Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0920646 (
renal ischemia
)
2,515
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A long-lasting
renal ischemia
, followed by the left renal artery clipping (two-kidney, one clip Goldblatt model in rats) led to a marked decrease in proteasome
chymotrypsin-like
activity in the ischemic kidney. This activity was, however, significantly raised upon the stimulation with an artificial 20S proteasome activator SDS (0.025%). No changes were observed in either the levels of the constitutive 20S proteasome subunit (alpha5) or of its protein activator, PA28alpha, in the kidneys by Western blot. These preliminary results indicate that an inhibition of proteasome activity may result from a dissociation of the active proteasome complexes into the inactive 20S proteasome and its endogenous activators after a long-lasting
renal ischemia
.
...
PMID:Changes in proteasome activity in the ischemic kidney of rat with experimental renovascular hypertension. 1563 41
