Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0920646 (renal ischemia)
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Human Gene/Protein
ubiquitin-conjugating enzyme E2 variant 1 12.0
BLOC1S2 11.6
SPRR2F 11.6
MAPK organizer 1 11.3
RPH3A 11.0
fibronectin type III domain containing 3B 10.8
Tisp40 10.5
IMMT 10.2
SIKE 10.2
microtubule-associated proteins 1A/1B light chain 3 10.0
KCNRG 9.9
PRAT4A 9.8
IGF2AS 9.6
70 kDa peroxisomal membrane protein 9.6
LOSK 9.6
hepatocyte growth factor-like 9.6
UNC5D 9.5
ERBIN 9.5
DUBA 9.4
augmenter of liver regeneration 9.4
RAB21 9.3
Meprin A 9.3
NFAT5 protein 9.3
ROCK1 protein 9.2
ELG 9.2
FGFBP1 9.2
fzo 9.1
SLK 9.1
BCL-G 9.0
UNC5A 9.0
SCIN 9.0
ATP6V1E1 9.0
HSulf-1 9.0
phospholipase A2-like 9.0
COX8 8.9
upregulated in kidney 8.9
channel-inducing factor 8.9
tonicity-responsive enhancer binding protein 8.8
DOK2 8.8
DOK1 8.8
more...
Disease
renal ischemia 13.6
Acute renal failure due to ischemia 12.6
Renal artery dissection 10.8
Nephroangiosclerosis 10.5
renal artery obstruction 10.2
Renal cortical necrosis 10.2
Unilateral renal artery stenosis 9.9
Renal artery occlusion 9.8
Sickle cell nephropathy 9.8
tubular necrosis 9.6
high renin hypertension 9.5
Hyponatremic 9.3
Renovascular hypertension 8.8
renin-dependent hypertension 8.8
acute tubular necrosis 8.7
acute renal failure 8.3
canities 8.3
Scleroderma renal crisis 8.0
renal artery stenosis 7.9
Goldblatt 7.8
Oncocytoma 7.8
Oncocytoma 7.8
Oncocytoma 7.8
perinephritis 7.6
Systemic inflammatory response syndrome (SIRS) 7.5
Renal interstitial fibrosis 7.5
ischemia 7.3
Atherosclerotic renal artery stenosis 7.2
hypotension and shock 7.2
Azotemia 7.2
hypertensive cardiomyopathy 7.1
disorders of iron metabolism 7.0
Microangiopathy 7.0
Acute pyelonephritis 6.9
hypertensive nephropathy 6.9
Acute interstitial nephritis 6.9
azotemia 6.8
Mesenteric ischemia 6.8
Angiodysplasia 6.8
hemoglobinemia 6.8
more...
Symptom
loin pain 7.3
disturbed balance 6.8
Crushing 6.7
oliguria 6.6
pedal edema 5.9
Anoxia 5.5
polyuria 5.4
flank pain 5.3
eye pain 5.1
excessive sweating 4.5
functional recovery 4.4
polydipsia 4.1
acute stress 3.8
hypothermia 3.6
hypoproteinemia 3.5
hyperoxia 2.9
spasm 2.8
thinning 2.8
pallor 2.3
tachypnea 2.3
paraparesis 2.2
HSA 2.1
anesthesia 2.0
memory loss 1.8
hypercapnia 1.7
shortness of breath 1.3
cachexia 1.2
lethargy 1.2
collapse 1.1
back pain 1.1
flushing 1.0
respiratory distress 1.0
vertigo 0.8
arthralgia 0.8
abdominal pain 0.7
starvation 0.6
dizziness 0.4
vomiting 0.3
nausea 0.1
weakness 0.0
more...
Drug
Naloxone HCl 9.9
Cilastatin 8.2
Platelet Activating Factor 8.0
Fenoprofen 7.7
Cicletanine 7.2
Valproic Acid 7.1
Fenoldopam 7.1
Nexavar 6.9
Trapidil 6.8
Aliskiren 6.6
Febuxostat 6.5
Molsidomine 6.4
Nimesulide 6.4
Surgicel 6.4
Enalaprilat 6.4
Enalaprilat 6.4
3-Methyladenine 6.3
Iodixanol 6.2
Atipamezole 6.2
Iloprost 6.2
Ethane 5.9
Olmesartan 5.9
Phosphoramidon 5.9
Captopril 5.8
Ginger 5.7
Iopamidol 5.7
Clodronate 5.6
Nebivolol 5.6
NAG 5.6
Pregnenolone 5.5
Apixaban 5.5
Levosimendan 5.4
Copaxone 5.3
Sodium valproate 5.3
Artesunate 5.2
DMSA 5.1
Tao 5.1
Coral 5.0
CIA 5.0
Dextrose 5.0
more...
Enzyme
HK2 6.8
pantetheinase 6.8
3-mercaptopyruvate sulfurtransferase 6.7
peptidylarginine deiminase 6.7
carnosinase 6.7
serine racemase 6.4
SLB 6.4
NQO2 6.0
aminopeptidase P 5.9
NAD+ oxidoreductase 5.9
arginine deiminase 5.9
sphingosine kinase 5.7
C3b inactivator 5.6
cystathionine gamma-lyase 5.6
biliverdin reductase 5.5
xanthine oxidase 5.5
renin 5.4
caspase-11 5.2
caspase-11 5.2
E-2 5.2
gamma-glutamylcysteine synthetase 5.1
caspase-3 5.0
leucine aminopeptidase 5.0
xanthine dehydrogenase 4.9
PRA 4.9
heme oxygenase 4.9
TSP-1 4.9
PHD 4.9
CGT 4.8
MIP 4.8
superoxide dismutase 4.8
polyamine oxidase 4.8
TdT 4.7
O-GlcNAc transferase 4.7
SPT 4.6
meprin 4.5
thromboxane synthase 4.5
fumarase 4.5
glutathione peroxidase 4.4
caspase-1 4.3
more...
Compound
LNO2 9.7
Gallein 9.5
Metipranolol 9.5
Gallein 9.5
Taraxasterol 9.3
Ethanethiol 8.9
Plastoquinone 8.6
Salvianolic acid A 8.5
C6H12O6 8.4
Oxypurinol 8.4
Cilastatin 8.2
Diaspirin 8.1
Dioscin 8.1
Dioscin 8.1
Fenoprofen 7.9
Diatrizoate 7.9
Notoginsenoside R1 7.9
Diatrizoate 7.9
Pimonidazole 7.8
Pimonidazole 7.8
Isoquercitrin 7.8
D-allose 7.8
DPPD 7.7
Carnosol 7.6
Polydatin 7.5
thieno[2,3-b]pyridine 7.5
Indoxyl sulfate 7.4
3-Nitrotyrosine 7.4
Dihydralazine 7.3
Caffeic acid phenethyl ester 7.3
Fenoldopam 7.2
creatinine 7.0
Sphingosine 1-phosphate 7.0
Aristolochic acid 6.9
3-Deazaneplanocin 6.9
Edaravone 6.9
Paricalcitol 6.9
Triamterene 6.9
dimethyl malonate 6.9
NIX 6.9
more...