrome 431
depression 426
heart failure 394
hypercholesterolemia 371
myocardial infarction 368
renal disease 368
hyperuricemia 343
schizophrenia 340
chronic liver disease 329
psoriasis 295
tumor 282
osteoporosis 274
obstructive sleep apnea 256
Alzheimer's disease 251
HIV 234
plaque 231
heart disease 218
vascular disease 209
prediabetes 206
hypogonadism 203
metabolic disorder 198
myocardial ischemia 197
chronic disease 189
ischemia 185
microalbuminuria 184
cognitive impairment 184
prostate cancer 184
breast cancer 183
gestational diabetes mellitus 176
gout 172
malnutrition 172
erectile dysfunction 168
liver fibrosis 163
type 1 diabetes 157
essential hypertension 153
dementia 152
hepatitis C 151
lipodystrophy 143
sleep apnea 142
atherosclerotic cardiovascular disease 138
hyperandrogenism 136
Syndrome 134
infertility 129
rheumatoid arthritis 129
cardiovascular risk factor 125
hyperphagia 123
arthritis 122
renal failure 121
inflammatory bowel disease 119
proteinuria 119
vitamin D deficiency 118
osteoarthritis 115
diabetic nephropathy 115
overnutrition 114
mental illness 108
carcinogenesis 107
ventricular hypertrophy 100
more...
Symptom
overweight 1237
pain 133
fatigue 97
cachexia 69
angina 57
starvation 52
sleepiness 48
hepatomegaly 36
hunger 36
weakness 32
anorexia 27
diarrhea 26
insomnia 26
seizures 25
exhaustion 25
snoring 23
anesthesia 21
constipation 18
respiratory distress 16
headache 16
hot flashes 14
collapse 13
menopausal symptoms 13
Depressive symptoms 13
vomiting 12
nausea 12
flushing 10
polydipsia 10
chest pain 10
acute stress 9
discomfort 9
discomfort 9
hypothermia 9
hypercapnia 9
masculinization 9
memory loss 8
dyspnea 8
myalgia 8
polyuria 8
hypotonia 7
acidity 7
vertigo 6
dystonia 6
abdominal pain 6
hot flushes 6
lethargy 5
cough 5
arthralgia 5
functional recovery 5
erythema 4
Catch 4
back pain 4
enuresis 4
eds 4
peri-menopausal 4
splenomegaly 4
apathy 4
tinnitus 4
hypersomnia 4
hepatosplenomegaly 4
knee pain 3
ataxia 3
abdominal discomfort 3
thinning 3
autodigestion 3
dizziness 3
night sweats 3
spasm 3
shortness of breath 3
cyanosis 3
Lower urinary tract symptoms 3
pelvic pain 3
ketonuria 3
tremor 3
regurgitation 3
asthenia 3
hyperoxia 2
nausea and vomiting 2
exertional angina 2
female puberty 2
more...
Drug
Cardiovasc 375
Dermatol 171
Fructose 128
niacin 111
vitamin E 106
ROS 74
ascorbate 59
ADM 48
lysine 44
ROC 44
caffeine 39
EPA 37
Bifidobacterium 35
Rimonabant 32
Monit 28
Glucagon 23
Angiotensin II 23
Growth hormone 22
Growth hormone 21
Leaf 19
NADH 19
Rosiglitazone 19
Ezetimibe 19
ALA 19
Simvastatin 18
Rosuvastatin 18
MAP 16
IL-2 15
Vitamin A 15
Bezafibrate 15
Orlistat 14
Estrogens 14
Vitamin E 13
ABC 13
Spectrum 12
Asthma 11
citric acid 11
Nitric Oxide 11
Dial 10
Kenyan 10
Olmesartan 10
nitroglycerin 10
Check 10
Valsartan 9
Albumin 9
CSF 9
Glutathione 8
Nebivolol 8
Heme 8
Olive oil 8
EE2 8
lactose 7
HCH 7
PTH 7
Nephron 7
BH4 7
Portal 6
VCR 6
Aloe 6
Pravastatin 6
p75 6
Captopril 6
Aliskiren 5
Ethanol 5
Glycyrrhiza 5
Febuxostat 5
Troglitazone 5
Lovastatin 5
Ramipril 5
Ginseng 5
NAH 5
AHF 5
Wine 5
CCL 5
IFN-gamma 4
Android 4
Indomethacin 4
DM1 4
TAK 4
Creosote 4
more...
Enzyme
renin 346
alanine aminotransferase 315
AMP-activated protein kinase 306
mitogen-activated protein kinase 223
aspartate aminotransferase 178
superoxide dismutase 165
ACE 141
protein kinase 140
AMPK 123
AMPK 123
catalase 107
ERK 106
lipoprotein lipase 98
NADPH oxidase 92
11beta-hydroxysteroid dehydrogenase 86
gamma-glutamyl transpeptidase 78
NADPH oxidase 78
AST 73
lipase 70
acetyl-CoA carboxylase 58
focal adhesion kinase 58
NO synthase 55
glutathione peroxidase 53
luciferase 51
xanthine oxidase 48
peroxidase 44
protein kinase C 42
alkaline phosphatase 41
phosphoenolpyruvate carboxykinase 41
phosphodiesterase 40
phospholipase A2 39
LPL 37
ATPase 33
calcineurin 32
phosphatidylinositol 3-kinase 30
CPT 30
phosphoenolpyruvate carboxykinase 29
phosphoenolpyruvate carboxykinase 29
tissue plasminogen activator 28
creatine kinase 28
prostate-specific antigen 27
glucokinase 27
hormone-sensitive lipase 26
HSD 24
thrombin 24
alpha-glucosidase 23
paraoxonase 23
caspase-1 23
paraoxonase 22
glucose-6-phosphatase 22
reverse transcriptase 22
CAD 21
CAD 21
CAD 21
heme oxygenase 21
aldehyde dehydrogenase 20
ACS 20
proteasome 20
soluble epoxide hydrolase 19
3-hydroxy-3-methylglutaryl coenzyme A reductase 19
glutathione reductase 19
caspase-3 18
CYP7A1 18
NOS 17
lactate dehydrogenase 17
methylenetetrahydrofolate reductase 17
methylenetetrahydrofolate reductase 17
fructokinase 16
GSK 16
acetylcholinesterase 15
phosphoinositide 3-kinase 15
ketohexokinase 15
glucose-6-phosphate dehydrogenase 15
CPT 14
CPT 14
MAP 14
IKK 14
cholinesterase 14
complex I 13
guanylate cyclase 13
more...
Compound
glucose 6076
Clin 2057
Dec 1648
Insulin 1047
Cholesterol 745
oxygen 629
Cardiol 563
ATP 554
water 508
DNA 457
calcium 396
TNF 369
nitric oxide 363
creatinine 277
vitamin D 274
sodium 269
aldosterone 243
salt 171
acetate 153
phosphate 144
iron 141
silver 139
homocysteine 132
Fructose 128
ethanol 123
Diabetol 115
Metformin 112
Metformin 112
Diabetol 112
arginine 105
potassium 104
Testosterone 99
Pac 99
Testosterone 98
methionine 96
nitrogen 95
DBP 87
PMA 87
DBP 87
tyrosine 85
hydrogen 84
zinc 83
urea 82
AMP 79
Vitamin D 78
serine 75
nicotinic acid 73
palmitic acid 68
Uric acid 67
CoA 61
alanine 60
NAD 60
palmitic acid 59
glycerol 57
GSH 57
GSH 57
glutamate 56
nicotinic acid 56
nicotinic acid 55
nicotinic acid 55
cAMP 54
AHA 54
DHA 52
leucine 52
lysine 51
retinol 51
nitrate 50
Angiotensin II 50
copper 50
NADPH 47
NADPH 47
selenium 47
Androgen 46
Resveratrol 45
NAD 45
cysteine 45
sulfate 45
threonine 44
nicotinamide 42
Melatonin 40
more...