Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
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Target Concepts:
Gene/Protein
Disease
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Query: UMLS:C0917798 (
cerebral ischemia
)
17,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Oligodendrocyte progenitor cells (OPCs) mature to oligodendrocyte and remyelinate axons. OPCs express
neuron-glial antigen 2
(
NG2
) chondroitin sulfate proteoglycan. We stained
NG2
to investigate the effect of aging on the OPCs after
cerebral ischemia
.
NG2
positive cells were examined at 1, 3, 7 days after 90 min of transient middle cerebral artery occlusion in young and aged brains. The number of
NG2
positive cells increased in the ischemic penumbra at 3 and 7 days after reperfusion. At 7 day, the number of
NG2
positive cells was significantly greater in the young than the aged brains, and the processes of
NG2
positive cells enlarged and were more highly branched in the young than the aged brains. These results suggest that the young brain shows a higher potential of proliferation and process branching of OPCs than the aged brain.
...
PMID:Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. 1475 32
