Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0948265 (
metabolic syndrome
)
24,271
document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
insulin
8992
HDL
1727
Sep
1403
adiponectin
1208
leptin
1120
Mol
991
C-reactive protein
811
gut
723
ATP
554
cytokine
414
tumor necrosis factor
373
TNF
369
renin
346
adipokine
318
IL-6
306
peroxisome proliferator-activated receptor
304
hemoglobin
286
Adiponectin
261
peroxisome proliferator-activated receptor gamma
250
CRP
232
interleukin-6
225
albumin
216
AMP-activated protein kinase
200
endoplasmic reticulum
199
glucagon
191
insulin receptor
181
alanine aminotransferase
177
angiotensin II
177
resistin
177
fibrinogen
174
HSD1
170
Leptin
166
plasminogen activator inhibitor-1
163
PPAR
162
apolipoprotein B
157
collagen
144
superoxide dismutase
140
ghrelin
137
epididymal
136
IRS-1
131
Men
128
apolipoprotein
126
nuclear receptor
124
AMPK
123
SBP
114
aspartate aminotransferase
109
lipopolysaccharide
105
glucocorticoid receptor
104
mTOR
98
ACE
98
lipoprotein lipase
98
TNF-alpha
95
nitric oxide synthase
95
catalase
95
glucose transporter
94
insulin-like growth factor
90
growth hormone
88
DBP
86
angiotensin receptor
86
visfatin
84
sex hormone-binding globulin
83
fatty acid synthase
82
IL-10
78
histone
78
TLR4
77
MCP-1
77
PI3K
76
MAPK
75
ROS
74
ferritin
73
AKT
72
AST
72
JNK
72
mineralocorticoid receptor
72
reductase
71
leptin receptor
70
GLUT4
67
AMP
66
endothelial nitric oxide synthase
65
PGC
65
more...
Disease
metabolic syndrome
24271
obesity
10003
diabetes
7253
hypertension
5145
type 2 diabetes
4303
cardiovascular disease
3997
dyslipidemia
2742
atherosclerosis
1832
fatty liver
1592
cancer
1361
glucose intolerance
1172
hyperglycemia
1131
abdominal obesity
1100
Nonalcoholic fatty liver
898
hyperlipidemia
831
hyperinsulinemia
782
cirrhosis
723
stroke
665
coronary heart disease
661
coronary artery disease
608
liver disease
605
alcoholic fatty liver
529
hepatocellular carcinoma
523
polycystic ovary syndrome
431
depression
426
heart failure
394
hypercholesterolemia
371
myocardial infarction
368
renal disease
368
hyperuricemia
343
schizophrenia
340
chronic liver disease
329
psoriasis
295
tumor
282
osteoporosis
274
obstructive sleep apnea
256
Alzheimer's disease
251
HIV
234
plaque
231
heart disease
218
vascular disease
209
prediabetes
206
hypogonadism
203
metabolic disorder
198
myocardial ischemia
197
chronic disease
189
ischemia
185
microalbuminuria
184
cognitive impairment
184
prostate cancer
184
breast cancer
183
gestational diabetes mellitus
176
gout
172
malnutrition
172
erectile dysfunction
168
liver fibrosis
163
type 1 diabetes
157
essential hypertension
153
dementia
152
hepatitis C
151
lipodystrophy
143
sleep apnea
142
atherosclerotic cardiovascular disease
138
hyperandrogenism
136
Syndrome
134
infertility
129
rheumatoid arthritis
129
cardiovascular risk factor
125
hyperphagia
123
arthritis
122
renal failure
121
inflammatory bowel disease
119
proteinuria
119
vitamin D deficiency
118
osteoarthritis
115
diabetic nephropathy
115
overnutrition
114
mental illness
108
carcinogenesis
107
ventricular hypertrophy
100
more...
Symptom
overweight
1237
pain
133
fatigue
97
cachexia
69
angina
57
starvation
52
sleepiness
48
hepatomegaly
36
hunger
36
weakness
32
anorexia
27
diarrhea
26
insomnia
26
seizures
25
exhaustion
25
snoring
23
anesthesia
21
constipation
18
respiratory distress
16
headache
16
hot flashes
14
collapse
13
menopausal symptoms
13
Depressive symptoms
13
vomiting
12
nausea
12
flushing
10
polydipsia
10
chest pain
10
acute stress
9
discomfort
9
discomfort
9
hypothermia
9
hypercapnia
9
masculinization
9
memory loss
8
dyspnea
8
myalgia
8
polyuria
8
hypotonia
7
acidity
7
vertigo
6
dystonia
6
abdominal pain
6
hot flushes
6
lethargy
5
cough
5
arthralgia
5
functional recovery
5
erythema
4
Catch
4
back pain
4
enuresis
4
eds
4
peri-menopausal
4
splenomegaly
4
apathy
4
tinnitus
4
hypersomnia
4
hepatosplenomegaly
4
knee pain
3
ataxia
3
abdominal discomfort
3
thinning
3
autodigestion
3
dizziness
3
night sweats
3
spasm
3
shortness of breath
3
cyanosis
3
Lower urinary tract symptoms
3
pelvic pain
3
ketonuria
3
tremor
3
regurgitation
3
asthenia
3
hyperoxia
2
nausea and vomiting
2
exertional angina
2
female puberty
2
more...
Drug
Cardiovasc
375
Dermatol
171
Fructose
128
niacin
111
vitamin E
106
ROS
74
ascorbate
59
ADM
48
lysine
44
ROC
44
caffeine
39
EPA
37
Bifidobacterium
35
Rimonabant
32
Monit
28
Glucagon
23
Angiotensin II
23
Growth hormone
22
Growth hormone
21
Leaf
19
NADH
19
Rosiglitazone
19
Ezetimibe
19
ALA
19
Simvastatin
18
Rosuvastatin
18
MAP
16
IL-2
15
Vitamin A
15
Bezafibrate
15
Orlistat
14
Estrogens
14
Vitamin E
13
ABC
13
Spectrum
12
Asthma
11
citric acid
11
Nitric Oxide
11
Dial
10
Kenyan
10
Olmesartan
10
nitroglycerin
10
Check
10
Valsartan
9
Albumin
9
CSF
9
Glutathione
8
Nebivolol
8
Heme
8
Olive oil
8
EE2
8
lactose
7
HCH
7
PTH
7
Nephron
7
BH4
7
Portal
6
VCR
6
Aloe
6
Pravastatin
6
p75
6
Captopril
6
Aliskiren
5
Ethanol
5
Glycyrrhiza
5
Febuxostat
5
Troglitazone
5
Lovastatin
5
Ramipril
5
Ginseng
5
NAH
5
AHF
5
Wine
5
CCL
5
IFN-gamma
4
Android
4
Indomethacin
4
DM1
4
TAK
4
Creosote
4
more...
Enzyme
renin
346
alanine aminotransferase
315
AMP-activated protein kinase
306
mitogen-activated protein kinase
223
aspartate aminotransferase
178
superoxide dismutase
165
ACE
141
protein kinase
140
AMPK
123
AMPK
123
catalase
107
ERK
106
lipoprotein lipase
98
NADPH oxidase
92
11beta-hydroxysteroid dehydrogenase
86
gamma-glutamyl transpeptidase
78
NADPH oxidase
78
AST
73
lipase
70
acetyl-CoA carboxylase
58
focal adhesion kinase
58
NO synthase
55
glutathione peroxidase
53
luciferase
51
xanthine oxidase
48
peroxidase
44
protein kinase C
42
alkaline phosphatase
41
phosphoenolpyruvate carboxykinase
41
phosphodiesterase
40
phospholipase A2
39
LPL
37
ATPase
33
calcineurin
32
phosphatidylinositol 3-kinase
30
CPT
30
phosphoenolpyruvate carboxykinase
29
phosphoenolpyruvate carboxykinase
29
tissue plasminogen activator
28
creatine kinase
28
prostate-specific antigen
27
glucokinase
27
hormone-sensitive lipase
26
HSD
24
thrombin
24
alpha-glucosidase
23
paraoxonase
23
caspase-1
23
paraoxonase
22
glucose-6-phosphatase
22
reverse transcriptase
22
CAD
21
CAD
21
CAD
21
heme oxygenase
21
aldehyde dehydrogenase
20
ACS
20
proteasome
20
soluble epoxide hydrolase
19
3-hydroxy-3-methylglutaryl coenzyme A reductase
19
glutathione reductase
19
caspase-3
18
CYP7A1
18
NOS
17
lactate dehydrogenase
17
methylenetetrahydrofolate reductase
17
methylenetetrahydrofolate reductase
17
fructokinase
16
GSK
16
acetylcholinesterase
15
phosphoinositide 3-kinase
15
ketohexokinase
15
glucose-6-phosphate dehydrogenase
15
CPT
14
CPT
14
MAP
14
IKK
14
cholinesterase
14
complex I
13
guanylate cyclase
13
more...
Compound
glucose
6076
Clin
2057
Dec
1648
Insulin
1047
Cholesterol
745
oxygen
629
Cardiol
563
ATP
554
water
508
DNA
457
calcium
396
TNF
369
nitric oxide
363
creatinine
277
vitamin D
274
sodium
269
aldosterone
243
salt
171
acetate
153
phosphate
144
iron
141
silver
139
homocysteine
132
Fructose
128
ethanol
123
Diabetol
115
Metformin
112
Metformin
112
Diabetol
112
arginine
105
potassium
104
Testosterone
99
Pac
99
Testosterone
98
methionine
96
nitrogen
95
DBP
87
PMA
87
DBP
87
tyrosine
85
hydrogen
84
zinc
83
urea
82
AMP
79
Vitamin D
78
serine
75
nicotinic acid
73
palmitic acid
68
Uric acid
67
CoA
61
alanine
60
NAD
60
palmitic acid
59
glycerol
57
GSH
57
GSH
57
glutamate
56
nicotinic acid
56
nicotinic acid
55
nicotinic acid
55
cAMP
54
AHA
54
DHA
52
leucine
52
lysine
51
retinol
51
nitrate
50
Angiotensin II
50
copper
50
NADPH
47
NADPH
47
selenium
47
Androgen
46
Resveratrol
45
NAD
45
cysteine
45
sulfate
45
threonine
44
nicotinamide
42
Melatonin
40
more...