Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0920646 (renal ischemia)
 2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The role of the growth-hormone (GH), insulin-like growth factor-I (IGF-I) axis in the kidney has been extensively studied in recent years. To further elucidate the role for GH and IGF-I in renal regeneration, the expression of the GH-rec, IGF-I-rec and IGF-I mRNA was studied in the post-ischemic regenerating kidney and in the liver of the same rats, using a solution hybridization assay. Rats were subjected to 90 min of unilateral renal ischemia followed by reperfusion. The kidneys and livers were collected 1, 3 and 7 days after injury. Five animals were operated on in each group. An additional five animals were sham-operated and killed on day 4. In the kidney, significant alterations were found in the expression of mRNAs for the GH-rec and the IGF-rec. The GH-rec mRNA decreased significantly at day 1 (P < 0.01) to less than one-fifth of the initial value, and normalized at days 3 and 7. The IGF-rec mRNA levels increased more than three-fold at day 3 (P < 0.01) and more than five-fold at day 7 (P < 0.01). In the kidneys there was no significant alteration in the IGF-I mRNA level. In the liver, significant alteration in the level of the GH-rec mRNA was found, while the levels of IGF-rec and the IGF-I mRNA did not change significantly. The levels of GH-rec mRNA increased two-fold at day 3 (P < 0.05), while the levels were unchanged at days 1 and 7. In the early phase of renal regeneration, there is a sharp decrease in the expression of GH-rec mRNA in the kidney. This suggests that there are no direct effects on renal tissue mediated by GH in this situation. There is a significant increase in the intrarenal IGF-I-rec mRNA levels from day 3, suggesting an increased need for IGF-I during regeneration. In the liver, the concentration of GH-mRNA is increased significantly at day 3. These data show on alterations that suggest a role for these factors in renal regeneration.
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PMID:Expression of GH receptor, IGF-I receptor and IGF-I mRNA in the kidney and liver of rats recovering from unilateral renal ischemia. 1099 Apr 48

Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR) with reported gene expression in renal cell carcinoma (RCC), we asked whether those two processes do, in fact, share molecular features and regulatory mechanisms. The majority (77%) of the genes expressed in RRR and RCC were concordantly regulated, whereas only 23% were discordant (i.e., changed in opposite directions). The orchestrated processes of regeneration, involving cell proliferation and immune response, were reflected in the concordant genes. The discordant gene signature revealed processes (e.g., morphogenesis and glycolysis) and pathways (e.g., hypoxia-inducible factor and insulin-like growth factor-I) that reflect the intrinsic pathologic nature of RCC. This is the first study that compares gene expression patterns in RCC and RRR. It does so, in particular, with relation to the hypothesis that RCC resembles the wound healing processes seen in RRR. However, careful attention to the genes that are regulated in the discordant direction provides new insights into the critical differences between renal carcinogenesis and wound healing. The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia.
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PMID:Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. 1684 69