Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0948265 (metabolic syndrome)
 24,271 document(s) hit in 31,850,051 MEDLINE articles (0.02 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
insulin 8992
HDL 1727
Sep 1403
adiponectin 1208
leptin 1120
Mol 991
C-reactive protein 811
gut 723
ATP 554
cytokine 414
tumor necrosis factor 373
TNF 369
renin 346
adipokine 318
IL-6 306
peroxisome proliferator-activated receptor 304
hemoglobin 286
Adiponectin 261
peroxisome proliferator-activated receptor gamma 250
CRP 232
interleukin-6 225
albumin 216
AMP-activated protein kinase 200
endoplasmic reticulum 199
glucagon 191
insulin receptor 181
resistin 177
alanine aminotransferase 177
angiotensin II 177
fibrinogen 174
HSD1 170
Leptin 166
plasminogen activator inhibitor-1 163
PPAR 162
apolipoprotein B 157
collagen 144
superoxide dismutase 140
ghrelin 137
epididymal 136
IRS-1 131
Men 128
apolipoprotein 126
nuclear receptor 124
AMPK 123
SBP 114
aspartate aminotransferase 109
lipopolysaccharide 105
glucocorticoid receptor 104
ACE 98
mTOR 98
lipoprotein lipase 98
catalase 95
nitric oxide synthase 95
TNF-alpha 95
glucose transporter 94
insulin-like growth factor 90
growth hormone 88
DBP 86
angiotensin receptor 86
visfatin 84
sex hormone-binding globulin 83
fatty acid synthase 82
histone 78
IL-10 78
TLR4 77
MCP-1 77
PI3K 76
MAPK 75
ROS 74
ferritin 73
JNK 72
AKT 72
AST 72
mineralocorticoid receptor 72
reductase 71
leptin receptor 70
GLUT4 67
AMP 66
chemerin 65
CD36 65
endothelial nitric oxide synthase 65
PGC 65
plasminogen activator inhibitor 64
farnesoid X receptor 63
p38 63
IGF-1 62
interleukin 6 60
Peroxisome proliferator-activated receptor 60
interferon 59
Ang II 59
ANOVA 59
Pol 59
calcium channel 59
uncoupling protein 1 59
vascular endothelium 58
monocyte chemoattractant protein-1 57
apolipoprotein E 57
LDL receptor 56
acetyl-CoA carboxylase 55
brain-derived neurotrophic factor 55
GSH 54
eNOS 54
tumor necrosis factor alpha 54
glycoprotein 53
inducible nitric oxide synthase 53
prolactin 53
IL-1 52
glutathione peroxidase 52
lipase 52
IL-8 52
endothelin-1 51
NMR 50
neuropeptide Y 50
vascular endothelial growth factor 49
angiotensin II receptor 49
CHD 48
SIRT1 48
glucosidase 48
DM2 48
Cytokine 48
apoE 47
NADPH 47
LPS 47
thyroid hormone 46
MRI 46
chemokine 46
EPA 45
SREBP-1c 45
vascular cell adhesion molecule-1 45
NAD 45
protein kinase B 44
HMG-CoA reductase 43
peptidase 43
CB1 43
cytochrome P450 43
HSD2 42
Ghrelin 42
GLP-1 42
xanthine oxidase 42
beta-endorphin 42
estrogen receptor 41
Fibroblast growth factor 21 41
amylase 41
alkaline phosphatase 41
ERK 40
phosphodiesterase 40
ACTH 40
ERK1 39
IFN 39
STAT3 39
Nrf2 39
stearoyl-CoA desaturase 38
3 beta-HSD 38
microsomal 38
IL-17 37
LPL 37
SREBP-1 37
heme oxygenase-1 37
aP2 37
androgen receptor 37
more...
Disease
metabolic syndrome 24271
obesity 10003
diabetes 7253
hypertension 5145
type 2 diabetes 4303
cardiovascular disease 3997
dyslipidemia 2742
atherosclerosis 1832
fatty liver 1592
cancer 1361
glucose intolerance 1172
hyperglycemia 1131
abdominal obesity 1100
Nonalcoholic fatty liver 898
hyperlipidemia 831
hyperinsulinemia 782
cirrhosis 723
stroke 665
coronary heart disease 661
coronary artery disease 608
liver disease 605
alcoholic fatty liver 529
hepatocellular carcinoma 523
polycystic ovary syndrome 431
depression 426
heart failure 394
hypercholesterolemia 371
myocardial infarction 368
renal disease 368
hyperuricemia 343
schizophrenia 340
chronic liver disease 329
psoriasis 295
tumor 282
osteoporosis 274
obstructive sleep apnea 256
Alzheimer's disease 251
HIV 234
plaque 231
heart disease 218
vascular disease 209
prediabetes 206
hypogonadism 203
metabolic disorder 198
myocardial ischemia 197
chronic disease 189
ischemia 185
prostate cancer 184
microalbuminuria 184
cognitive impairment 184
breast cancer 183
gestational diabetes mellitus 176
gout 172
malnutrition 172
erectile dysfunction 168
liver fibrosis 163
type 1 diabetes 157
essential hypertension 153
dementia 152
hepatitis C 151
lipodystrophy 143
sleep apnea 142
atherosclerotic cardiovascular disease 138
hyperandrogenism 136
Syndrome 134
rheumatoid arthritis 129
infertility 129
cardiovascular risk factor 125
hyperphagia 123
arthritis 122
renal failure 121
proteinuria 119
inflammatory bowel disease 119
vitamin D deficiency 118
diabetic nephropathy 115
osteoarthritis 115
overnutrition 114
mental illness 108
carcinogenesis 107
colorectal cancer 100
ventricular hypertrophy 100
chronic obstructive pulmonary disease 99
Cushing's syndrome 99
syndrome X 98
preeclampsia 98
asthma 98
congestive heart failure 96
AIDS 93
liver cancer 88
psychosis 87
infectious diseases 87
skin disease 87
psoriatic arthritis 86
chronic hepatitis 85
bipolar disorder 85
hypothyroidism 82
morbid obesity 82
hepatitis B 81
hypoglycemia 79
acute myocardial infarction 79
cardiomyopathy 78
sexual dysfunction 76
sleep disorders 75
carcinoma 74
arteriosclerosis 72
neuropathy 72
anemia 70
Best 69
hepatitis 69
chronic renal failure 68
retinopathy 66
liver cancer 65
Endothelial dysfunction 63
cold 62
gallstones 62
systemic lupus erythematosus 61
endocrine disorder 60
periodontitis 59
tumorigenesis 58
immunodeficiency 58
West 57
hypercortisolism 56
nephrolithiasis 56
iron overload 56
glomerulosclerosis 56
anovulation 54
GSH 54
systemic disease 54
major depressive disorder 53
virus infection 52
viral hepatitis 52
endometrial cancer 51
Hepatocellular carcinoma 50
alcohol abuse 49
DM2 48
Parkinson's disease 47
hyperhomocysteinemia 47
renal impairment 46
acanthosis nigricans 46
aldosteronism 45
periodontal disease 45
acne 45
Brown 44
lipoatrophy 43
pancreatitis 43
Crohn's disease 43
psychological stress 43
Overweight and obesity 43
adenoma 42
autoimmune disease 41
peripheral vascular disease 41
aggression 40
diabetic retinopathy 39
myopathy 39
colon cancer 39
tumor growth 38
sepsis 37
sleep disturbances 37
alcoholism 36
FAS 36
more...
Symptom
overweight 1237
pain 133
fatigue 97
cachexia 69
angina 57
starvation 52
sleepiness 48
hunger 36
hepatomegaly 36
weakness 32
anorexia 27
insomnia 26
diarrhea 26
seizures 25
exhaustion 25
snoring 23
anesthesia 21
constipation 18
headache 16
respiratory distress 16
hot flashes 14
Depressive symptoms 13
collapse 13
menopausal symptoms 13
nausea 12
vomiting 12
polydipsia 10
chest pain 10
flushing 10
hypothermia 9
discomfort 9
discomfort 9
hypercapnia 9
masculinization 9
acute stress 9
memory loss 8
myalgia 8
dyspnea 8
polyuria 8
hypotonia 7
acidity 7
vertigo 6
abdominal pain 6
hot flushes 6
dystonia 6
arthralgia 5
cough 5
functional recovery 5
lethargy 5
erythema 4
tinnitus 4
back pain 4
peri-menopausal 4
enuresis 4
eds 4
hepatosplenomegaly 4
apathy 4
splenomegaly 4
hypersomnia 4
Catch 4
ataxia 3
thinning 3
pelvic pain 3
knee pain 3
night sweats 3
Lower urinary tract symptoms 3
spasm 3
cyanosis 3
dizziness 3
shortness of breath 3
autodigestion 3
abdominal discomfort 3
ketonuria 3
tremor 3
regurgitation 3
asthenia 3
nausea and vomiting 2
exertional angina 2
Ill 2
microbial colonization 2
Sedation 2
colic 2
stigma 2
physical appearance 2
numbness 2
myoclonus 2
alexithymia 2
Decreased activity 2
chronic constipation 2
syncope 2
hyperoxia 2
decreased appetite 2
leg cramps 2
bloating 2
paresthesia 2
dental pain 2
low back pain 2
female puberty 2
HSA 2
analgesia 2
SYMPTOMS 1
pachyonychia 1
loss of equilibrium 1
dry eye 1
hemoptysis 1
hip pain 1
cancer pain 1
Severe pain 1
personality change 1
asynergy 1
bone pain 1
shoulder pain 1
Cushingoid 1
urinary frequency 1
Musculoskeletal discomfort 1
Tissue sensitivity 1
dry skin 1
ACHE 1
spasticity 1
voice change 1
Scratch 1
chills 1
leg pain 1
unable to sleep 1
Appetite suppression 1
consciousness disturbance 1
Male sexual dysfunction 1
agitation 1
Welt 1
CSR 1
rigors 1
No adverse effect 1
tense 1
hand pain 1
lassitude 1
limb pain 1
Poor sleep 1
Murphy's sign 1
Exercise intolerance 1
corpulence 1
atypical chest pain 1
Metabolic symptoms 1
abnormal breathing 1
male subfertility 1
pallor 1
Stiffness 1
dysarthria 1
wheezing 1
anosmia 1
despair 1
nasal congestion 1
oliguria 1
paresis 1
Cushingoid 1
nocturnal polyuria 1
dysuria 1
bitter taste 1
ophthalmoplegia 1
male puberty 1
right upper quadrant pain 1
more...
Drug
Cardiovasc 375
Dermatol 171
Fructose 128
niacin 111
vitamin E 106
ROS 74
ascorbate 59
ADM 48
lysine 44
ROC 44
caffeine 39
EPA 37
Bifidobacterium 35
Rimonabant 32
Monit 28
Glucagon 23
Angiotensin II 23
Growth hormone 22
Growth hormone 21
ALA 19
NADH 19
Ezetimibe 19
Leaf 19
Rosiglitazone 19
Rosuvastatin 18
Simvastatin 18
MAP 16
Vitamin A 15
Bezafibrate 15
IL-2 15
Orlistat 14
Estrogens 14
ABC 13
Vitamin E 13
Spectrum 12
citric acid 11
Asthma 11
Nitric Oxide 11
nitroglycerin 10
Dial 10
Kenyan 10
Olmesartan 10
Check 10
Valsartan 9
Albumin 9
CSF 9
Nebivolol 8
Glutathione 8
EE2 8
Heme 8
Olive oil 8
HCH 7
lactose 7
PTH 7
Nephron 7
BH4 7
Portal 6
Pravastatin 6
VCR 6
p75 6
Aloe 6
Captopril 6
Ethanol 5
Febuxostat 5
Troglitazone 5
Wine 5
NAH 5
Ramipril 5
Lovastatin 5
Ginseng 5
AHF 5
Aliskiren 5
Glycyrrhiza 5
CCL 5
Ramelteon 4
Creosote 4
Indomethacin 4
Alanine 4
Tacrolimus 4
DHT 4
DHT 4
Nephron 4
Monosodium glutamate 4
THF 4
IFN-gamma 4
Android 4
DM1 4
TAK 4
CAM 4
Capsicum 4
Epigallocatechin 3
TAC 3
ACT 3
DEX 3
ENT 3
Activin 3
Infliximab 3
GHRP 3
Triclosan 3
IL-1ra 3
Gemfibrozil 3
DPA 3
Acacia 3
Tibolone 3
Infliximab 3
Luteinizing 3
Frontal 3
Honey 2
Asn 2
CTX 2
CTX 2
Colesevelam 2
Bosentan 2
Everolimus 2
L-tyrosine 2
PFA 2
Ginger 2
MgSO4 2
Actos 2
Micardis 2
Serum albumin 2
Adenosine deaminase 2
pyridoxal phosphate 2
Avandia 2
Red ginseng 2
Glycerol 2
CIA 2
Bosentan 2
Exenatide 2
linolenate 2
Retinoic acid 2
Diurnal 2
EPI 2
OTC 2
Phosphatidylserine 2
Dihydrotestosterone 2
Phentolamine 2
CTX 2
Adalimumab 2
Prednisone 2
Radicut 2
Histamine 2
Cynt 2
Atenolol 2
Gel 2
Spectrum 2
Hydrochlorothiazide 2
Mutagen 2
PCB 2
TAT 2
NOV 2
Prednisolone 2
OTC 2
Omacor 2
Areca 2
Adenosine triphosphate 2
Tesaglitazar 1
Perindopril 1
Digitalis 1
Adriamycin 1
more...
Enzyme
renin 346
alanine aminotransferase 315
AMP-activated protein kinase 306
mitogen-activated protein kinase 223
aspartate aminotransferase 178
superoxide dismutase 165
ACE 141
protein kinase 140
AMPK 123
AMPK 123
catalase 107
ERK 106
lipoprotein lipase 98
NADPH oxidase 92
11beta-hydroxysteroid dehydrogenase 86
gamma-glutamyl transpeptidase 78
NADPH oxidase 78
AST 73
lipase 70
acetyl-CoA carboxylase 58
focal adhesion kinase 58
NO synthase 55
glutathione peroxidase 53
luciferase 51
xanthine oxidase 48
peroxidase 44
protein kinase C 42
phosphoenolpyruvate carboxykinase 41
alkaline phosphatase 41
phosphodiesterase 40
phospholipase A2 39
LPL 37
ATPase 33
calcineurin 32
CPT 30
phosphatidylinositol 3-kinase 30
phosphoenolpyruvate carboxykinase 29
phosphoenolpyruvate carboxykinase 29
tissue plasminogen activator 28
creatine kinase 28
glucokinase 27
prostate-specific antigen 27
hormone-sensitive lipase 26
thrombin 24
HSD 24
caspase-1 23
paraoxonase 23
alpha-glucosidase 23
glucose-6-phosphatase 22
reverse transcriptase 22
paraoxonase 22
CAD 21
CAD 21
CAD 21
heme oxygenase 21
proteasome 20
aldehyde dehydrogenase 20
ACS 20
soluble epoxide hydrolase 19
3-hydroxy-3-methylglutaryl coenzyme A reductase 19
glutathione reductase 19
CYP7A1 18
caspase-3 18
methylenetetrahydrofolate reductase 17
lactate dehydrogenase 17
methylenetetrahydrofolate reductase 17
NOS 17
GSK 16
fructokinase 16
phosphoinositide 3-kinase 15
ketohexokinase 15
glucose-6-phosphate dehydrogenase 15
acetylcholinesterase 15
CPT 14
CPT 14
MAP 14
cholinesterase 14
IKK 14
uricase 13
guanylate cyclase 13
complex I 13
PDK1 12
succinate dehydrogenase 12
AMP-activated kinase 12
angiotensin-converting enzyme 2 11
arginase 11
BAT 11
xanthine dehydrogenase 11
CaMKII 10
diacylglycerol acyltransferase 10
pyruvate dehydrogenase 10
collagenase 10
ceruloplasmin 10
lipoxygenase 10
aldose reductase 9
cholesterol acyltransferase 9
CD10 9
APC 9
MEK 9
NQO1 9
glutathione S-transferase 8
trypsin 8
citrate synthase 8
CYP3A4 8
glyceraldehyde-3-phosphate dehydrogenase 8
ATP synthase 8
furin 8
acyl-CoA dehydrogenase 7
PARP 7
urokinase-type plasminogen activator 7
subtilisin 7
demethylase 7
kallikrein 7
aldehyde dehydrogenase 6
pyruvate kinase 6
pyruvate dehydrogenase 6
glyceraldehyde-3-phosphate dehydrogenase 6
pyruvate dehydrogenase 6
proprotein convertase 6
AOR 6
dipeptidyl peptidase IV 6
glucose oxidase 6
aldehyde dehydrogenase 6
RNA polymerase 6
cytochrome oxidase 6
21-hydroxylase 6
acyl-CoA oxidase 6
3-hydroxy-3-methylglutaryl-CoA reductase 6
plasmin 6
isocitrate dehydrogenase 6
isocitrate dehydrogenase 6
pepsin 6
histone acetyltransferase 6
aldehyde dehydrogenase 6
aldehyde dehydrogenase 6
PKG 5
glyceraldehyde-3-phosphate dehydrogenase 5
alpha-amylase 5
bile salt hydrolase 5
glycerol kinase 5
fatty acid desaturase 5
glyceraldehyde-3-phosphate dehydrogenase 5
aldolase 5
carnitine acetyltransferase 5
phosphofructokinase 5
factor C 5
20beta-hydroxysteroid dehydrogenase 5
AGT 5
dimethylarginine dimethylaminohydrolase 5
TOR 5
MMP 5
phosphorylase 5
glyceraldehyde-3-phosphate dehydrogenase 5
MIP 5
acyl-CoA synthetase 5
indoleamine 2,3-dioxygenase 4
lysyl oxidase 4
thromboplastin 4
lactase 4
glycerol-3-phosphate dehydrogenase 4
more...
Compound
glucose 6076
Clin 2057
Dec 1648
Insulin 1047
Cholesterol 745
oxygen 629
Cardiol 563
ATP 554
water 508
DNA 457
calcium 396
TNF 369
nitric oxide 363
creatinine 277
vitamin D 274
sodium 269
aldosterone 243
salt 171
acetate 153
phosphate 144
iron 141
silver 139
homocysteine 132
Fructose 128
ethanol 123
Diabetol 115
Diabetol 112
Metformin 112
Metformin 112
arginine 105
potassium 104
Pac 99
Testosterone 99
Testosterone 98
methionine 96
nitrogen 95
PMA 87
DBP 87
DBP 87
tyrosine 85
hydrogen 84
zinc 83
urea 82
AMP 79
Vitamin D 78
serine 75
nicotinic acid 73
palmitic acid 68
Uric acid 67
CoA 61
NAD 60
alanine 60
palmitic acid 59
glycerol 57
GSH 57
GSH 57
glutamate 56
nicotinic acid 56
nicotinic acid 55
nicotinic acid 55
AHA 54
cAMP 54
leucine 52
DHA 52
lysine 51
retinol 51
nitrate 50
Angiotensin II 50
copper 50
NADPH 47
selenium 47
NADPH 47
Androgen 46
NAD 45
sulfate 45
Resveratrol 45
cysteine 45
threonine 44
nicotinamide 42
Melatonin 40
caffeine 39
Pioglitazone 39
Statin 38
DHA 38
tryptophan 38
EPA 37
DHA 37
Fenofibrate 37
Ang II 36
His 35
ADP 35
tryptophan 35
cGMP 35
tryptophan 34
galactose 34
noradrenaline 34
tryptophan 34
ACTH 32
CO2 31
ADP 31
Cortisol 31
Optimal 30
Mg2+ 30
Thyroid 30
chromium 30
DSM 30
TSH 29
ADP 29
Estrogen 29
FFA 28
retinoic acid 28
prostacyclin 27
DPP 27
acetyl-CoA 27
Estrogen 27
iodine 25
BMC 25
Atorvastatin 25
Telmisartan 24
MDA 23
phosphorus 23
Glucagon 23
betaine 23
Oil Red O 22
Clozapine 22
Oil Red O 21
H2O2 21
oxalate 21
Salt 21
Sodium 20
proline 20
adenylate 20
ACh 20
Sucrose 20
ACS 20
Ile 20
ACS 20
Curcumin 19
glutamine 19
ASA 19
gallic acid 19
NADH 19
adenosylmethionine 18
8-OHdG 18
NADP 18
N-acetylcysteine 18
acetic acid 18
THP 18
L-carnitine 18
Adrenal 17
malonyl-CoA 16
isoleucine 16
isoleucine 16
Gly 16
cadmium 16
MAP 15
Olanzapine 15
THP 15
SDS 15
Bisphenol A 15
more...