Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0920646 (
renal ischemia
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study aimed to novelly design and synthesize an amide derivative as a potential substitute of
celastrol
(CLT). We constituted the compound
celastrol
-glucosamine (CLG) by conjugating 1-(2-aminoethoxy)-2-glucosamine to
celastrol
(CLT) and confirmed its chemical structure by
1
H NMR,
13
C NMR, and LC-MS/MS. Then, the potential efficacy of the CLG was investigated on
renal ischemia
-reperfusion injury animal models. The results demonstrated that the decorated compound CLG could completely reverse the disease progression as same as CLT. Furthermore, the toxicity of CLG was also fully evaluated in rat blood, liver, kidney, heart, spleen, lung, and reproductive system. Compared to the performance of CLT on normal organs, CLG could remarkably maintain high safety and significantly reduce the side effects. Taken together, the CLG could keep the same efficacy as CLT while processing lower toxicity in vivo.
...
PMID:Novel Low-Toxic Derivative of Celastrol Maintains Protective Effect against Acute Renal Injury. 3002 44
