Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Idiopathic insomnia (Childhood-onset insomnia) which belongs to Intrinsic Sleep Disorders in ICSD, has some dysfunction in sleep-wake center in brain. Sleep-wake center consists of two parts, one is sleep center which is present in the anterior parts of hypothalamus, and the other is wake center which is present in the ascending reticular activating system including posterior parts of hypothalamus. Idiopathic insomnia patients are said to have hyperactivity in wake center or hypoactivity in sleep center. And these patients have sleep disturbances such as inability to fall asleep, frequent awakenings and early morning wakefulness. Most patients have sleep disturbances from their childhood and after the onset of sleep disturbances, these disturbances show no improvement during all their life. Concerning about the drug treatment, probably benzodiazepin or barbiturate are effective. Because of long-term use of drugs, drug dependence and tolerance are often observed in patients. So it is necessary to take special care when choosing type or dosage level of drugs.
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PMID:[Idiopathic insomnia]. 950 35

Sleeping disturbance constitutes a major problem occurring in 25% of people aged over 65. Among the most frequent reasons of insomnia one can mention the overuse of coffee, alcohol, smoking, using some drugs, stress, depression, neurosis, dementia, chronic diseases. Idiopathic insomnia constitutes less than 5% of cases. Before the treatment of insomnia is started, its cause should be found and it should be determined if it is transient or chronic. The treatment of insomnia can be based on pharmacotherapy and non-pharmacotherapy methods. Behavioural therapy is mentioned among non-pharmacotherapeutic methods. It aims at changing the sleep-related habits. Pharmacotherapeutic treatment (still mostly based on benzodiazepines) should not last longer than 2-3 weeks and drugs of short elimination T 1/2 (below 6 hours) should be used. Side-effects of this group of drugs should always be taken into consideration. It should be remembered that sleep disturbances can be symptoms of other diseases and their treatment cannot consist in prescribing hypnotics only.
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PMID:Sleeping disturbances and pharmacological/nonpharmacological interventions in old people. 1289 70