Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917801 (insomnia)
 10,606 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The electrocardiogram (ECG) of a 56-year-old woman suffering from insomnia and nervousness revealed left bundle branch block, an ECG two years previously having been normal. Echocardiography showed a perimyocardial space-occupying lesion in the area of the left ventricle. Magnetic resonance imaging demonstrated a 6 x 6 x 7 cm solid tumour, which could not be separated from the myocardium of the dorsal portion of the ventricle and the left atrial wall. Coronary angiography demonstrated a few small atypical vessels originating from the right coronary artery. An endomyocardial biopsy was equivocal. An exploratory thoracotomy revealed a large, livid tumour which could not be resected because it involved a large area of the left ventricle and left atrium. Surgical biopsy showed a cavernous haemangioma. The subsequent course (ten months' follow-up) has so far been unremarkable.
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PMID:[Left bundle-branch block and primary benign heart tumor]. 198 75

While insomnia is a familiar management problem for most doctors, disorders of hypersomnolence are much less familiar. The evolution of sleep monitoring at a major South African teaching hospital is described and the classification of sleep disorders reviewed. Analysis of the first 5 years' experience revealed that 27 of 46 patients had sleep apnoea (all obstructive, but 13 with a central component), while 3 had narcolepsy. Contributing causes of sleep apnoea included obesity (25 patients), tonsillar enlargement (3), acromegaly (3), rheumatoid cervical spondylosis (1), Hunter's syndrome (1) and haemangioma of the throat (1). Death from sleep apnoea occurred in 3 cases. Treatment of specific causes was effective in abolishing sleep apnoea, although attempts at weight loss were effective in a minority only. Nasal continuous positive airway pressure was effective in achieving symptomatic relief. Sleep monitoring was found to be valuable, provided all-night study facilities are available, and provided that patients who simply snore are excluded by prior clinical evaluation.
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PMID:The diagnosis and management of respiratory sleep disorders--the first 5 years at Groote Schuur Hospital. 225 27