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Query: UMLS:C0948265 (
metabolic syndrome
)
24,271
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oxidative stress is involved both in
metabolic syndrome
and male infertility. Hypogonadism is also associated with increased risk for cardiovascular disease. To investigate the role of gonadal steroids in systemic antioxidant regulation, we determined plasma CoenzymeQ(10) (
CoQ
(10)) and total antioxidant capacity (TAC) in postsurgical hypopituitaric patients. Twenty-six patients aged 28-55 years were studied 6-12 months after surgery.
CoQ
(10) levels were measured by high-performance liquid chromatography and TAC by spectroscopy with the use of the mioglobin-H(2)O(2) system, which, in interacting with chromogen 2,2(I)-azinobis-(3-ethylbenzothiazoline-6-sulfonate), generates a radical after a latency time (LAG) that is proportional to antioxidant content. Sixteen patients presented low testosterone values; in 10 patients hypogonadism was isolated, and in 6 patients hypothyroidism also was present.
CoQ
(10) levels were significantly lower in isolated hypogonadism than in normogonadism. Testosterone treatment, performed in those patients with isolated hypogonadism, induced a significant enhancement both in
CoQ
(10) level and LAG.
CoQ
(10) and LAG values correlated significantly, suggesting an interrelationship between different antioxidants. Our data suggest that hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk.
...
PMID:Effects of testosterone on antioxidant systems in male secondary hypogonadism. 1864 14
The aim of this study was to evaluate the effects of a high-fat diet (HFD) on oxidative indexes in WistarOttawaKarlsburg W (WOKW) rats used as a model of
metabolic syndrome
in comparison with Dark Agouti (DA) rats used as a control strain. This syndrome is defined by the occurrence of two or more risk factors including obesity, hypertension, dyslipidemia, and insulin resistance. Forty rats were used in the study and the effect of HFD was evaluated in terms of body weight and both hemoglobin and
CoQ
oxidative status. Moreover, 16 rats (8 of each strain) were supplemented with 3 mg/100 g b.w. of CoQ10 for 1 month in view of its beneficial properties in cardiovascular disease due to its antioxidant activity in the lipid environment. HFD promoted an increase in body weight, in particular in WOKW males, and in the methemoglobin (met-Hb) index in both strains. Moreover, HFD promoted endogenous CoQ10 oxidation. CoQ10 supplementation was able to efficiently counteract the HFD pro-oxidant effects, preventing met-Hb formation and
CoQ
oxidation.
...
PMID:High-fat diet-induced met-hemoglobin formation in rats prone (WOKW) or resistant (DA) to the metabolic syndrome: effect of CoQ10 supplementation. 2542 41
Coenzyme Q
(
CoQ
) is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory components of
CoQ
complex or in non-
CoQ
biosynthetic mitochondrial proteins can result in a decrease in
CoQ
concentration and/or an increase in oxidative stress. Besides
CoQ
10
deficiency syndrome and aging, there are chronic diseases in which lower levels of
CoQ
10
are detected in tissues and organs providing the hypothesis that
CoQ
10
supplementation could alleviate aging symptoms and/or retard the onset of these diseases. Here, we review the current knowledge of
CoQ
10
biosynthesis and primary
CoQ
10
deficiency syndrome, and have collected published results from clinical trials based on
CoQ
10
supplementation. There is evidence that supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics. Cardiovascular disease and inflammation are alleviated by the antioxidant effect of
CoQ
10
. There is a need for further studies and clinical trials involving a greater number of participants undergoing longer treatments in order to assess the benefits of
CoQ
10
treatment in
metabolic syndrome
and diabetes, neurodegenerative disorders, kidney diseases, and human fertility.
...
PMID:Coenzyme Q
10
Supplementation in Aging and Disease. 2945 30
Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q
10
(
CoQ
10
) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of
metabolic syndrome
. Here, prominent electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible RCTs reporting on any correlation between adipokine levels and modulation of inflammation and oxidative stress in individuals with
metabolic syndrome
taking
CoQ
10
. The risk of bias was assessed using the modified Black and Downs checklist, while the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to evaluate the quality of evidence. Results from the current meta-analysis, involving 318 participants, showed that
CoQ
10
supplementation in individuals with
metabolic syndrome
increased adiponectin levels when compared to those on placebo (SMD: 1.44 [95% CI: -0.13, 3.00];
I
2
= 96%,
p
< 0.00001). Moreover,
CoQ
10
supplementation significantly lowered inflammation markers in individuals with
metabolic syndrome
in comparison to those on placebo (SMD: -0.31 [95% CI: -0.54, -0.08];
I
2
= 51%,
p
= 0.07). Such benefits with
CoQ
10
supplementation were related to its ameliorative effects on lipid peroxidation by reducing malondialdehyde levels, concomitant to improving glucose control and liver function. The overall findings suggest that optimal regulation of adipokine function is crucial for the beneficial effects of
CoQ
10
in improving metabolic health.
...
PMID:Coenzyme Q
10
Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. 3237 40
Resveratrol (RSV) is a bioactive natural molecule that induces antioxidant activity and increases protection against oxidative damage. RSV could be used to mitigate damages associated to metabolic diseases and aging. Particularly, RSV regulates different aspects of mitochondrial metabolism. However, no information is available about the effects of RSV on
Coenzyme Q
(
CoQ
), a central component in the mitochondrial electron transport chain. Here, we report for the first time that RSV modulates
COQ
genes and parameters associated to
metabolic syndrome
in mice. Mice fed with high fat diet (HFD) presented a higher weight gain, triglycerides (TGs) and cholesterol levels while RSV reverted TGs to control level but not weight or cholesterol. HFD induced a decrease of
COQs
gene mRNA level, whereas RSV reversed this decrease in most of the
COQs
genes. However, RSV did not show effect on
CoQ
9
,
CoQ
10
and total
CoQ
levels, neither in
CoQ
-dependent antioxidant enzymes. HFD influenced mitochondrial dynamics and mitophagy markers. RSV modulated the levels of PINK1 and PARKIN and their ratio, indicating modulation of mitophagy. In summary, we report that RSV influences some of the metabolic adaptations of HFD affecting mitochondrial physiology while also regulates
COQs
gene expression levels in a process that can be associated with mitochondrial dynamics and turnover.
...
PMID:Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. 3242 95
