Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0920646 (renal ischemia)
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Human Gene/Protein
ubiquitin-conjugating enzyme E2 variant 1 12.0
BLOC1S2 11.6
SPRR2F 11.6
MAPK organizer 1 11.3
RPH3A 11.0
fibronectin type III domain containing 3B 10.8
Tisp40 10.5
SIKE 10.2
IMMT 10.2
microtubule-associated proteins 1A/1B light chain 3 10.0
KCNRG 9.9
PRAT4A 9.8
70 kDa peroxisomal membrane protein 9.6
IGF2AS 9.6
hepatocyte growth factor-like 9.6
LOSK 9.6
ERBIN 9.5
UNC5D 9.5
DUBA 9.4
augmenter of liver regeneration 9.4
RAB21 9.3
NFAT5 protein 9.3
Meprin A 9.3
ROCK1 protein 9.2
ELG 9.2
FGFBP1 9.2
fzo 9.1
SLK 9.1
UNC5A 9.0
BCL-G 9.0
ATP6V1E1 9.0
SCIN 9.0
phospholipase A2-like 9.0
HSulf-1 9.0
COX8 8.9
channel-inducing factor 8.9
upregulated in kidney 8.9
tonicity-responsive enhancer binding protein 8.8
DOK2 8.8
DOK1 8.8
BCRP1 8.7
P2Y14 receptor 8.7
neutrophil gelatinase-associated lipocalin 8.7
HTK 8.6
ACAP1 8.6
IL-17RE 8.6
nucleotide-binding oligomerization domain containing 2 8.5
THW 8.5
serine threonine protein kinase 8.5
KIM-1 8.4
UNC5C 8.4
Angiopoietin-like 3 8.4
NRK 8.4
death receptor 6 8.4
CL-K1 8.4
Fibroblast growth factor 10 8.3
INOS 8.3
NGAL 8.3
FCN2 8.3
TOLLIP 8.2
APQ 8.2
C-X-C motif chemokine 5 8.2
PKN1 8.2
DAP5 8.2
PEG1 8.2
restin 8.2
RAR-related orphan receptor gamma 8.1
CSBP 8.1
NIMP 8.1
TIM-4 8.1
UT-A2 8.1
SLC22A8 8.1
Carnitine palmitoyltransferase I 8.0
Siva-1 7.9
WIPI2 7.9
PPP2R2B 7.9
FOXD1 7.9
IL-20R1 7.8
sphingomyelin phosphodiesterase 7.7
SOD2 protein 7.7
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Disease
renal ischemia 13.6
Acute renal failure due to ischemia 12.6
Renal artery dissection 10.8
Nephroangiosclerosis 10.5
renal artery obstruction 10.2
Renal cortical necrosis 10.2
Unilateral renal artery stenosis 9.9
Renal artery occlusion 9.8
Sickle cell nephropathy 9.8
tubular necrosis 9.6
high renin hypertension 9.5
Hyponatremic 9.3
Renovascular hypertension 8.8
renin-dependent hypertension 8.8
acute tubular necrosis 8.7
acute renal failure 8.3
canities 8.3
Scleroderma renal crisis 8.0
renal artery stenosis 7.9
Goldblatt 7.8
Oncocytoma 7.8
Oncocytoma 7.8
Oncocytoma 7.8
perinephritis 7.6
Systemic inflammatory response syndrome (SIRS) 7.5
Renal interstitial fibrosis 7.5
ischemia 7.3
Atherosclerotic renal artery stenosis 7.2
hypotension and shock 7.2
Azotemia 7.2
hypertensive cardiomyopathy 7.1
disorders of iron metabolism 7.0
Microangiopathy 7.0
Acute pyelonephritis 6.9
hypertensive nephropathy 6.9
Acute interstitial nephritis 6.9
azotemia 6.8
Mesenteric ischemia 6.8
hemoglobinemia 6.8
Angiodysplasia 6.8
nephrosclerosis 6.7
Glomerular diseases 6.7
malignant hypertension 6.7
Renal fibrosis 6.6
renal papillary necrosis 6.5
anuria 6.5
Interstitial fibrosis 6.5
laxative abuse 6.4
kidney infection 6.4
Ureteral obstruction 6.4
hyperargininemia 6.3
Spinal cord ischemia 6.2
secondary hypertension 6.2
renal hypertension 6.1
vascular obstruction 6.0
Goldblatt hypertension 6.0
kidney hypertrophy 5.9
Small intestine 5.9
Prinzmetal 5.9
renal failure 5.9
puerperal sepsis 5.7
HSP 5.7
hepatorenal syndrome 5.6
Fibromuscular dysplasia 5.6
secondary polycythemia 5.6
chronic renal insufficiency 5.6
urinary tract obstruction 5.6
hypoaldosteronism 5.6
renal insufficiency 5.4
polycystic kidney 5.4
kidney tumor 5.4
prostatic adenoma 5.4
hypermagnesemia 5.3
CYLD 5.3
Proteinuria 5.3
XPB 5.3
CHH 5.2
renal impairment 5.2
Vesicoureteral reflux 5.2
Severe sepsis 5.2
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Symptom
loin pain 7.3
disturbed balance 6.8
Crushing 6.7
oliguria 6.6
pedal edema 5.9
Anoxia 5.5
polyuria 5.4
flank pain 5.3
eye pain 5.1
excessive sweating 4.5
functional recovery 4.4
polydipsia 4.1
acute stress 3.8
hypothermia 3.6
hypoproteinemia 3.5
hyperoxia 2.9
spasm 2.8
thinning 2.8
pallor 2.3
tachypnea 2.3
paraparesis 2.2
HSA 2.1
anesthesia 2.0
memory loss 1.8
hypercapnia 1.7
shortness of breath 1.3
cachexia 1.2
lethargy 1.2
collapse 1.1
back pain 1.1
flushing 1.0
respiratory distress 1.0
vertigo 0.8
arthralgia 0.8
abdominal pain 0.7
starvation 0.6
dizziness 0.4
vomiting 0.3
nausea 0.1
weakness 0.0
anorexia -0.1
diarrhea -0.2
tremor -0.5
headache -0.6
discomfort -0.8
discomfort -0.9
fatigue -1.0
overweight -1.1
seizures -1.7
pain -1.8
Drug
Naloxone HCl 9.9
Cilastatin 8.2
Platelet Activating Factor 8.0
Fenoprofen 7.7
Cicletanine 7.2
Valproic Acid 7.1
Fenoldopam 7.1
Nexavar 6.9
Trapidil 6.8
Aliskiren 6.6
Febuxostat 6.5
Molsidomine 6.4
Nimesulide 6.4
Surgicel 6.4
Enalaprilat 6.4
Enalaprilat 6.4
3-Methyladenine 6.3
Iodixanol 6.2
Atipamezole 6.2
Iloprost 6.2
Ethane 5.9
Olmesartan 5.9
Phosphoramidon 5.9
Captopril 5.8
Ginger 5.7
Iopamidol 5.7
Clodronate 5.6
Nebivolol 5.6
NAG 5.6
Pregnenolone 5.5
Apixaban 5.5
Levosimendan 5.4
Copaxone 5.3
Sodium valproate 5.3
Artesunate 5.2
DMSA 5.1
Tao 5.1
Coral 5.0
CIA 5.0
Dextrose 5.0
Nephron 4.9
Aminoguanidine 4.9
beta-Galactosidase 4.9
Heme 4.8
Epigallocatechin 4.8
Maltose 4.8
EHDP 4.7
Reserpine 4.7
Iohexol 4.7
Neoral 4.6
Antithrombin III 4.6
Doxycycline 4.5
Misoprostol 4.5
IL-11 4.5
TES 4.5
Nephron 4.4
Urokinase 4.4
Lovastatin 4.3
Glutathione 4.2
Propofol 4.2
Rosiglitazone 4.0
Xanthium 3.9
Activin 3.9
Adenosine triphosphate 3.8
Gastro 3.8
ETA 3.8
ALA 3.8
Ringer's solution 3.7
Sodium nitroprusside 3.7
GRF 3.7
TAK 3.7
ROS 3.6
Clopidogrel 3.5
Infliximab 3.5
Infliximab 3.5
RFP 3.4
CoCl2 3.3
CoCl2 3.3
Indomethacin 3.3
Angiotensin II 3.3
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Enzyme
HK2 6.8
pantetheinase 6.8
3-mercaptopyruvate sulfurtransferase 6.7
peptidylarginine deiminase 6.7
carnosinase 6.7
serine racemase 6.4
SLB 6.4
NQO2 6.0
aminopeptidase P 5.9
NAD+ oxidoreductase 5.9
arginine deiminase 5.9
sphingosine kinase 5.7
C3b inactivator 5.6
cystathionine gamma-lyase 5.6
biliverdin reductase 5.5
xanthine oxidase 5.5
renin 5.4
caspase-11 5.2
caspase-11 5.2
E-2 5.2
gamma-glutamylcysteine synthetase 5.1
caspase-3 5.0
leucine aminopeptidase 5.0
xanthine dehydrogenase 4.9
PRA 4.9
heme oxygenase 4.9
TSP-1 4.9
PHD 4.9
CGT 4.8
MIP 4.8
superoxide dismutase 4.8
polyamine oxidase 4.8
TdT 4.7
O-GlcNAc transferase 4.7
SPT 4.6
meprin 4.5
thromboxane synthase 4.5
fumarase 4.5
glutathione peroxidase 4.4
caspase-1 4.3
neutral sphingomyelinase 4.2
CPM 4.2
monoacylglycerol lipase 4.2
mu-calpain 4.2
lactate dehydrogenase 4.2
cytochrome c peroxidase 4.2
alanine aminopeptidase 4.1
PAH 4.1
aldehyde oxidase 4.1
peroxidase 4.1
caspase-8 4.1
NADPH oxidase 4.0
AMP-activated protein kinase 4.0
caspase-9 3.9
catalase 3.9
paraoxonase 3.9
AST 3.9
aspartate aminotransferase 3.9
NADPH oxidase 3.9
NO synthase 3.9
caspase-7 3.8
ALDH 3.8
p100 3.8
SPT 3.8
prolyl hydroxylase 3.8
caspase-7 3.8
nitrite reductase 3.8
MEKK1 3.8
C3 convertase 3.8
MPP 3.8
nitrite reductase 3.7
nitrite reductase 3.7
cystathionine beta-synthase 3.7
DCF 3.7
kallikrein 3.6
nucleotidase 3.6
C3 convertase 3.6
farnesyltransferase 3.6
paraoxonase 3.6
AMPK 3.6
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Compound
LNO2 9.7
Gallein 9.5
Metipranolol 9.5
Gallein 9.5
Taraxasterol 9.3
Ethanethiol 8.9
Plastoquinone 8.6
Salvianolic acid A 8.5
Oxypurinol 8.4
C6H12O6 8.4
Cilastatin 8.2
Dioscin 8.1
Diaspirin 8.1
Dioscin 8.1
Fenoprofen 7.9
Diatrizoate 7.9
Notoginsenoside R1 7.9
Diatrizoate 7.9
Pimonidazole 7.8
Pimonidazole 7.8
Isoquercitrin 7.8
D-allose 7.8
DPPD 7.7
Carnosol 7.6
Polydatin 7.5
thieno[2,3-b]pyridine 7.5
Indoxyl sulfate 7.4
3-Nitrotyrosine 7.4
Dihydralazine 7.3
Caffeic acid phenethyl ester 7.3
Fenoldopam 7.2
creatinine 7.0
Sphingosine 1-phosphate 7.0
Aristolochic acid 6.9
Edaravone 6.9
3-Deazaneplanocin 6.9
NIX 6.9
dimethyl malonate 6.9
Triamterene 6.9
Paricalcitol 6.9
Ethyl pyruvate 6.8
Cerivastatin 6.8
Oltipraz 6.8
Zinc protoporphyrin 6.7
Inulin 6.6
Oxymatrine 6.6
S-allylcysteine 6.6
Pantoprazole 6.5
Cystathionine 6.5
Cystathionine 6.4
Glimepiride 6.4
SDMA 6.4
DCVC 6.4
Enalaprilat 6.4
IPC 6.4
TBHQ 6.4
Honokiol 6.3
Pioglitazone 6.3
ELA 6.3
DOA 6.3
ELA 6.3
Mannitol 6.3
3-Methyladenine 6.3
Hippuran 6.2
Mannitol 6.2
Mibefradil 6.2
Osthole 6.2
Sevoflurane 6.2
Nobiletin 6.1
Spironolactone 6.1
Pterostilbene 6.1
Mefenamic acid 6.1
Biliverdin 6.1
urea 6.0
Isoflurane 6.0
Fenofibrate 6.0
Magnolol 5.9
Phosphoramidon 5.9
IPC 5.9
Malondialdehyde 5.8
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