Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When injected intraperitoneally (i.p.) into normal cats, methiothepin (1-7.5 mg/kg) or metergoline (0.5-8 mg/kg) induced total insomnia. The duration of suppression of deep slow-wave sleep (SWS2) and paradoxical sleep (PS) was dose-related for methiothepin (10-30 h), but was shorter and not dose-related for metergoline (3-5 h). When injected into the fourth ventricle, methiothepin (20 microgram) induced a selective suppression of PS for 6-7 h). In rho-chlorophenyl-alanine (PCPA)-pretreated, insomniac cats, i.p. injection of 5 mg/kg of DL-5-hydroxytryptophan(5-HTP) was followed by SWS and PS after latencies of 25 and 62 min. When methiothepin (2.5 mg/kg) or metergoline (4 mg/kg) were given before 5-HTP, the latency for the first PS episode increased dramatically to 7 h. Thereafter PS occurred periodically for 10 h but no SWS appeared. These results suggest that a 'PS factor' induced by 5-HTP and different from indolamines is preserved during the antagonistic effect of methiothepin or metergoline until it can act upon the executive mechanisms of PS. Our data also suggest that metergoline and methiothepin suppress but do not delay the mechanism responsible for SWS2 in the PCPA-5-HTP paradigm.
 ...
PMID:5-HT antagonists suppress sleep and delay its restoration after 5-HTP in p-chlorophenylalanine-pretreated cats. 621 54

Objectives. To investigate the effect of Si Ni San freeze-dried powder (SNSP) on sleep phase in insomniac and normal rats, to identify its mode of action in improving sleep, and to provide a reliable method for determining pharmacodynamic material basis of Si-Ni-San on improving sleep. Methods. Rats were deprived of sleep by using the footplate electrical stimulator to record the rats' electroencephalogram (EEG) and electromyogram (EMG) by using polysomnography (PSG) and copy insomnia model by the method of electric stimulation. Analysis on EEG and EMG was carried out to observe the effects of SNSP on the sleep phase of insomniac and normal rats. Results. Rats were treated by intragastric administration (i.g.) consecutively for seven days. The results showed that the total sleep time was extended; meanwhile, SWS2 (P < 0.01) and REMS (P < 0.05) were mainly prolonged for both insomniac and normal rats. The dates implied SNSP could significantly improve sleep. Conclusions. SNSP could prolong SWS2 and REMS, the experimental reproducibility is good, and the dates indicate that SNSP has the sedative function. Study on the effects of SNSP on sleep phases provided a basis for the further studies on effective constituents and the pharmacodynamic mechanism of SNSP.
...
PMID:The efficacy study on si ni san freeze-dried powder on sleep phase in insomniac and normal rats. 2381 36