Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0920646 (
renal ischemia
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aldehyde dehydrogenase 2 (
ALDH
2
) is an important factor in inhibiting oxidative stress and has been shown to protect against
renal ischemia
/reperfusion injury. Therefore, we hypothesized that
ALDH
2
could reduce spinal cord ischemia/reperfusion injury. Spinal cord ischemia/reperfusion injury was induced in rats using the modified Zivin's method of clamping the abdominal aorta. After successful model establishment, the agonist group was administered a daily consumption of 2.5% alcohol. At 7 days post-surgery, the Basso, Beattie, and Bresnahan score significantly increased in the agonist group compared with the spinal cord ischemia/reperfusion injury group.
ALDH
2
expression also significantly increased and the number of apoptotic cells significantly decreased in the agonist group than in the spinal cord ischemia/reperfusion injury group. Correlation analysis revealed that
ALDH
2
expression negatively correlated with the percentage of TUNEL-positive cells (
r
= -0.485,
P
< 0.01). In summary, increased
ALDH
2
expression protected the rat spinal cord against ischemia/reperfusion injury by inhibiting apoptosis.
...
PMID:Aldehyde dehydrogenase 2 overexpression inhibits neuronal apoptosis after spinal cord ischemia/reperfusion injury. 2885 1
