Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917816 (mental retardation)
 15,867 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Among 100 patients with premature synostosis of the coronal suture or of several cranial sutures there were 37 patients with problems of social adaptation. 54% of them had committed punishable offences and 22% were even recidivists. Sexual offenders with mental retardation predominated. Frontal lobe dysfunctions with increased susceptibility to environmental damages are assumed to be the basic disorder.
 ...
PMID:[Premature craniosynostosis is related to increased criminal behavior in adolescence]. 268 18

The neurobiological basis of attention-deficit hyperactivity disorder (ADHD) in tuberous sclerosis complex is still largely unknown. Cortical tubers may disrupt several brain networks that control different types of attention. Frontal lobe dysfunction due to seizures or epileptiform electroencephalographic discharges may perturb the development of brain systems that underpin attentional and hyperactive functions during a critical early stage of brain maturation. Comorbidity of attention-deficit hyperactivity disorder (ADHD) with mental retardation and autism spectrum disorders is frequent in children with tuberous sclerosis. Attention-deficit hyperactivity disorder (ADHD) may also reflect a direct effect of the abnormal genetic program. Treatment of children with tuberous sclerosis complex with combined symptoms of attention-deficit hyperactivity disorder (ADHD) and epilepsy may represent a challenge for clinicians, because antiepileptic therapy and drugs used to treat attention-deficit hyperactivity disorder (ADHD) may aggravate the clinical picture of each other.
 ...
PMID:Attention-deficit hyperactivity disorder (ADHD) and tuberous sclerosis complex. 1980 24