Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Little is known about the effect of far-infrared rays (FIR) on serotonin and malondialdehyde levels in depressed patients with insomnia. The purpose of this study is to assess the effect of far-infrared rays on depressed people with insomnia. A randomized design was used to determine this effect. A total of 70 inpatients were recruited with the clinical diagnosis of depression with sleep disturbance. In the experimental group, FIR was applied to three chosen acupuncture points by a patch-like sticker for a period of 15 minutes twice a week. The three acupuncture points are Nei-Kuan (PC6), Shenmen (HT7) and Sanyinjiao (SP6). The total duration of experiment was four weeks. For both experimental and control groups, serum levels of serotonin (5HT) and malondialdehyde (MDA) were examined before and after the introduction of FIR. The experimental group revealed disparate changes over different dependent variables, in which serotonin increased but MDA decreased after the introduction of FIR. These observations indicate that the serotonin pathway is involved in the pathophysiological mechanism responsible for the damaging effects of MDA on depressed patients with insomnia.
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PMID:The effect on serotonin and MDA levels in depressed patients with insomnia when far-infrared rays are applied to acupoints. 1988 44

This study is a double-blind randomized controlled trial on the effect of intradermal acupuncture on insomnia after stroke. Hospitalized stroke patients with insomnia were enrolled in the study and were randomly assigned to either a real intradermal acupuncture group (RA group) or a sham acupuncture group (SA group). The RA group received intradermal acupuncture on Shen-Men (He-7) and Nei-Kuan (EH-6) for three days, and the SA group received sham acupuncture on the same points. The effect of acupuncture on insomnia was measured using Insomnia Severity Index (ISI) and Athens Insomnia Scale (AIS) at baseline and three days after treatment. To assess the effect of acupuncture on the autonomic nervous function, the subjects' blood pressure and heart rate variability were monitored. Fifty-two subjects (27 in the RA group and 25 in the SA group) were included in the final analysis. The insomnia-related scales ISI and AIS showed greater improvement of insomnia in the RA group than in the SA group. Moreover, there is a greater reduction of the number of non-dippers and a greater decrease of the LF/HF ratio (heart rate variability) in the RA group than in the SA group. These results indicate that sympathetic hyperactivities were stabilized in the RA group. It can thus be concluded that intradermal acupuncture on Shen-Men and Nei-Kuan is a useful therapeutic method for post stroke-onset insomnia as it reduces sympathetic hyperactivities.
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PMID:Intradermal acupuncture on shen-men and nei-kuan acupoints improves insomnia in stroke patients by reducing the sympathetic nervous activity: a randomized clinical trial. 1993 12

Recent years have seen a large amount of research indicating a high morbidity and mortality of cardiovascular disease (CVD) combined with insomnia, which leads to increasing attentions in studying the association between insomnia and CVD, such as coronary heart diseases, hypertension, heart failure, psycho-cardiology diseases and so on. Sufficient evidence shows that patients suffering from CVD are much more likely to get involved in insomnia than healthy persons. Furthermore, causing great troubles to patients with CVD, insomnia seriously influences the treatment process and prognosis of CVD. However, there is a lack of pragmatic direction for the diagnosis and treatment of this comorbidity. As a result, a specialized consensus statement offering guidance in diagnosing and treating CVD combined with insomnia, is in exigent need. This consensus, which is made by experienced experts from various relevant professional fields including cardiology, psychiatry, neurology, psychology and so forth, has summarized the recommendations for the concepts, epidemiology, pathophysiology mechanisms, diagnosis, management and the special approaches of traditional Chinese medicine in this comorbid conditions. In conclusion, it's certain that this consensus will contribute to the practitioners in managing CVD accompanied with insomnia.
Zhonghua Nei Ke Za Zhi 2017 Apr 01
PMID:[A consensus statement on the diagnosis and treatment of cardiovascular diseases combined with insomnia from Chinese experts]. 2835 30