Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
prion protein precursor 11.6
Beta-actin-like protein 2 11.6
Urotensin 2 10.6
HEBP2 10.0
SNX32 10.0
Dopamine receptor D3 9.6
WDR27 9.6
DALRD3 9.6
FREM3 9.2
contactin-associated protein 2 9.0
HCRTR2 9.0
TMEM132E 9.0
FBXO15 8.7
Meis homeobox 1 8.7
5-hydroxytryptamine (serotonin) receptor 2C 8.7
DORA 8.7
Kue 8.6
OX2R 8.4
Voltage-gated potassium channel 8.2
SEC61B 8.1
TSHZ2 8.1
PLEKHM2 8.1
INADL 8.0
CBT 7.9
PRNP 7.9
APSS 7.9
G5PR 7.9
APBB2 7.6
OX1R 7.6
orexin 7.4
Caspr2 7.3
ATP5H 7.3
KIRREL3 7.3
REM 7.3
PSG 7.2
MPS2 7.2
MDGA1 7.1
GPR50 7.0
OX2 6.9
HNMT 6.9
CTSH 6.8
NPCR 6.8
Orexin 6.7
ZBTB38 6.6
ARHGEF9 6.6
RASD1 6.6
MATK 6.6
ADAM22 6.6
FBXL3 6.6
SORCS1 6.6
ST3GAL5 6.6
RFX3 6.6
RORB 6.6
C30 6.5
EHD3 6.5
GABRA6 6.5
BTBD9 6.5
PIPP 6.5
OPHN1 6.4
MLT1 6.4
monocarboxylate transporter 2 6.4
SYR 6.4
SLC12A5 6.3
MT2 6.3
RPL19 6.3
LGI1 6.2
dopamine receptor D3 6.2
testes-specific protease 50 6.2
CGI 6.2
CCKBR 6.2
MTNR1A 6.2
PER3 6.2
UQCRC2 6.2
orexin receptor 2 6.2
GRIA3 6.2
MM2 6.1
PRND 6.1
OXR1 6.1
CYL 6.1
MT1 6.1
more...
Disease
Intrinsic Sleep Disorders 11.6
Sleep State Misperception 11.6
Primary hypersomnia 11.6
Inadequate Sleep Hygiene 11.6
Paradoxical insomnia 11.6
Psychophysiological insomnia 11.6
Idiopathic insomnia 11.6
Septum pellucidum cyst 11.6
Nonorganic insomnia 11.6
Chronic insomnia 11.4
Primary insomnia 11.4
Other sleep disorders 10.7
Manic behavior 10.6
aggressive outburst 10.6
Agitated Depression 10.2
Delayed sleep phase 10.2
Difficulty falling asleep 10.1
Periodic Limb Movement Disorder 10.1
Insufficient sleep syndrome 10.0
disorders of initiating or maintaining sleep 10.0
BD syndrome 10.0
Confusional arousals 10.0
parasitophobia 9.6
Recurrent depressive disorder 9.6
Morvan 9.5
pressured speech 9.5
Delayed sleep phase syndrome 9.4
Sleep disturbance 9.3
sleep disorders 9.2
Dentatorubropallidoluysian atrophy 9.2
restless legs syndrome 9.1
parasomnia 9.0
Gerstmann 9.0
Drug-induced delirium 9.0
Situational anxiety 9.0
nervous exhaustion 9.0
sleep disturbances 8.9
sleep terrors 8.9
sleepwalking 8.8
racing thoughts 8.8
Blocq 8.7
Night waking 8.6
kuru 8.6
Cycloid psychoses 8.6
REM sleep behavior disorder 8.5
Workaholism 8.5
disturbed concentration 8.4
suicidal impulses 8.3
Sleep attacks 8.3
Drug-induced myopathy 8.2
APSS 8.2
narcolepsy 8.2
sCJD 8.1
Surgical menopause 8.1
Couvade 8.1
Masked depression 8.1
Mulvihill-Smith syndrome 8.0
Negativism 8.0
High altitude cerebral edema 8.0
sleep epilepsy 8.0
psychomotor impairment 7.9
FFI 7.9
Neonatal anoxia 7.7
mixed bipolar disorder 7.6
prodromal schizophrenia 7.6
Dhat syndrome 7.6
oxyuriasis 7.6
Acute mountain sickness 7.6
caffeine abuse 7.6
behavior disorder 7.5
combat fatigue 7.5
Milk allergy 7.5
menopausal syndrome 7.4
extrapyramidal disorder 7.4
CJD 7.4
paranoid state 7.3
jetlag 7.3
cataplexy 7.3
delusions of persecution 7.3
Opioid Withdrawal 7.2
more...
Symptom
insomnia 11.6
burning sensation in eye 11.6
ringing in ear 11.6
Persistent insomnia 11.6
Secondary Insomnia 11.6
Rebound insomnia 11.4
Transient insomnia 11.2
Drug withdrawal symptoms 10.6
hypersomnia 9.3
CNS symptom 9.2
Oral discomfort 9.2
unable to sleep 9.0
tactile hallucination 9.0
Biot's breathing 9.0
Poor sleep 8.9
Early morning awakening 8.7
Pain worsened 8.4
upset stomach 8.3
Withdrawal Symptom 8.2
hangover 8.2
sleepiness 8.0
feeling tired 7.9
prickling sensation 7.6
feeling exhausted 7.6
stomach cramps 7.6
hot flashes 7.5
Vaginal dryness 7.4
hot flushes 7.4
painful erections 7.3
Crawling 7.3
decreased appetite 7.3
lassitude 7.2
Psychotic Symptoms 7.2
leg cramps 7.2
feeling depressed 7.0
Tired 7.0
Cutaneous allodynia 7.0
epigastric distress 7.0
excessive sweating 7.0
Cancer Fatigue 6.9
redness of the eyes 6.8
snoring 6.8
agitation 6.8
Multiple symptoms 6.7
Myokymia 6.7
dizziness 6.7
forgetfulness 6.7
workaholic 6.7
auditory hallucination 6.7
menopausal symptoms 6.7
abnormal taste 6.6
eds 6.6
Climacteric symptoms 6.6
Intermenstrual bleeding 6.6
visual hallucination 6.5
giddiness 6.5
giddiness 6.5
vaginal itching 6.5
Sudden deafness 6.4
stomach pain 6.4
elevated mood 6.4
sinus congestion 6.2
physical exhaustion 6.2
asthenia 6.2
situational stress 6.2
dry throat 6.2
Todd's paralysis 6.2
mastalgia 6.1
lightheadedness 6.1
peri-menopausal 6.1
dysosmia 6.0
nausea 6.0
muscle cramps 6.0
sighing 6.0
physical symptom 5.9
anorexia 5.9
Hangover 5.9
Involuntary Movement 5.9
constipation 5.9
enuresis 5.9
more...
Drug
Clomipramine HCL 11.6
Contomin 11.6
Ramelteon 10.8
Pyrethia 10.6
ProSom 10.6
Hydroxyzine pamoate 10.6
Pexiganan acetate 10.6
Ambien 10.4
Indiplon 10.4
Flurazepam hydrochloride 10.2
Eszopiclone 10.2
Norgesic 10.0
Tiamenidine 10.0
Tandospirone citrate 10.0
Trazodon 9.7
Insidon 9.6
Longgu 9.3
Lormetazepam 9.2
Oxilorphan 9.0
Flurazepam 8.9
MT6 8.8
Uncaria hook 8.7
Requip 8.7
Zonisamide 8.7
Triazolam 8.7
Brotizolam 8.7
Trimipramine 8.6
Clopamide 8.6
Geodon 8.4
Focalin 8.4
Timiperone 8.4
Paliperidone palmitate 8.3
Requip 8.2
Methysergide maleate 8.2
Geodon 8.1
Lisdexamfetamine dimesylate 8.0
Diclectin 7.9
CXN 7.9
Mirtazapine 7.8
Brofaromine 7.7
Concerta 7.5
Duloxetine 7.4
Paliperidone 7.4
Sonata 7.4
Tranxene 7.3
Valpromide 7.3
Rescriptor 7.3
Catapres 7.3
Alarin 7.3
Dormicum 7.3
Moclobemide 7.2
Armodafinil 7.2
Ziprasidone hydrochloride 7.2
Mellaril 7.2
Fluvoxamine maleate 7.0
Imidafenacin 7.0
Agomelatine 7.0
Valpromide 7.0
Etizolam 7.0
Iloperidone 6.9
Penfluridol 6.9
Pramipexole 6.9
Talwin 6.9
Pramipexole 6.8
Tianma 6.8
Fampridine 6.8
Tora 6.8
Tantum 6.7
Atomoxetine 6.7
Xyrem 6.6
Reboxetine 6.6
Doxofylline 6.6
Cellcept 6.6
Cellcept 6.6
Modafinil 6.5
Diethylpropion 6.5
Rauwolfia serpentina 6.5
Proleukin 6.5
Escitalopram oxalate 6.5
Domperidone 6.3
more...
Enzyme
copalyl diphosphate synthase 5.9
acetylserotonin O-methyltransferase 5.8
MSAS 5.7
LDT 5.7
AFR 4.9
DAHP synthase 4.7
IOR 4.3
tyrosine decarboxylase 4.0
PFI 3.9
PMT 3.9
GM3 synthase 3.8
glutaryl-CoA dehydrogenase 3.8
tryptophan hydroxylase 3.8
arylalkylamine N-acetyltransferase 3.8
monoamine oxidase 3.7
SOR 3.6
MCS 3.5
GABA transaminase 3.5
SOI 3.3
dimethylarginine dimethylaminohydrolase 3.3
SOR 3.1
CYP3A4 3.0
SNO 3.0
CFI 2.9
AOR 2.8
proteinase K 2.7
BIS 2.6
Alternating 2.5
CYP27A1 2.5
SPT 2.5
GRK5 2.4
N-acetyltransferase 2.4
thyroid peroxidase 2.3
botulinum neurotoxin 2.2
NAT 2.2
monoacylglycerol lipase 2.1
SMP 2.1
ornithine aminotransferase 2.1
DAT 2.0
aldehyde oxidase 2.0
CEP 2.0
TMT 1.9
CPT 1.9
ornithine transcarbamylase 1.8
GRK2 1.8
CPT 1.8
FFT 1.8
SPT 1.7
ferrochelatase 1.7
calcium pump 1.6
acetylcholinesterase 1.5
CEP 1.4
gamma-glutamyl transpeptidase 1.4
CPT 1.4
cholinesterase 1.4
uricase 1.3
CPS 1.3
phenylalanine hydroxylase 1.1
indoleamine 2,3-dioxygenase 1.1
3-hydroxy-3-methylglutaryl coenzyme A reductase 1.0
aspartate aminotransferase 1.0
alanine aminotransferase 0.9
choline acetyltransferase 0.9
aryl hydrocarbon hydroxylase 0.9
aldehyde dehydrogenase 0.8
creatine kinase 0.7
glutaminase 0.7
DCF 0.6
BAL 0.6
CaMKII 0.6
methylenetetrahydrofolate reductase 0.5
methylenetetrahydrofolate reductase 0.5
hormone-sensitive lipase 0.5
aldehyde dehydrogenase 0.5
aldehyde dehydrogenase 0.5
aldehyde dehydrogenase 0.4
ADH 0.4
caspase-8 0.4
glutathione reductase 0.3
IKK 0.3
more...
Compound
Phenindamine 11.6
Zaleplon 10.5
Quazepam 10.1
Levomethadyl acetate 10.0
Dalmane 9.9
Zolpidem 9.6
Estazolam 9.6
7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one 9.6
3,4,5-Trimethoxycinnamic acid 9.0
Trazodone 8.9
Temazepam 8.9
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one 8.7
Valerenic acid 8.5
Trimeprazine 8.5
2,4-dichloropyrimidine 8.4
Bupropion hydrochloride 8.3
Doxylamine 8.3
cyclodecanone 8.2
Tabernanthine 8.2
Geissoschizine 8.1
Mirtazapine 8.0
cyclopropanecarboxamide 8.0
N,N-diethylacetamide 7.9
Prazepam 7.7
Isocarboxazide 7.6
Dormicum 7.6
2-phenyl-1,3-propanediol 7.6
Gelsemine 7.6
Echinocystic acid 7.5
Fastin 7.5
Fleroxacin 7.4
Decursinol 7.2
Nitrazepam 7.2
Bupropion 7.1
Diethylpropion 7.1
Sibutramine 6.8
Quetiapine 6.8
1-piperidinecarboxamide 6.7
Cadinene 6.7
Thiothixene 6.7
Tetrabenazine 6.7
Cyclobenzaprine 6.6
Rufloxacin 6.6
Kavain 6.6
Opipramol 6.6
Nefazodone 6.5
Aripiprazole 6.5
Oxazepam 6.5
Clonazepam 6.5
4-PIOL 6.5
Pseudoephedrine 6.4
Doxepin 6.4
Chlormezanone 6.4
Protriptyline 6.4
Felbamate 6.4
Lorazepam 6.4
Bromazepam 6.4
Ropinirole 6.4
Norethisterone acetate 6.3
Fluvoxamine 6.3
Nalmefene 6.2
Melatonin 6.2
Sertraline 6.1
Zyban 6.1
Ephedrine 6.1
Delavirdine 6.1
Meclizine 6.0
Paxilline 5.9
Levomepromazine 5.9
SHB 5.9
Venlafaxine 5.9
Oxolinic acid 5.8
N-phenylacetamide 5.8
THIP 5.7
Ziprasidone 5.7
Grepafloxacin 5.7
Efavirenz 5.6
Nortriptyline 5.6
HN3 5.6
Nalorphine 5.6
more...