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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a randomized parallel-group trial the blood-pressure lowering effect of a new beta-adrenoceptor blocker bopindolol (LT 31-200) in a dose of 1-4 mg once daily (eight patients) was compared with that of propranolol in a dose of 40-120 mg t.i.d. (nine patients). The average blood pressure fell in the bopindolol group from 185/113 mmHg to 135/90 mmHg and in the propranolol group from 183/120 mmHg to 147/102 mmHg. Both changes were statistically significant. This was achieved during a nine week treatment period at the end of which the average dose of bopindolol was 3 mg per day and of propranolol 330 mg per day. One patient receiving bopindolol interrupted the trial because of restlessness and insomnia, and one receiving propranolol because of bronchospasm. Side-effects were, otherwise, mild in both groups. During a one-year treatment period following the comparative trial, the seven patients who had received bopindolol showed no evidence of tachyphylaxia, the blood-pressure remaining well controlled while the dosage was slightly reduced. No new side-effects were reported and the ANA and AMA tests remained negative in all patients.
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PMID:Bopindolol, a new long-acting beta-adrenoceptor antagonist--a randomized comparison against propranolol in hypertensive patients. 614 12

We report the case of a 14-year-old girl who developed postural orthostatic tachycardia syndrome (POTS) with chronic fatigue 2 months following Gardasil vaccination. The patient suffered from persistent headaches, dizziness, recurrent syncope, poor motor coordination, weakness, fatigue, myalgias, numbness, tachycardia, dyspnea, visual disturbances, phonophobia, cognitive impairment, insomnia, gastrointestinal disturbances, and a weight loss of 20 pounds. The psychiatric evaluation ruled out the possibility that her symptoms were psychogenic or related to anxiety disorders. Furthermore, the patient tested positive for ANA (1:1280), lupus anticoagulant, and antiphospholipid. On clinical examination she presented livedo reticularis and was diagnosed with Raynaud's syndrome. This case fulfills the criteria for the autoimmune/auto-inflammatory syndrome induced by adjuvants (ASIA). Because human papillomavirus vaccination is universally recommended to teenagers and because POTS frequently results in long-term disabilities (as was the case in our patient), a thorough follow-up of patients who present with relevant complaints after vaccination is strongly recommended.
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PMID:Postural Orthostatic Tachycardia With Chronic Fatigue After HPV Vaccination as Part of the "Autoimmune/Auto-inflammatory Syndrome Induced by Adjuvants": Case Report and Literature Review. 2642 98