Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0920652 (
skin irritant
)
188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
2-Amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine (ACCPE) is a water soluble compound formed during the alkaline treatment of the alcoholic liquor in the production of 2-chlorobenzylidene
malononitrile
(CS). The acute toxicity and primary irritancy of ACCPE and CS were investigated and compared. Both perorally and intravenously, ACCPE was significantly less acutely toxic than CS. Also, whilst CS was a moderate dermal and eye irritant, ACCPE was not a primary
skin irritant
and only marginally irritating to the eye. ACCPE presents a significantly lower acute handling hazard than does CS.
...
PMID:Acute toxicity and primary irritancy of 2-amino-3,5-dicyano-4-o-chlorophenyl-6-ethoxypyridine. 393 60
