Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0948265 (
metabolic syndrome
)
24,271
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In rodents a high-fructose diet induces metabolic derangements similar to those in
metabolic syndrome
. Previously we suggested that in mouse liver an unidentified nuclear protein binding to the sterol regulatory element (SRE)-binding protein-1c (SREBP-1c) promoter region plays a key role for the response to high-fructose diet. Here, using MALDI-TOF MASS technique, we identified an X-chromosome-linked RNA binding motif protein (
RBMX
) as a new candidate molecule. In electrophoretic mobility shift assay, anti-
RBMX
antibody displaced the bands induced by fructose-feeding. Overexpression or suppression of
RBMX
on rat hepatoma cells regulated the SREBP-1c promoter activity.
RBMX
may control SREBP-1c expression in mouse liver in response to high-fructose diet.
...
PMID:RBMX is a novel hepatic transcriptional regulator of SREBP-1c gene response to high-fructose diet. 1718 81
