Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects upon sleep returning after an effective dose of Tabernanthine p-chlorophenoxyacetate (SAD 103) are studied on chronically implanted cats. The near-total insomnia lasting for 6-8 h provoked by SAD is characterized by a calm waking period broken by periods of drowsiness. Recuperation follows a characteristic pattern: slow-wave sleep first reappears as phasic slow-wave sleep, the duration of the phases augmenting greatly between the 12th and 18th hour, after which slow-wave sleep reappears. After having been blocked for some 10 h, paradoxical sleep is seen again, remaining, however, as does slow-wave sleep, below normal for the first 30 h. The basic mechanisms behind the stimulating effect of SAD 103 are still unknown; hypotheses derived from recent neurophysiological and neurochemical investigations on sleep are discussed.
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PMID:[Restoration of sleep in cats pretreated with tabernanthine p-chlorophenoxyacetate (SAD 103) (author's transl)]. 731 49

Volunteers from the membership of the SAD Association took part in a postal survey, before and after eight weeks' treatment with Hypericum (Kira), using an 11-item rating scale. The maximum score is 44 and the mean score in 168 patients using Kira alone was 21.3. This fell to 13 at endpoint (p < 0.001). The corresponding figures for 133 patients using Kira + light therapy were 20.6 and 11.8, respectively (p < 0.001). In both groups, there was significant improvement in anxiety, loss of libido and insomnia. There were no significant between-group differences on any measure except that improvement in sleep was greater in the Kira + light group (p < 0.01). On the results of this survey, Hypericum would appear to be an effective treatment for SAD.
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PMID:Hypericum in seasonal affective disorder (SAD). 1021 9