Gene/Protein
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Enzyme
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Pivot Concepts:
Gene/Protein
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Target Concepts:
Gene/Protein
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Query: UMLS:C0948265 (
metabolic syndrome
)
24,271
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Wnt signaling system plays essential roles in development, cancer and bone metabolism. Canonical wnt signaling, which involves wnt ligands, receptor named frizzled and co-receptors LRP5/6, beta-catenin and transcription factors named LEF/TCF is well characterized and its defect causes bone abnormalities. The loss-of-function type of the LRP5 gene mutation is responsible for
osteoporosis-pseudoglioma syndrome
. In addition, the LRP6 gene mutation leads to osteoporosis and
metabolic syndrome
. Thus, wnt signaling system is one of determinant factors for bone mineral density.
...
PMID:[Cytokines in bone diseases. Wnt signaling and osteoporosis-pseudoglioma syndrome]. 2089 34
