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Target Concepts:
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Query: UMLS:C0917798 (
cerebral ischemia
)
17,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Aquaporin-9
(
AQP9
) is a new member of the aquaporin family of water-selective channels mainly expressed in liver and testis, presenting the characteristic of also being permeable to various solutes, particularly lactate. Recent data have shown the presence of
AQP9
on tanycytes in the rat brain. In the current study, the authors show the expression of
AQP9
in astrocytes in the mouse brain and changes in its expression after
cerebral ischemia
. Indeed, in control mouse, the
AQP9
immunolabeling is present on astrocytic processes bordering the subarachnoid space and ventricles. The labeling also is observed on astrocytes in the white matter, hippocampus, hypothalamus, and lateral septum. After focal transient ischemia, an increase of the immunolabeling is detected on astrocytes in periinfarct areas. This
AQP9
distribution study in mouse brain suggests a role of
AQP9
in water homeostasis in the central nervous system. Furthermore, the overexpression of
AQP9
on astrocytes surrounding an ischemic lesion suggests that
AQP9
may also play a role in the regulation of postischemia edema and, in view of its permeability to monocarboxylates, in the clearance of lactate from the ischemic focus.
...
PMID:Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia. 1133 57
