Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cyclobarbitone, hexobarbitone, quinalbarbitone sodium, pentobarbitone sodium, phenobarbitone sodium, nealbarbitone and a placebo have been compared in a controlled double-blind trial in twenty-four psychiatric patients with insomnia. Each of the barbiturates significantly prolonged sleep and hastened its onset. They also reduced the patients' motility, recorded by an electronic apparatus attached to the bed. There was no clear difference between these barbiturates in onset and duration of action during the 8 hr of recording; some effect upon sleep or motility was present throughout this period. Differences between compounds were of degree rather than of duration of action. Pentobarbitone, quinalbarbitone and phenobarbitone were most effective; cyclobarbitone and hexobarbitone were less effective; nealbarbitone had only a weak hypnotic action.
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PMID:A comparison of the effects of six barbiturates and a placebo on insomnia and motility in psychiatric patients. 1395 93

Pentobarbitone-induced hypnosis test was used as an animal model to explore the role of BR-16A, a polyherbal formulation in sleep. Pentobarbitone produces quick sleep latency (onset) and prolongation of total sleep time (duration). Sleep latency and total sleep time were used as a parameters for the evaluation. BR-16A potentiated the effect of triazolam (0.1 mg/kg, ip) and alprazolam (0.25 mg/kg, ip). Melatonin (5.0 mg/kg, ip) and zolpidem (0.5 mg/kg, ip) did not produce any significant effect on sleep parameters. However, alprazolam (0.25mg/kg, ip) potentiated the effect of BR-16A (100 mg/ kg, po) in higher dose only. Sleep promoting effect of BR-16A in combination with GABAergic drugs (triazolam and alprazolam,) suggested that these drugs have common mechanism in sleep promoting effect of pentobarbitone and could be used along with other GABAergic hypnotics for the treatment of insomnia. This may reduce the dose of the latter drug(s). BR-16A can be used for the treatment of sleep and sleep-related disorders.
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PMID:On the sleep promoting effects of BR-16A: interaction with GABAergic modulators. 1523 67