Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

374 patients suffering from insomnia were divided into three groups by random: 202 cases in group I were treated with compound Suanzaoren Ansen capsules (SAC); 85 cases in group II were treated with Zhusha Ansen pills (ZAP) as control; 87 cases in group III were treated with Methaqualone (Hyminal) also as control. The therapeutic results were as follows: Groups I, II and III showed significant effective rates of 49.50%, 18.82% and 32.18% respectively; moderate effective rates of 34.65%, 48.24% and 49.43% respectively; and total rates of effectiveness of 84.15, 67.06% and 81.61% respectively. The authors found significant statistical difference between group I and II (P less than 0.005) and of no statistical difference between group I and III (P greater than 0.05). The results showed that the effects of compound SAC were better than ZAP, and similar to that of methaqualone. EEG analysis carried out while sleeping confirmed the effects mentioned above. Low toxicity (LD50 10.7 g/kg) of compound SAC was found through animal experimentations. No towards reactions were revealed in clinical trials except nausea in 3 cases. Heart rate and blood pressure changed lightly in a few cases.
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PMID:[Observation on the efficacy and experimental study of compound suanzaoren ansen capsules in insomnia]. 273 92