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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Over the past 60 years a great progress has been made in our understanding of the pathogenesis of essential hypertension. The contribution of excessive sympathetic nerves activity in the development of hypertension and target organ damage has been demonstrated in experimental and clinical studies. Also the important role of the renin-angiotensin-aldosteron in the pathophysiology of arterial hypertension has been confirmed in many studies. During the last three decades many studies revealed the relationship between low birth weight and arterial hypertension. Sleep disturbances--short sleep duration, insomnia are proposed as a possible pathophysiological factor of hypertension. The novel concept that immune system may play an important role in the pathogenesis of essential hypertension has gained support in recent years. The multifactorial nature of essential hypertension is now widely accepted.
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PMID:[Pathogenesis of essential hypertension--a half of the century perspective]. 2464 70

Prospective memory (PM) is essential in everyday life because it concerns the ability to remember to perform an intended action in the future. This ability could be influenced by poor sleep quality, the role of which, however, is still being debated. To examine the role of sleep quality in PM in depth, we decided to perform a retrospective naturalistic study examining different clinical populations with a primary sleep disorder or comorbid low sleep quality. If sleep is important for PM function, we could expect poor sleep to affect PM performance tasks both directly and indirectly. We examined a total of 3600 nights, recorded using actigraphy in participants belonging to the following groups: primary insomnia (731 nights); narcolepsy type 1 (1069 nights); attention deficit hyperactivity disorder (152 nights in children and 239 in adults); severe obesity (232 nights); essential hypertension (226 nights); menopause (143 nights); healthy controls (808 nights). In a naturalistic activity-based PM task, each participant originally wore an actigraph around the non-dominant wrist and was requested to push the event-marker button at two specific times of day: bedtime (activity 1) and get-up time (activity 2). Each clinical group showed significantly lower sleep quality in comparison to the control group. However, only narcolepsy type 1 patients presented a significantly impaired PM performance at get-up time, remembering to push the event-marker button around half the time compared not only to healthy controls but also to the other clinical groups. Overall, the present results seem to point to sleep quality having no effect on the efficiency of a naturalistic activity-based PM task. Moreover, the data indicated that narcolepsy type 1 patients may show a disease-specific cognitive deficit of PM.
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PMID:Sleep and Prospective Memory: A Retrospective Study in Different Clinical Populations. 3284 72


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