Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0920646 (
renal ischemia
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Indoleamine 2,3-dioxygenase
(
IDO
) catabolizes tryptophan to N-formyl kynurenine and has a proapoptotic role in renal tubular epithelial cells (TEC) in response to IFN-gamma and TNF-alpha in vitro. TEC produce abundant amounts of
IDO
in vitro in response to inflammation but a pathological role for
IDO
in renal injury remains unknown. We investigated the role of
IDO
in a mouse model of
renal ischemia
-reperfusion injury (IRI). IRI was induced by clamping the renal pedicle of C57BL/6 mice for 45 min at 32 degrees C. Here, we demonstrate upregulation of
IDO
in renal tissue at 2 h after reperfusion which reached maximal levels at 24 h. Inhibition of
IDO
following IRI prevented the increase in serum creatinine observed in vehicle-treated mice (86.4 +/- 25 micromol/l, n = 11) compared with mice treated with 1-methyl-D-tryptophan, a specific inhibitor of
IDO
(33.7 +/- 8.7 micromol/l, n = 10, P = 0.031). The role of
IDO
in renal IRI was further supported by results in
IDO
-KO mice which maintained normal serum creatinine levels (32.5 +/- 2.0 micromol/l, n = 6) following IRI compared with wild-type mice (123 +/- 30 micromol/l, n = 9, P = 0.008). Our data suggest that attenuation of
IDO
expression within the kidney may represent a novel strategy to reduce renal injury as a result of ischemia reperfusion.
...
PMID:Indoleamine 2,3-dioxygenase expression promotes renal ischemia-reperfusion injury. 1848 Jan 71
