Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

4 preparations for treating menstrual disorders were tested in a double-blind study of 171 women. Trisekvens and Gynovin were tested in 59 premenstrual women, age 34-54, who still had menstrual periods, some with irregularities. Estrofem and Geklimon were administered in a group of 112 women, age 32-69, who were definitely in the post-menopausal stage. Heat flashes and sweating improved in 88%-97% of the patients and disappeared completely in 63%-80%. Unspecific symptoms improved in 56%-69% of the patients. Menstrual cycle regularity was improved in 89% of the patients in the premenopausal group; 1 patient reported a worsening of the condition. Irregular bleeding occurred in 7.1% of the postmenopausal patients. There were no significant changes in body weight or blood pressure during the study. In 9.4% of the patients side effects such as breast tension, menstrual pain, or nausea were reported. In 15.8% of the patients newly discovered unspecific symptoms such as irregular bleeding, nervousness, or sleeplessness were reported. There were no significant differences determined between Trisekvens and Gynovin or Estrofem and Geklimon.
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PMID:[Estradiol and estriol in the treatment of climacteric symptoms. A controlled trial]. 37 43