Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0920646 (renal ischemia)
 2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of constant intravenous infusion of propranolol, 1 mg/kg/h, on acute renal failure produced by 1 h occlusion of the left renal artery in the rat were investigated by clearance and micropuncture techniques. Propranolol infusion resulted in a significantly smaller rise in proximal intratubular pressure than that observed following renal ischemia in the saline-infused group. When compared with saline-infused animals, this effectwas accompanied by a significant improvement in inulin clearance without commensurate increase in renal blood flow or stop flow pressure and suggests attenuation of intratubular obstruction by the drug. A complex metabolic effect may be involved.
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PMID:Effects of propranolol on post-ischemic acute renal failure. 735 83