Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The introduction of a computerized medical information system as part of a project assessing quality in primary care required the coding of drugs prescribed. The development of a simple four-digit system is described, coding drug, therapeutic class, and route of administration. The system allows easy measurement of the use of combined preparations.The drugs used for insomnia and acute bronchitis have been analysed. The results show marked variation with the age of the patient.The potential for medical audit is discussed as it is now possible to link prescribing figures in routine primary care with relevant clinical information.
 ...
PMID:Analysis of primary care prescribing--a "constructive" coding system for drugs. 31 Aug 81

Triiodothyronine (T3) administration to patients suffering from chronic bronchial asthma or patients suffering from nasopharyngeal allergy was reported to ameliorate the attacks. Twelve patients aged less than 35 years suffering from chronic bronchial asthma for more than 5 years, who were maintained on usual anti-asthmatic drugs with the exception of steroids and chromoglycate and who were not the subject of repeated attacks of bronchitis were chosen for the study. Each patient was given T3 orally as 40 micron/day divided into two doses, for a period of 60 days. The drug increased the peak flow in all cases. The increase averaged 24.6% +/- 8.48 (P less than 0.001). Three cases reported marked improvement and four were able to reduce the dose of anti-asthmatic drugs. There was no significant change in the pulse rate, ECG, body weight, blood pressure, or appetite. One patient complained of insomnia and another of increased anxiety. It is possible that T3 exerts its beneficial effect through correcting the level of C-AMP, which is known to be low in asthmatics, through improvement of body mechanism for antibody formation, or through other unidentified mechanisms.
 ...
PMID:Effect of triiodothyronine on bronchial asthma. II. 90 44

One hundred and thirteen patients who were treated at the Kyushu University Hospital and other related hospitals were randomly assigned to 2 groups to compare the effect of twice daily administration of 200 mg each and that of 300 mg each of ofloxacin (OFLX). The patients included 41 cases with pneumonia, 18 with acute bronchitis, 33 with chronic bronchitis, 15 with bronchiectasis with infection, 3 with diffused panbronchiolitis, and 3 with other secondary infectious diseases. Fifty-five cases were administered 400 mg OFLX a day and 58 cases received 600 mg. The number of severe cases in the 600 mg group was greater than that in the 400 mg group. The ratios of general amelioration of clinical symptoms were 92.6% in the 400 mg group and 82.1% in the 600 mg group. Thus, the ratio of the 400 mg group was better than that of the 600 mg group. However, the ratio of significant amelioration in the 600 mg group was 35.7% which was better than that in the 400 mg group, 27.8%. For bacteriological effects the rate of disappearance and decrease in number of bacteria was 92% in the 400 mg group and was significantly better than that of the 600 mg group, 70%. The incidence of side effects in the 600 mg group was 22.4% and this was high in contrast to that in the 400 mg group, 3.6%. Most of the side effects in the 600 mg group involved symptoms of the central nervous system such as sleeplessness. No significant differences were observed in incidences of abnormalities of laboratory tests at 1.8% and 1.7%, respectively. Safety in the 400 mg group were 96.4% which was significantly higher in number than those in the 600 mg group, 77.6%. Efficacy rates of twice daily administrations each with 200 mg and 300 mg OFLX for lower respiratory infections were 94.4 and 79.3%, respectively. In conclusion, the daily dose of 400 mg was the most effective.
 ...
PMID:[Clinical studies on the utility of ofloxacin for lower respiratory infections]. 204 Nov 47

To contribute more comprehensive information about the characteristics of asthma, this article analyzed patients served by the University of Alabama at Birmingham Comprehensive Asthma Program. Their physicians rated one fifth of these patients as having "severe" asthma with the remainder about equally divided between "moderate" and "mild". One in two first received a diagnosis of asthma ten or more years previously. Common comorbidities were hypertension, obesity, rhinitis, bronchitis, sinusitis, and arthritis. One half had visited an emergency room or been hospitalized for asthma in the past year. Inhaled bronchodilators and continuous theophylline were the most commonly prescribed medications. Side effects, especially tachycardia and insomnia, were common and almost exclusively associated with theophylline or corticosteroid therapy. Spirometric assessment showed chronic airflow obstruction in those with more severe asthma. Prevalence of respiratory symptoms, intensity of medication regimen, incidence of side effects, and health care utilization increased as asthma severity increased.
 ...
PMID:Characteristics and correlates of asthma in a university clinic population. 220 37

The data presented in this paper examine the frequent statements that the regular use of the drug qat by the people of North Yemen is harmful to their health. The research strategy employed performance of blind physical examinations as well as extensive interviews with 335 females and 371 males in and around the cities of Sanaa, Taiz and Hodeida who had been selected using a quota sample. The sample was classified into heavy, light and non-chewers of the qat plant, and systematic comparisons were made. In general, few diseases or conditions occurred with enough frequency to permit detailed analysis and fewer yet were associated with qat-use. Where associations occurred, differences by sex were often strong. Conditions most strongly associated with use by both sexes were histories of gastritis and insomnia, and the general body system groupings of gastrointestinal disorders. In males the strongest associations were with the histories of anorexia, constipation, insomnia and headaches, as well as the general history of respiratory difficulties. In females strong associations were seen between qat-use and the diagnosis of acute gastritis, and histories of jaundice, bronchitis and hepatic diseases. When effects of age and residence were corrected for by Mantel-Haenszel odds ratios on these items, some of the associations were diminished even further. In general, remarkably few of the allegations regarding the direct effects of qat-use on health by Western visitors to Yemen were supported by this study.
 ...
PMID:A medical evaluation of the use of qat in North Yemen. 687 37

This article reviews recent studies conducted in Europe which sought to evaluate the effectiveness of Peter Mandel's Esogetic Colorpuncture Therapy (ECT). These investigations addressed the use of specific ECT therapies for treating a variety of difficult health problems: migraines, childhood insomnia, bronchitis, ADD or learning disorders, and uterine fibroids. Limitations in research design and sample size necessitate that these studies be viewed as pilot or preliminary research. However, in all the studies, the findings showed dramatic improvement of symptoms after ECT treatments. This suggests that ECT may offer fast, economical, non-invasive and non-toxic methods for treating the selected health problems and that ECT continues to show promise as a powerful new method of wholistic healing.
 ...
PMID:A review of recent research studies on the efficacy of Esogetic Colorpuncture Therapy--A wholistic acu-light system. 1051 1

Generalized resistance to disease and reduced tendency to depression have been related to the extent of social relationships, with a greater association for females than males. Cigaret smoking is the largest cause of preventable death: smokers' mortality rates are almost double those for non-smokers. Coronary heart disease and lung cancer are the main causes of death. Morbidity is also higher among smokers, who are more prone to bronchitis, emphysema, sinusitis, peptic ulcers, and influenza. Abuse of drugs, both prescribed and unprescribed, is linked directly to drug dependency and death, often suicide. Misuse of prescribed drugs is a major concern in the elderly. High caffeine consumption has been related to chronic insomnia, persistent anxiety and depression, and stomach upset. Use of properly adjusted seatbelts halves the number of deaths and the severity of injury in motor vehicle accidents. Type A personality behaviors are associated with an increased risk of coronary heart disease. "Insight" requires further study to assess its affect on health and wellbeing. Quality of working life is an important determinant of an individual's identity and health status: frequency of symptoms increase as job strain increases.
 ...
PMID:Health consequences of selected lifestyle factors: a review of the evidence, part 2. 2127 53

Pilot epidemiology survey has been conducted with the aim to study the effect of occupational factors on workers in the Zestafoni Manganese Processing Plant. Overall 102 workers have been surveyed. They were selected from the list circulating in the plant ambulance. Selected workers have been surveyed through a standard questionnaire. The survey revealed that prevalence of such diseases as Radiculitis, hypertension, bronchitis, gastritis, and ulcer, ocular and nasal-pharyngeal diseases are high among the workers of the Zestafoni Processing Plant. Study results have shown direct correlation between development of diseases and distance residence from the plant. Prevalence of hypertension, ocular and nasal-pharyngeal diseases, bronchitis was higher among workers lived within distance of 2-5 kilometers from the plant. Positive correlation revealed between length of job and prevalence of bronchitis, ocular diseases, Radiculitis, hypertension, cardiac diseases and gastritis. Among plant workers revealed high prevalence of symptoms characterized the central nervous system disorders such as sleep disorder, insomnia, backache, walking disorders. The results proven correlation between occupational factors and diseases and different symptoms.
 ...
PMID:Environmental safety risk research. 2152 42

Ganoderma lucidum (Lingzhi or Reishi) is known as a bitter mushroom with remarkable health benefits. The active constituents found in mushrooms include polysaccharides, dietary fibers, oligosaccharides, triterpenoids, peptides and proteins, alcohols and phenols, mineral elements (such as zinc, copper, iodine, selenium, and iron), vitamins, and amino acids. The bioactive components found in the G. lucidum mushroom have numerous health properties to treat diseased conditions such as hepatopathy, chronic hepatitis, nephritis, hypertension, hyperlipemia, arthritis, neurasthenia, insomnia, bronchitis, asthma, gastric ulcers, atherosclerosis, leukopenia, diabetes, anorexia, and cancer. In spite of the voluminous literature available, G. lucidum is used mostly as an immune enhancer and a health supplement, not therapeutically. This review discusses the therapeutic potential of G. luidum to attract the scientific community to consider its therapeutic application where it can be worth pursuing.
 ...
PMID:Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. 2355 65