Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
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The psychometric properties of the Beck Inventory (BI), a revised, copyrighted version of the Beck Depression Inventory (BDI), were investigated in 204 university students. Two-week test-retest reliability was .90, coefficient alpha was .87, concurrent validity using the BDI as the criterion was .94, and the correlation between level of depression as measured by the two instruments was .86. The mean score on the BI was significantly but only one-half point lower than that on the BDI. Individual items were all highly and significantly correlated, but a significantly lower BI mean score occurred on the Sadness, Suicidal Ideas and Insomnia items. Depression was not significantly related to demographic variables.
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PMID:The Beck Inventory: psychometric properties in university students. 404 89

Interferon-alpha (IFN-alpha) is the only effective treatment for chronic hepatitis B and C. Over 2/3 of methadone-substituted patients suffer from chronic hepatitis C but a history of psychiatric disorders or drug addiction is still seen as a contraindication for IFN-alpha because of a possible increased risk of severe psychiatric side effects such as depression, suicide attempts or psychotic episodes. We report on the case of a 33-year-old patient with chronic hepatitis C and a positive psychiatric history (drug abuse, borderline personality and four suicide attempts). After 4 months of therapy with IFN-alpha he developed a psychosis with persecution mania, complex thought disorder, disturbance of sexual identity, sleeplessness, anxiety, depression and increased irritability with suicidal thoughts. Symptoms did not disappear after discontinuation of interferon treatment. To our knowledge, there are no other reports of persistent psychosis with a possible association to interferon treatment. Development of psychosis and other psychiatric side-effects may be an indication of possible neuromodulatory effects of IFN-alpha with long-term treatment. On the other hand, the treatment for hepatitis C was successful. Ideas for safer treatment in methadone patients with psychiatric co-morbidity and chronic hepatitis C are needed.
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PMID:Psychosis in a methadone-substituted patient during interferon-alpha treatment of hepatitis C. 1096 74