UMLS:C0948265 - FACTA Search

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Query: UMLS:C0948265 (metabolic syndrome)
24,271 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A growing body of evidence suggests that the metabolic syndrome and hostility are independent risk factors for the development of coronary heart disease. However, few studies have examined the combined effect of the metabolic syndrome and hostility on the incidence of myocardial infarction (MI). We examined prospectively the relation among the metabolic syndrome, hostility, and the incidence of MI in healthy, older men (mean +/- SD 59.7 +/- 7.2 years) who participated in the Normative Aging Study. Seven hundred fifty-four men who were diagnosed as not having coronary heart disease and diabetes mellitus were included in the present study. Men were assigned to 1 of 4 risk-factor groups based on the presence or absence of the metabolic syndrome and low or high hostility. Hierarchical logistic regression was used to assess the multivariate risk of developing a MI. The incidence of MI was 11.3% (n = 85) over an average follow-up period of 13.8 years. After adjusting for potential covariates, risk-factor group significantly predicted the incidence of MI (odds ratio 1.59, 95% confidence interval 1.29 to 1.96, p <0.0001). The effect was strongest among patients who had the metabolic syndrome and high levels of hostility, with this subgroup showing a fourfold increase in the odds of developing a MI (odds ratio 4.21, 95% confidence interval 2.21 to 8.04, p = 0.0001). In conclusion, it appears that hostility may provide additional prognostic information to the assessment of coronary heart disease risk in patients with the metabolic syndrome and should routinely be evaluated as part of a comprehensive risk factor assessment.
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PMID:Combined effect of the metabolic syndrome and hostility on the incidence of myocardial infarction (the Normative Aging Study). 1631 Apr 55

We assessed the distribution of several risk factors related to health: muscular strength (handgrip strength), cardiovascular endurance (step test), flexibility (sit and reach test), anthropometry and body composition, blood pressure, fasting plasma glucose, lipid profile, and hemoglobin in a cohort of Guatemalan adults who were born in four rural villages between 1962 and 1977. By 2002 approximately 32% had migrated to Guatemala City or elsewhere in the country. Men are more physically fit and leaner than women. Fatness, poor physical fitness, and metabolic syndrome are highly prevalent in women living in both rural and urban areas. Risk profiles worsen with increasing age. Men who migrated to Guatemala City have lower physical fitness, greater fatness and systolic blood pressure, and worse lipid profile than men who still live in their original villages. Such a pattern was not evident in women, except that blood pressure was higher in urban women than in women who lived in their original villages.
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PMID:Physical fitness, body composition, blood pressure, and blood metabolic profile among young Guatemalan adults. 1606 Feb 15

Men with the metabolic syndrome demonstrate an increased prevalence of erectile dysfunction (ED). In the present study, we tested the effect of a Mediterranean-style diet on ED in men with the metabolic syndrome. Men were identified in our database of subjects participating in controlled trials evaluating the effect of lifestyle changes and were included if they had a diagnosis of ED associated with a diagnosis of metabolic syndrome, complete follow-up in the study trial, and intervention focused mainly on dietary changes. Sixty-five men with the metabolic syndrome met the inclusion/exclusion criteria; 35 out of them were assigned to the Mediterranean-style diet and 30 to the control diet. After 2 years, men on the Mediterranean diet consumed more fruits, vegetables, nuts, whole grain, and olive oil as compared with men on the control diet. Endothelial function score and inflammatory markers (C-reactive protein) improved in the intervention group, but remained stable in the control group. There were 13 men in the intervention group and two in the control group (P=0.015) that reported an IIEF score of 22 or higher. Mediterranean-style diet rich in whole grain, fruits, vegetables, legumes, walnut, and olive oil might be effective per se in reducing the prevalence of ED in men with the metabolic syndrome.
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PMID:Mediterranean diet improves erectile function in subjects with the metabolic syndrome. 1639 20

Several cardiovascular risk factors have been linked to antipsychotic treatment and cardiovascular mortality is increased in these patients compared to the general population. The full metabolic syndrome (or its components) is associated with an increased risk of cardiovascular disorders. The prevalence of the metabolic syndrome was investigated using a cross-sectional study design in a cohort of 269 patients, aged 20-69 years, with schizophrenia living in Northern Sweden, and was defined according to the criteria of the National Cholesterol Education program. The prevalence of the metabolic syndrome was 34.6% (95% CI = 28.8-40.3) and highest (43%; 95% CI = 32-53) for participants aged 40-49 years. Clozapine treated subjects reached the highest prevalence of the metabolic syndrome (48%; 95% CI = 34-62). The prevalence was similar for men (32.8%; 95% CI = 25.8-39.8) and women (38.0%; 95% CI = 27.9-48.2). Men had a high prevalence of hypertension (49.2%; 95% CI = 41.7-56.6) and women had high prevalence of low high-density lipoprotein cholesterol (40.2%; 95% CI = 30.0-50.4) and abdominal obesity (75.0%; 95% CI = 66.0-84.0). Subjects with the metabolic syndrome had significantly higher mean body mass index (BMI) (P < 0.001), HbA1c (P = 0.002), and fasting serum insulin (P < 0.001) compared to non-metabolic syndrome subject. Subjects with the metabolic syndrome had also significantly more often a positive history of cardiovascular diseases compared to non-metabolic syndrome subjects (25.8% versus 12.5%; P = 0.01). Of all study subjects 36.8% were obese (BMI > 30). These results clearly show that the metabolic syndrome and its components are highly prevalent in patients with schizophrenia. Physicians treating patients with schizophrenia are recommended to monitor the components included in the metabolic syndrome.
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PMID:High prevalence of the metabolic syndrome among a Swedish cohort of patients with schizophrenia. 1642 60

We investigated the prevalence of metabolic syndrome in patients with obstructive sleep apnea syndrome (OSAS) referred to a tertiary university-based medical center. A cross-sectional study of patients with a definite diagnosis of OSAS was performed using new diagnostic criteria for metabolic syndrome that were designed for the Japanese population. Clinical features and comorbidities related to metabolic syndrome were compared between 819 patients with OSAS (719 men and 100 women) and 89 control subjects without OSAS. Metabolic syndrome was significantly more common in the patients with OSAS than in the controls (49.5% vs. 22.0% for men, p < 0.01; 32.0% vs. 6.7% for women, p < 0.01). Men with OSAS (apnea-hypopnea index [AHI] > or =5/h) had a higher risk of metabolic syndrome compared with controls (odds ratio [OR]: 3.47; 95% confidence interval [CI]: 1.84-6.53). There was a significantly increased risk of metabolic syndrome in men with moderate OSAS (AHI: 15-29.9/h) (OR: 2.83; 95% CI: 1.42-5.66) and men with severe OSAS (AHI > or =30/h) (OR: 5.09; 95% CI: 2.67-9.71). Women with OSAS (AHI> or =5/h) also had an increased risk of metabolic syndrome (OR: 6.59; 95% CI: 1.47-29.38), and the risk was significantly higher in women with severe OSAS (AHI > or =30/h) (OR 14.00; 95% CI: 2.93-66.82). Risk factors for metabolic syndrome differed by gender: in men, age, body mass index (BMI), and OSAS (AHI > or =15/h) were significantly associated with metabolic syndrome, whereas, in women, BMI was the only risk factor for metabolic syndrome. The increase of metabolic syndrome in Japanese OSAS patients suggests that this patient population is burdened with multiple risk factors for cardiovascular disease.
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PMID:Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. 1683 51

The objective of this study is to examine the association between serum levels of insulin and homocysteine (Hcy) in a population-based sample of Swedish men and women. Men and women (537 and 571, respectively) 40 years or older, who were randomly selected from the population in Skara, southwestern Sweden, with valid information on serum levels of Hcy and insulin, were subject to a physical examination, including anthropometric measurement. Lifestyle factors were assessed by a questionnaire, and venous blood samples were drawn after an overnight fast. Insulin resistance was estimated by the homeostasis model assessment index. Homocysteine was higher in men (11.0 micromol/L) than in women (9.7 micromol/L) (P < .001) and was positively associated with age (P < .001 in both sexes) and serum creatinine (P = .009 in men, P < .001 in women), but inversely associated with leisure time physical activity (P = .012 in men, P = .001 in women). There was a positive association between serum insulin and serum Hcy independent of age and sex (P = .004). Upon exclusion of patients with diabetes and individuals with serum creatinine level greater than 130 microcat/L, this association was significant in the remaining 999 individuals also after adjustment for age, sex, serum creatinine, leisure time physical activity, body mass index, and smoking status (P = .003). A 1 SD difference in serum insulin corresponded to a difference of 0.5 micromol/L in serum Hcy. A similar association was found between insulin resistance and serum Hcy. In conclusion, there is an association between serum insulin and Hcy that may constitute a link between the metabolic syndrome and Hcy, either unilaterally or as part of a vicious circle.
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PMID:Associations between serum insulin and homocysteine in a Swedish population-a potential link between the metabolic syndrome and hyperhomocysteinemia: the Skaraborg project. 1683 34

To determine the prevalence of metabolic syndrome in the Japanese general population, we analyzed data from a nationwide survey conducted in 2000. According to the Japanese new diagnostic criteria for metabolic syndrome in 2005, we analyzed 3,264 people aged from 20 to 79 (men, 1,917; women, 1,347) from the total participants. The incidence of metabolic syndrome was 7.8%. Men had a higher incidence (12.1%) than women (1.7%). Most of the women satisfying the criteria were 50 years old or over, while the incidence in men started to rise from their 30s. When we applied the criteria of Adult Treatment Panel III, the incidence was about 3-fold higher. In this population visceral obesity was associated with metabolic abnormalities, such as higher LDL-cholesterol, triglyceride, glucose, and blood pressure and lower HDL-cholesterol. Thus we determined the incidence of metabolic syndrome and each metabolic abnormality in the Japanese general population in 2000 and found an association of visceral obesity with metabolic abnormalities. Intervention to reduce the incidence of metabolic syndrome in Japan is necessary to reduce the risk of cardiovascular disease.
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PMID:Prevalence of metabolic syndrome in the general Japanese population in 2000. 1690 53

The aim of the study was to establish whether metabolic syndrome predicts the incidence of prostate cancer. The hypothesis was tested using the 27-year follow-up of the prospective cohort of 16,209 men aged 40-49 years who participated in the Oslo Study in 1972-1973. Men with established diabetes and men with cancer diagnosed before screening were excluded, leaving 15,933 for analyses. Metabolic syndrome is here composed of body mass index, nonfasting glucose, triglycerides, and blood pressure or drug-treated hypertension. Two analytical approaches were compared, namely, predefined (adjusted from National Cholesterol Education Program) and quartile values of risk factors. Age, body mass index, and sedentary versus intermediate physical activity at work were significant predictors in univariate proportional hazards regression analyses. Combinations of any two (relative risk = 1.23; p = 0.04) or any three (relative risk = 1.56; p = 0.00) factors of the metabolic syndrome using quartile values of risk factors were predictive of prostate cancer. The number of cases for four factors was too small for analyses. Predefined values of the risk factors were not found to be predictive. In conclusion, metabolic syndrome was found to predict prostate cancer during 27 years of follow-up, indicating an association between insulin resistance and the incidence of prostate cancer.
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PMID:Metabolic syndrome predicts prostate cancer in a cohort of middle-aged Norwegian men followed for 27 years. 1695 29

The aim of the present study was to evaluate the relation among alcohol consumption, the metabolic syndrome, and the risk of ischemic heart disease (IHD). The study was conducted in a cohort of 1966 men from the Quebec Cardiovascular Study. All men were initially free of IHD and, during the follow-up period of 13 y, 219 first cases of IHD were diagnosed. Alcohol consumption was determined by calculating the g/d intake based on standard portions of beer, wine, and spirits. Metabolic syndrome was diagnosed according to a modification of the National Cholesterol Education Program Adult Treatment Panel III definition. Men who consumed >or=15.2 g of alcohol/d (4th quartile of the distribution) were younger (P < 0.001), had elevated plasma HDL-C concentrations (P < 0.001), and lower plasma concentrations of insulin (P = 0.01), CRP (P = 0.01), and fibrinogen (P < 0.001) than men in the 1st quartile (<1.3 g of alcohol/d). After adjustment for a series of coronary risk factors, alcohol consumption >or=15.2 g/d was associated with a 39% reduction in the 13-y risk of IHD [relative risk (RR) of IHD = 0.61, P = 0.02]. Finally, an alcohol consumption <15.2 g/d was associated with an increase of the risk of IHD in men with the metabolic syndrome (RR = 2.24, P < 0.001) but not in men without the metabolic syndrome (RR = 1.31, P = 0.22). These results confirm that moderate daily alcohol consumption has cardioprotective properties and suggest that the effects may be more important in subjects with a deteriorated risk profile, such as those with the metabolic syndrome.
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PMID:Moderate alcohol consumption is more cardioprotective in men with the metabolic syndrome. 1711 15

Sedentary behavior-related diseases can be prevented by lifestyle changes. Part of the cardiovascular benefits of physical activity (PA) may be due to low-grade inflammation. This study describes the PA of a population of Japanese and analyses its association with metabolic syndrome (MS) adjusted a number of variables. This was based on a database previously created following a population-based study of Japanese-Brazilians. 1,330 subjects aged > or = 30 years, of both sexes, living in Bauru, were included and they were submitted to interviews, being obtained sociodemographic, health, physical activity and dietary data, as well as clinical and laboratory data. Physical activity assessment focused on activities during work and leisure times. Diagnosis of MS was based on an adaptation of NCEP criteria for Asians. Non-conditional logistic regression had MS as the dependent variable. Men (46.1%) and women showed similar mean ages (57.0 +/- 12.8 and 56.9 +/- 12.2 years, respectively). A slight preponderance of females was observed. Men had a higher level of education and more frequently were smokers (p< 0.001); their mean values of BMI, waist and blood pressure (p< 0.001) were higher than the womens. For both sexes, the majority referred light and moderate activities (81.2% of men and 86.6% of women). As far as work time is concerned, 87.8% of men classified their effort as light or moderate versus 96.1% of women. Distribution by PA levels showed that women were always less active than men (p= 0.01). Stratifying by the presence of MS, men and women with MS were significantly older and showed greater anthropometric values. Considering the walking duration for work, there was a tendency of shorter periods among those with MS (p< 0.078). As expected, subjects with MS showed significantly higher levels of blood pressure, plasma glucose, lipids and HOMA-IR when compared to those without MS. HDL levels were lower in the MS group, being significant for the female sex. The mean values of CRP were higher in subjects with MS. In logistic regression, age, BMI, HOMA-IR and CRP were shown to be independently associated with MS, but not parameters used to measure physical activity. Our findings do not allow to state that physical inactivity is associated with MS in a Japanese-Brazilian population. High frequencies of physical inactivity should have contributed to the negative findings concerning protective effects of physical activity. The association of MS and serum CRP favors the hypothesis that a low-grade inflammatory state may participate in this syndrome.
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PMID:[Analysis on the association of physical activity with metabolic syndrome in a population-based study of Japanese-Brazilians]. 1722 Nov 13

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