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Query: UMLS:C0920652 (skin irritant)
 188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The mouse ear irritant latex of E. virgata, has been found to contain various skin irritant and non-irritant esters of the diterpene ingenol. In cocarcinogenic assay on dorsal back skin of NMRI mice, acetone extract of this latex produces squamous cell papilloma. Using a combination of biologic and chemical separation techniques one of the initiator-promotor for skin carcinogenesis has been identified as 3-0-2 methyl-decanoyl ingenol.
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PMID:Tumor promoting and skin irritant diterpene esters of Euphorbia virgata latex. 645 73

Out of seven plants selected due to their use in folk medicine, five possessing ingenol as diterpene parent, exhibited mild skin irritancy where as E. striatella latex was highly skin irritant and produced papilloma, in initiation-promotion experiment on mouse back skin. This tumor promoting activity has been demonstrated due to the presence of ingenol-3-O-decanoate.
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PMID:Tumor promoting activity of Euphorbia striatella (Boiss) and skin irritant activity of some Euphorbia species. 673 58