Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0948265 (metabolic syndrome)
 24,271 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We compared the prevalence and duration of action of common risk factors (RF) of arterial hypertension (AH), smoking, alcohol abuse, excess consumption of animal fats and carbohydrates, psychoemotional stress, inherited risk of coronary heart disease (CHD), AH, diabetes mellitus (DM), overweight/obesity, hypercholesterolemia (HC) and hypertriglyceridemia (HTG) contributing to combined cardiovascular pathology. In addition, RF of myocardial infarction (MI) were elucidated. The study involved 190 patients with CHD including 82 (43.2%) and 108 (56.8%) (mean age 53. 0 +/- 0.6 yr) suffering functional class I-III angina of effort (AE), metabolic syndrome and DM2. A combination of such RF as AH, HC, and HTG, psychoemotional stress, unhealthy diet, overweight/obesity DM2, smoking, and alcohol abuse were found to be associated with CHD and MI. Four RF were identified in 37.4 and 31.1% of the men and women respectively, 5 FR in 33.1 and 39.5%, 6 RF in 29.5 and 15.3%; 7 RF were revealed in 14.1% of the men. The history of IM was documented in 101 (53.2%) patients, Q-wave IM in 55 (28.9%), non-Q-wave MI in 46 (24.3%). Q-wave MI occurred in 142 and 14.7% of men and women respectively; non-Q-wave MI occurred 1.2 times more frequently in women than in men. It is concluded that early diagnosis of RF in young and middle-aged subjects may promote prevention or slow down progression of metabolic syndrome, AH, CHD, and DM2.
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PMID:[Timely estimation of risk factors of coronary heart disease as a basis of prevention of its complications]. 2351 47

The aim of the study was to evaluate results of combined therapy of stable 2-3 FC angina of effort with metabolic syndrome including metformin. Group 1 was comprised of 71 patients (38 (53.3%) men and 33 (46.5%) women), group 2 consisted of 57 patients treated with isosorbid-5 mononitrate (40 mg/d + amlodipin (5 mg/d) + eprosartan (600 mg/d) + thrombo ASS (100 mg/d) + carvedilol (25 mg/d) + atorvastatin (20 mg/d). Effects of the treatment were assessed 3, 6, and 12 months after its onset. At the end of the study, fasting blood glucose, total cholesterol, triglyceride, and low density lipoproteide levels decreased by 12.8, 10.9, 12.9 and 13.6% respectively compared with the initial values (p < 0.01). The level of high density lipoproteides increased by 10.4% (p < 0.01). Supplementation of therapy with metformin (1000 mg) decreased the frequency of episodes of painful and painless myocardial ischemia by 17.0 and 21.1%. Simultaneously, tolerance of physical load increased by 22.7%.
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PMID:[Results of combined therapy of stable 2-3 FC angina of effort with metabolic syndrome including metformin]. 2598 Feb 97