Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0920646 (renal ischemia)
 2,515 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the acute renal ischemia (lasting up to 24 hrs) in rabbits the serotonin level displayed similar changes in the ischemic and contralateral kidney. In the tissues under study serotonin decreased during the first fifteen minutes of ischemia; then a tendency to increase with a maximal rise in the ischemic kidney after a 60-min ischemia was seen; as to the contralateral kidney--the maximal rise occurred after a 3 hr ischemia. At the further stages of ischemia serotonin content fell again, particularly in the ischemic kidney. The blood serotonin level increased somewhat during the 60-min ischemia. An increase in the 5-hydroxyindolacetate concentration in the urine coincided with the period of decrease of the tissue serotonin content.
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PMID:[Serotonin and 5-hydroxyindolacetate during acute renal ischemia]. 122 75

Whole blood and plasma serotonin (5-HT), its major metabolite--5-hydroxyindoleacetic acid (5-HIAA), renal cortical blood flow, serum creatinine and whole blood cyclosporine A (CyA) levels were investigated in rats administered with CyA at a dose of 5 mg/kg b.w. or 10 mg/kg b.w. for 14 consecutive days. Serum creatinine remained unaltered during CyA treatment and no apparent changes in excised kidneys were found. Dose-dependent increases in whole blood and plasma 5-HT as well as whole blood 5-HIAA levels were observed. Renal cortical blood flow declined significantly and correlated inversely with whole blood 5-HT and 5-HIAA as well as with plasma 5-HT. Whole blood 5-HT was positively related to whole blood CyA levels. Taking all these data into account and considering the fact that 5-HT is a potent vasoconstrictor, a possible role of this amine in the pathogenesis of renal ischemia during CyA administration is suggested.
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PMID:Serotonergic measures in cyclosporine A treated rats. 753 26