Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The hypnotic action and residual effects of a single bedtime dose of 7-chloro-3-hydroxy-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)one (temazepam, Planum) were investigated in young, healthy adults. Two different doses of the drug (20 or 30 mg) or placebo were administered as soft-gelatin capsules 30 min before bedtime. Motor activity was recorded by a wrist-worn activity monitor. In comparison to placebo both doses of temazepam reduced night-time motor activity, an effect that was significant only for the first half of the night. After temazepam subjects rated their sleep as deeper and more quiet. A dose of 30 mg caused increased ratings of "grogginess" in the morning and at noon. There was no evidence for rebound insomnia in the 3 nights following drug intake. The results indicate that temazepam 20 mg in young adults has a reliable hypnotic effect without significant residual sequelae.
 ...
PMID:Hypnotic action and residual effects of a single bedtime dose of temazepam. 614 16