Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0920646 (
renal ischemia
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BMP-7
, a member of the bone morphogenetic protein subfamily of the TGFbeta-superfamily is highly expressed in the murine kidney.
BMP-7
is involved in fetal nephron development and mesenchymal to epithelial cell differentiation. Constitutive
BMP-7
expression is found in tubular and glomerular epithelial cells of the adult kidney.
BMP-7
may play a role in physiology and pathophysiology of the adult kidney since
BMP-7
gene expression in acute
renal ischemia
is diminished and injection of recombinant
BMP-7
into rats with ischemic acute renal failure preserves renal function. In order to investigate the transcriptional regulation of
BMP-7
, this study was undertaken to clone and characterize the promoter of the murine
BMP-7
gene. A 1394 bp sequence of the 5'-flanking region of the
BMP-7
gene was isolated and subcloned. No TATA and CAAT box consensus motifs could be identified as shown for promoters of other BMPs. Using in vitro transfection assays, the 5'-flanking region revealed moderate to strong basal promoter activity. PMA increased basal
BMP-7
promoter activity. Thus
BMP-7
gene transcription might involve at least in part a PKC-dependent pathway. The cloning of a 5'-flanking region of the
BMP-7
gene should provide a useful tool for future studies on the transcriptional regulation of
BMP-7
gene expression.
...
PMID:Cloning of the 5'-flanking region of the murine bone morphogenetic protein-7 gene. 1208 77
