Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 650
REM 283
prion 212
orexin 208
GABA 200
CBT 167
prion protein 162
She 108
PrP 98
Mol 89
C30 62
MRI 62
ICD 49
Gen 48
Orexin 46
PRNP 45
insulin 42
GABA(A) receptor 37
cytokine 35
5-hydroxytryptamine 35
dream 35
hemoglobin 35
Pol 34
prolactin 33
CGI 31
beta-endorphin 30
reserved 29
MT2 29
interferon 27
MT1 27
Men 27
cytochrome P450 26
ANOVA 26
CSF 26
5-HT2A 24
5-HT1A 24
ADHD 24
C-reactive protein 23
APA 21
cage 20
alkaline phosphatase 19
ferritin 19
brain-derived neurotrophic factor 19
acetylcholinesterase 19
TNF 19
CPAP 18
SWS 18
PSG 17
albumin 17
IL-6 17
CYP3A4 17
Mil 16
GSD 16
OX1R 16
ACTH 16
amyloid precursor protein 16
olfactory 16
growth hormone 15
OX2R 15
opioid receptor 15
gut 15
chronic renal failure 15
interleukin-6 15
leptin 15
Mot 15
CD4 14
tumor necrosis factor 14
GAD 14
IFN 14
FSH 13
SAS 13
lipopolysaccharide 13
axonal 13
San 13
CLOCK 13
MM2 12
alanine aminotransferase 12
superoxide dismutase 12
NMR 12
serotonin receptor 12
glutamic acid decarboxylase 12
serotonin transporter 12
calcium channel 12
aspartate aminotransferase 12
14-3-3 12
corticotropin-releasing factor 11
voltage-gated potassium channel 11
SCL 11
HDL 11
JAMA 11
SCH 10
Met 10
STOP 10
glial fibrillary acidic protein 10
FDG 10
Hop 10
MDD 10
Bright 10
dopamine transporter 10
inducible nitric oxide synthase 9
ACS 9
CYP 9
catalase 9
short form 9
CRH 9
NMDA receptor 9
HLA 8
HMG-CoA reductase 8
Clock 8
nodal 8
cannabinoid receptor 8
endoplasmic reticulum 8
14-3-3 protein 8
ART 8
COX-2 8
Cad 8
MAO-A 8
vasopressin 8
melanin-concentrating hormone 8
HPA 8
OX2 8
IgE 8
ATP 8
Caspr2 8
lactate dehydrogenase 8
P450 8
rhodanese 8
anonymous 8
Tob 8
parathyroid hormone 8
SARS 8
GSH 7
DIS 7
AIS 7
5-HT3 receptor 7
phosphodiesterase 7
ESI 7
CYP2C19 7
adrenocorticotropic hormone 7
B12 7
estrogen receptor 7
COPD 7
CYP2D6 7
substance P 7
C18 7
adenylate cyclase 7
PER1 7
polypeptide 7
tryptophan hydroxylase 7
ACT 7
erythropoietin 7
HT3 7
DORA 7
collagen 6
Pseudomonas 6
glutathione peroxidase 6
follicle-stimulating hormone 6
CO2 6
TAK 6
G protein-coupled receptor 6
more...
Disease
depression 2436
sleep disorders 1416
sleep disturbances 875
cancer 449
major depressive disorder 402
sleep apnea 365
restless legs syndrome 354
hypertension 318
obstructive sleep apnea 309
psychosis 307
dementia 288
posttraumatic stress disorder 284
mental illness 276
anxiety disorders 260
narcolepsy 256
schizophrenia 246
Parkinson's disease 223
epilepsy 217
hallucinations 215
Creutzfeldt-Jakob disease 211
diabetes 199
Alzheimer's disease 197
cognitive impairment 192
obesity 190
chronic pain 187
xerostomia 177
suicide 177
Sleep disturbance 169
addiction 136
confusion 131
stroke 123
Gerstmann 120
breast cancer 113
delirium 108
pruritus 103
cardiovascular disease 100
bipolar disorder 100
migraine 95
mania 91
psychological distress 91
movement disorder 86
sexual dysfunction 86
aggression 83
asthma 82
Chronic insomnia 81
fibromyalgia 80
delusions 80
HIV 79
alcoholism 77
neuroticism 76
affective disorder 74
substance abuse 74
ADHD 73
autism 72
memory impairment 69
anemia 65
cold 65
tumor 62
fits 62
kuru 61
multiple sclerosis 61
parasomnia 60
behavior disorder 59
rash 58
REM sleep behavior disorder 55
amnesia 55
AIDS 55
cataplexy 54
parkinsonism 54
suicide attempts 54
sleepwalking 54
Syndrome 53
spongiform encephalopathy 52
encephalitis 51
substance use 51
rumination 50
panic disorder 50
chronic obstructive pulmonary disease 50
osteoporosis 49
ICD 49
obsessive-compulsive disorder 48
scrapie 48
chronic disease 48
HAM 48
dyspepsia 48
panic attacks 47
drug addiction 46
heart failure 46
drug withdrawal 46
drug abuse 44
encephalopathy 44
emotional distress 41
GAD 41
nocturia 41
coma 41
West 41
anhedonia 40
influenza 39
Primary insomnia 38
heart disease 38
dysautonomia 38
Morvan 37
violence 37
renal disease 35
coronary heart disease 34
paranoia 33
dysthymia 33
bruxism 33
hypochondriasis 33
disorientation 33
type 2 diabetes 33
dysphoria 32
FFI 31
Disorder 31
peripheral neuropathy 31
alcohol abuse 31
CJD 30
psychological stress 30
chronic fatigue syndrome 30
osteoarthritis 29
emotional instability 28
substance use disorders 28
neuropathy 28
myocardial infarction 28
infectious diseases 28
hyperphagia 27
renal failure 27
atopic dermatitis 26
metabolic syndrome 26
lung cancer 26
SAD 26
pneumonia 26
major depressive episode 26
irritable bowel syndrome 25
neurological disease 25
alcohol use disorder 25
melancholia 24
Pineal 24
psychiatric diagnosis 24
malnutrition 24
arthritis 23
allergic rhinitis 23
chronic renal failure 23
clinical depression 23
eating disorder 22
incontinence 22
rheumatoid arthritis 22
binge eating 22
disinhibition 22
mountain sickness 21
gastroesophageal reflux disease 21
Autism 21
hepatitis C 20
chronic hepatitis 20
Cannabis 20
immunodeficiency 20
dyskinesia 20
aggressiveness 20
dysphagia 19
erectile dysfunction 19
more...
Symptom
insomnia 10606
sleepiness 1104
fatigue 990
pain 813
headache 779
nausea 499
agitation 433
dizziness 346
anorexia 279
seizures 233
vomiting 219
hypersomnia 216
constipation 199
diarrhea 191
tremor 152
dyspnea 127
weakness 121
snoring 104
discomfort 84
nausea and vomiting 80
ataxia 73
myoclonus 72
hot flushes 68
cough 67
discomfort 65
asthenia 65
tinnitus 64
hot flashes 63
back pain 63
vertigo 63
abdominal pain 63
myalgia 62
decreased appetite 60
Poor sleep 57
menopausal symptoms 56
paresthesia 53
exhaustion 50
arthralgia 49
lethargy 48
anesthesia 45
memory loss 42
dystonia 39
Ill 36
eds 35
hangover 35
apathy 34
hopelessness 33
numbness 33
enuresis 32
overweight 30
low back pain 28
analgesia 28
Depressive symptoms 26
forgetfulness 24
excessive sweating 24
spasticity 24
night sweats 22
syncope 22
bradykinesia 20
chills 20
Rebound insomnia 20
chest pain 20
dysarthria 20
acute stress 19
muscle cramps 19
Sedation 18
tingling 18
chorea 18
stigma 17
cerebellar ataxia 17
blurred vision 17
shortness of breath 17
cancer pain 15
flushing 15
hunger 15
bone pain 14
angina 14
twitching 14
stomach pain 14
lassitude 14
shoulder pain 14
bloating 13
distraction 13
nasal congestion 12
cachexia 12
lightheadedness 12
tense 11
spasm 11
dysuria 11
muscle rigidity 11
neuralgia 10
catatonia 10
dysesthesia 10
pallor 9
respiratory distress 9
tonic-clonic seizure 9
auditory hallucination 9
neck pain 9
visual hallucination 9
mastalgia 9
rhinorrhea 9
stridor 9
erythema 8
heartburn 8
Involuntary Movement 8
Persistent insomnia 8
Neuropathic pain 7
despair 7
alexithymia 7
personality change 7
abdominal discomfort 7
paresis 7
pelvic pain 7
polyuria 7
wheezing 7
dry skin 7
hypercapnia 7
bitter taste 7
leg cramps 7
hypertonia 7
photophobia 7
abdominal cramps 6
polydipsia 6
mental fatigue 6
giddiness 6
cyanosis 6
feeling tired 6
sneezing 6
hyperesthesia 6
leg pain 6
orofacial pain 6
giddiness 6
hypotonia 6
collapse 5
functional recovery 5
limb pain 5
Wind 5
Crawling 5
chronic cough 5
acute pain 5
hypothermia 5
body pain 5
physical symptom 5
CSR 5
anosmia 5
epigastric pain 4
feeling depressed 4
orthopnea 4
colic 4
Gastrointestinal symptoms 4
chest tightness 4
sciatica 4
dental pain 4
unable to sleep 4
hoarseness 4
drooling 4
physical exhaustion 4
ataxic gait 4
peri-menopausal 4
acidity 4
more...
Drug
caffeine 120
Zonisamide 54
Ramelteon 46
Triazolam 37
Spectrum 33
CSF 26
Mirtazapine 23
Flurazepam 23
Dermatol 22
Portal 19
Ambien 18
Eszopiclone 18
Domperidone 18
Duloxetine 18
Cardiovasc 16
Gabapentin 14
Asthma 14
Modafinil 12
Monit 11
Clonidine 11
Leaf 10
Brotizolam 9
Diurnal 9
Moclobemide 9
Lormetazepam 9
Pramipexole 8
Pramipexole 8
Spectrum 8
Indiplon 8
Dial 8
Donepezil 8
Agomelatine 8
Flunitrazepam 7
ACT 7
Check 7
Atomoxetine 7
Trimipramine 7
MT6 6
Paliperidone 6
Ethanol 6
TAK 6
CAM 5
Asn 5
Escitalopram 5
niacin 5
9-THC 5
Loratadine 5
Pregabalin 5
Ofloxacin 5
Dormicum 5
ascorbate 4
Ritalin 4
APD 4
Oxaliplatin 4
AZT 4
Catapres 4
Reboxetine 4
AZT 4
Trazodon 4
Lovastatin 4
nitroglycerin 4
Orlistat 4
Sonata 4
Glycyrrhiza 4
Codeine 3
Tibolone 3
Ginseng 3
Digitalis 3
vitamin E 3
Codeine 3
Acamprosate 3
Longgu 3
Alarin 3
IL-2 3
ICI 3
Reserpine 3
lysine 3
Thioridazine 3
Opium 3
Frontal 3
Paliperidone palmitate 3
Histamine 3
ROC 3
Truvada 3
OIF 3
ENT 3
Lisdexamfetamine dimesylate 3
ALA 3
Triad 3
EFV 3
TES 2
Flurazepam hydrochloride 2
OTC 2
Iloperidone 2
Pravastatin 2
Tianma 2
Uncaria hook 2
Theophylline 2
Singular 2
Zyban 2
Senna 2
CTX 2
Prozac 2
Penfluridol 2
Roflumilast 2
G-CSF 2
ROS 2
OTC 2
IFN-beta 2
Concerta 2
Diphenhydramine 2
Mazindol 2
Brofaromine 2
Dakar 2
Lugol 2
Remoxipride 2
CFS 2
Vitamin B12 2
Seroquel 2
Requip 2
Senna 2
Ritanserin 2
Estriol 2
SPP 2
Roflumilast 2
TMS 2
Requip 2
DBS 2
Rauwolfia serpentina 2
Leucovorin 2
Acyclovir 2
Phenytoin 2
Trimethoprim-sulfamethoxazole 2
Atenolol 2
Nephron 2
DEX 2
Madopar 2
Diclectin 2
Spiegel 1
Crixivan 1
Zotepine 1
Alliance 1
Aprepitant 1
Adderall 1
Tantum 1
Imatinib 1
ampicillin 1
Focalin 1
Foradil 1
Proleukin 1
Norplant 1
Vitamin E 1
CTC 1
Tocopherol 1
Indomethacin 1
Paraplatin 1
Stiripentol 1
SMP 1
Glutathione 1
Dexfenfluramine 1
more...
Enzyme
monoamine oxidase 45
acetylcholinesterase 26
ERK 20
alkaline phosphatase 19
CYP3A4 17
alanine aminotransferase 17
aspartate aminotransferase 14
superoxide dismutase 13
cholinesterase 11
catalase 11
reverse transcriptase 10
creatine kinase 10
lactate dehydrogenase 9
ACS 9
focal adhesion kinase 9
proteinase K 9
tryptophan hydroxylase 8
gamma-glutamyl transpeptidase 8
phosphodiesterase 7
adenylate cyclase 7
mitogen-activated protein kinase 7
glutathione peroxidase 6
ATPase 6
protein kinase 5
thyroid peroxidase 5
renin 4
AOR 4
P-glycoprotein 4
glutathione reductase 4
calcineurin 4
CPT 4
caspase-3 4
CPT 4
CPT 4
lipase 4
N-acetyltransferase 4
choline acetyltransferase 4
botulinum neurotoxin 3
Alternating 3
GABA transaminase 3
MCS 3
NO synthase 3
aldehyde dehydrogenase 3
arylalkylamine N-acetyltransferase 3
carbonic anhydrase 3
caspase-8 3
tyrosine hydroxylase 3
ornithine transcarbamylase 2
BIS 2
aldehyde dehydrogenase 2
AMP-activated protein kinase 2
glutathione S-transferase 2
ACE 2
SOR 2
DAT 2
PARP 2
aldehyde dehydrogenase 2
IKK 2
AMPK 2
aldehyde dehydrogenase 2
urokinase-type plasminogen activator 2
AMPK 2
phospholipase C 2
acetylserotonin O-methyltransferase 2
GRK5 2
aldehyde dehydrogenase 2
succinate dehydrogenase 2
CaMKII 2
alcohol dehydrogenase 2
peroxidase 2
PMT 2
CFI 2
LDT 2
GSK 2
hormone-sensitive lipase 1
glutaminase 1
methylenetetrahydrofolate reductase 1
IOR 1
GM3 synthase 1
CAD 1
ornithine aminotransferase 1
CEP 1
DCF 1
CPS 1
PFI 1
aryl hydrocarbon hydroxylase 1
luciferase 1
SOR 1
copalyl diphosphate synthase 1
RNA polymerase 1
AFR 1
SPT 1
phenylalanine hydroxylase 1
methylenetetrahydrofolate reductase 1
SOI 1
complex I 1
enolase 1
glyceraldehyde-3-phosphate dehydrogenase 1
MEK 1
ferrochelatase 1
calcium pump 1
SPT 1
TMT 1
CYP27A1 1
CAD 1
SMP 1
CAD 1
glucose oxidase 1
cytochrome oxidase 1
proteasome 1
AST 1
HSD 1
beta-glucuronidase 1
FFT 1
monoacylglycerol lipase 1
aldose reductase 1
glutaryl-CoA dehydrogenase 1
aldolase 1
hyaluronidase 1
BAL 1
3-hydroxy-3-methylglutaryl coenzyme A reductase 1
hyaluronidase 1
prostate-specific antigen 1
CD10 1
asparaginase 1
protein kinase C 1
hexokinase 1
ricin 1
MDR 1
indoleamine 2,3-dioxygenase 1
CEP 1
ceruloplasmin 1
tyrosinase 1
NAT 1
dimethylarginine dimethylaminohydrolase 1
tyrosine decarboxylase 1
NADPH-diaphorase 1
GRK2 1
sulfatase 1
ATP synthase 1
diamine oxidase 1
NADPH oxidase 1
NADPH oxidase 1
glyceraldehyde-3-phosphate dehydrogenase 1
phosphatidylinositol 3-kinase 1
aldehyde oxidase 1
pepsin 1
SNO 1
uricase 1
DNA polymerase 1
DAHP synthase 1
BMT 1
MSAS 1
ADH 1
Compound
Clin 1279
Dec 703
DSM 245
GABA 207
GABA 202
Melatonin 158
caffeine 120
Zolpidem 119
5-HT 110
ethanol 103
oxygen 98
water 91
sodium 88
gamma-aminobutyric acid 67
glucose 65
tryptophan 65
tryptophan 65
tryptophan 64
tryptophan 64
calcium 63
noradrenaline 61
methionine 60
DNA 45
glutamate 43
His 42
Trazodone 41
iron 40
potassium 37
creatinine 36
Zaleplon 31
Diazepam 30
acetate 29
5-hydroxytryptophan 29
Cardiol 29
Bupropion 27
valine 25
Mirtazapine 23
mercury 23
methanol 22
nitric oxide 20
Temazepam 20
acetonitrile 19
TNF 19
urea 18
Quetiapine 18
sulfate 17
hydrogen 17
ACTH 16
nitrogen 16
salt 16
Aripiprazole 16
CO2 16
phosphate 16
Midazolam 15
L-DOPA 15
Nicotine 15
CES 14
Optimal 14
Quazepam 13
Estrogen 13
Clonazepam 13
5-HTP 13
Piper 12
Lorazepam 12
5-HTP 12
Asp 12
ethyl acetate 12
tyrosine 12
Risperidone 12
aspartic acid 11
6-12 11
Malondialdehyde 11
Estrogen 11
Sertraline 11
CPA 11
Amantadine 10
galactose 10
formic acid 10
Nitrazepam 10
formic acid 10
aspartic acid 10
formic acid 10
formic acid 10
formic acid 10
formic acid 10
formic acid 10
ammonium 10
CAM 10
Olanzapine 10
formic acid 10
acetamide 10
leucine 10
aspartic acid 10
formic acid 10
aspartic acid 10
formic acid 10
acetamide 10
ACS 9
piperidine 9
ACS 9
toluene 9
Estazolam 9
copper 9
Fluvoxamine 9
piperidine 9
glutamic acid 9
carbonate 9
NMDA 9
Venlafaxine 9
EDS 8
phosphorus 8
arginine 8
Dial 8
Dopamine 8
5-HIAA 8
ATP 8
Sibutramine 8
pyridine 8
TCM 8
TCM 8
Dexamethasone 7
Thyroid 7
Dalmane 7
asparagine 7
hydroxyindoleacetic acid 7
THIP 7
GSH 7
Pac 7
Methadone 7
Mg2+ 7
GSH 7
Neuronal 7
iodine 7
acetic acid 7
Methylphenidate 7
AZT 7
MSM 6
TOF 6
zinc 6
bromide 6
Off 6
Efavirenz 6
DMS 6
Hearts 6
Amantadine 6
hexane 6
Fleroxacin 6
alanine 6
Amantadine 6
TBI 6
serine 6
glutamine 6
Paroxetine 6
Ephedrine 6
TSH 6
Amantadine 6
Citalopram 6
AMP 6
Lithium 6
cAMP 5
more...