Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The main clinical value of the EEG in psychiatry is as a non-invasive tool for the investigation of organic mental syndromes and epilepsy. Predictions that CT scanning would make the EEG redundant have not been fulfilled. Indeed, the 2 instruments complement each other, the EEG being a measure of function and the CT scan a reflection of brain structure. Both are proving useful in the investigation of dementia, providing different but complementary information about the extent and progress of the disease. Quantitative methods of EEG analysis using laboratory computers are now readily available. Significant changes in both the EEG background activity and event related potentials have been clearly demonstrated in the functional psychoses. These are not specific for any diagnostic condition. This implies that they reflect changes caused by the impact of the psychotic mental state on the individual's cognitive processes and level of arousal. The challenge for the future is to develop models of the relationship between the electrical events and underlying cognitive processes. Some progress has been made concerning the ERP changes in selective attention and in phobic disorder. The computerized EEG has a clearly established place in the investigation of drug action, by-passing the blood brain barrier and providing direct access to brain activity. Clearly this work may prove useful in the study of the effects of drug induced change on neurotransmitter systems. The EEG study of all night sleep in patients with functional psychiatric disorders has not lived up to the early expectations of workers in the field. Nevertheless the studies of insomnia and hypnotic drug effects have had valuable practical implications.
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PMID:The electroencephalogram in psychiatry: clinical and research applications. 637 4

Lamotrigine (LTG) as both effective against a wide range of seizure types and epileptic syndromes and well tolerated drug is being used in mono--as well as in polytherapy of pharmacoresistant epilepsy. The aim of this study was to evaluate the efficacy, safety and neuropsychological functioning after LTG (mean daily dose: 316 mg) as long-term monotherapy (12 mo) in 24 young adult out-patients (22.5 ys) with newly recognised and not-previously treated epilepsy in an open, non-comparative trial. 67% of patients were responders (above 50% reduction in seizure frequency) and 42% reported seizures remission. The best were results in patients with generalised convulsive fits (87% with remission). Adverse events in the early phase of medication in 21% of patients typically concerned CNS and gastrointestinal system (headache, asthenia, insomnia, nausea, gastric aches) and resolved spontaneously without treatment discontinuation. Biochemical examinations were normal and transient leucopenia and diminishion of MCV were clinically not significant. Neurodynamic abilities, neuropsychological examination results, memory verbal and visual tests and organic evaluation in organic triada tests did not show deterioration after LTG treatment. Slight difficulties in abstractive and operative thinking and some focal symptoms of fronto-temporal origin should be considered a result of drug but also the epilepsy per se. No significant differences in latencies and amplitudes of evoked potentials (VEP, BAEP, SEP and especially ERP-300) were measured after LTG. Preliminary results obtained in this study supported good efficacy and tolerability and especially lack of unfavourable influence of LTG on neuropsychological functioning in young previously untreated patients with epilepsy.
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PMID:Long-term monotherapy with lamotrigine in newly diagnosed epilepsy in adults. 1197 53

According to the neurocognitive perspective on insomnia, conditioned arousal results in impairment of information processing, as such interfering with normal sleep processes. In the present study, evening event-related potentials N100 and P200 were evaluated to assess hyperarousal in patients with insomnia and controls. 13 patients (mean age = 40.8) with polysomnographically verified sleep disruptions and 11 good sleepers (mean age = 45.4) were included. An auditory oddball paradigm was administered the evening of the polysomnography. N100 and P200 mean amplitudes and peak latencies at Fz and Cz were analyzed as a measure of respectively general arousability and inhibition of information processing. Patients experiencing insomnia were characterized by decreased P200 amplitudes compared to good sleepers. No significant differences were found for N100 amplitudes and latencies of both ERP waves. These results suggest that this group of patients with objectified insomnia is characterized by an arousal impairment. However, there was no evidence of hyperarousal, considering the normal N100 amplitudes. On the other hand, the inhibition of information processing was distorted. As such, the impairment of de-arousal or de-activation in insomnia is put forward as an additional factor within the arousal model.
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PMID:Excitatory versus inhibitory impairments in insomnia patients: an ERP study. 2354 97