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Query: UMLS:C0917801 (
insomnia
)
10,606
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effects of beta-endorphin and of morphine SO4 (0.5 microgram and 2.0 microgram, respectively, injected intraventricularly) upon the sleep-wakefulness behavior of cats were examined. Both agents produced
insomnia
. Deep slow wave sleep was sharply inhibited, and rapid eye movement (REM) sleep was entirely suppressed. Light slow wave sleep, occurring in brief, isolated episodes, became the most abundant stage of sleep. The nuchal electromyogram was markedly increased after both agents.
Naloxone
(100 microgram/kg), injected subcutaneously 30 min before beta-endorphin or morphine SO4, entirely reversed these agents' effects on the two stages of slow wave sleep, and antagonized the exaggerated electromyogram. But naloxone did not counteract the REM-suppressant effect of either beta-endorphin or morphine SO4. Total sleep time reverted towards control values after naloxone pretreatment, but not entirely; the difference may be due to the persistent deficit of REM sleep. The data may indicate an involvement of an inner opioid in the regulation of sleep and wakefulness in the cat, and may point to a role for more than one endorphin receptor in the effects of opioids on the states of vigilance in cats.
...
PMID:Effects of beta-endorphin and morphine on the sleep-wakefulness behavior of cats. 627 85
Introduction:
Sleeplessness
is the most common sleep disorder. In this study, the hypnotic effect of macerated (HAME) and soxhlet (HASE) extract of
Lagenaria vulgaris
(fruit and seed) and
Cucurbita pepo
(fruit) were studied in mice.
Methods:
Extracts and fractions were administered intra-peritoneally (i.p.) in mice 30 min before the sodium pentobarbital (30 mg/kg, i.p.). Moreover, the influence of flumazenil or naloxone on the hypnotic effects of the extract and its toxic effects were evaluated.
Results:
The HAME and HASE of
C. pepo
prolonged the pentobarbital-induced sleep duration at dose of 200 mg/kg. The HAME of
L. vulgaris
(fruit) at dose of 200 mg/kg increased the sleeping time. The HAME and HASE of
L. vulgaris
(seed) increased sleep duration at doses of 50 and 100 mg/kg. Besides, flumazenil (2 mg/kg) reversed the effects of both diazepam (
P
< 0.001 vs. diazepam group), 200 mg/kg of HAME of
C. pepo
and 50 mg/kg of HAME and HASE of
L. vulgaris
(seed). All fractions especially ethyl-acetate fraction (EAF) of
L. vulgaris
(seed) increased the sleep duration.
Naloxone
reversed the hypnotic effect of HAME and HASE of
L. vulgaris
(seed). The extracts showed no neurotoxic effects on PC12 and L929 cell lines.
Conclusion:
The results showed that
L. vulgaris
(seed and fruit) and
C. pepo
potentiated pentobarbital hypnosis without toxic influence. The hypnotic effects of
L. vulgaris
seed was greater than its fruit and
C. pepo
. The GABA and opioid receptors may play role in the sleep-induction of
L. vulgaris
seed.
...
PMID:Evaluation of the Sleep-Prolonging Effect of Lagenaria vulgaris and Cucurbita pepo Extracts on Pentobarbital-Induced Sleep and Possible Mechanisms of Action. 3034 86
