Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0917798 (cerebral ischemia)
 17,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study offers a clinico-theoretical, electrophysiological and rheoencephalographic analysis of the brain matter condition and the cerebral hemodynamics of patients with acute cerebral circulation disorders which resolve with a complete clinical recovery. The purposes of the study were (1) to achieve pathogenetic differentiation of the syndromes of transient ischemic attacks (TIA) and reversible ischemic neurologic deficit (RIND) with greater confidence than that achieved by using the clinical criterion of "the neurologic deficit duration" (24 hours for TIAs, three weeks for RIND). (2) to determine the subclinical level in a single case, and (3) to develop a new approach to secondary prophylaxis in such patients. Fifty four patients (30 men and 24 women, mean age 57.2 +/- 1.9 years) presenting with acute ischemic disorders of cerebral circulation at the Clinic of Vascular Cerebral Diseases in the Department of Neurology of Plovdiv Medical University were followed up in the period between 1989 and 1991. On the 5th and 20th days of the episode onset the central latency time (CLT) of an evoked motor potential (MEP) was investigated on the symptomatic and asymptomatic sides. The study also involved rheoencephalography not only of the clinically followed-up population but also of 59 outpatients with TIA, 129 patients with RIND and 38 patients with an ischemic cerebral stroke. The results obtained objectify the differences among the researchers and confirm their views on the most common pathogenetic mechanisms associated with the occurrence and the course of the two forms of cerebral ischemia terminating with a complete clinical recovery.
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PMID:Pathogenetic aspects of clinico-electrophysiological differentiation of transient cerebral circulation disorders terminating with a complete clinical recovery. 819 99

In the neurosurgical field, the evoked potential is employed for the monitoring of intraoperative nerve function. During evoked potential monitoring, surgical manipulation-related nerve dysfunction is detected, and functional localization/nerves in the cerebral cortex are identified to prevent postoperative neurological complications. It is important to reduce the contact resistance to 2 kOmega or less on the application of plate electrodes used for recording and prevent noise by bundling electrode leads, to ensure a stable evoked potential during surgery. In our laboratory, intraoperative monitoring, such as ABR to prevent auditory disturbance, SEP to detect cerebral ischemia, cortical SEP and MEP to prevent motor paralysis, and evoked electromyography to identify/maintain the cranial nerves including the facial, trigeminal, oculomotor, and abducens nerves, is performed based on requests from the Department of Neurosurgery.
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PMID:[Evoked potential monitoring in an operation of neurosurgery]. 1864 33

Monitoring of transcranial electrical motor evoked potentials (tcMEP) during carotid endarterectomy (CEA) has been shown to effectively detect intraoperative cerebral ischemia. The unique purpose of this study was to evaluate changes of MEP amplitude (AMP), area under the curve (AUC) and signal morphology (MOR) as additional MEP warning criteria for clamping-associated ischemia during CEA. Therefore, the primary outcome was the number of MEP alerts (AMP, AUC and MOR) in the patients without postoperative motor deficit (false positives). We retrospectively reviewed data from 571 patients who received CEA under general anesthesia. Monitoring of somatosensory evoked potentials (SSEP) and tcMEP was performed in all cases (all-or-none MEP warning criteria). The percentages of false positives (primary parameter) of AMP, AUC and MOR were evaluated according to the postoperative motor outcome. In the cohort of 562 patients, we found significant SSEP/MEP changes in 56 patients (9.96%). In 44 cases (7.83%) a shunt was inserted. Nine patients (1.57%) were excluded due to MEP recording failure. False positives were registered for AMP, AUC and MOR changes in 121 (24.01%), 148 (29.36%) and 165 (32.74%) patients, respectively. In combination of AMP/AUC and AMP/AUC/MOR false positives were found in 9.52% and 9.33% of the patients. This study is the first to evaluate the correctness of the MEP warning criteria AMP, AUC and MOR with regard to false positive monitoring results in the context of CEA. All additional MEP warning criteria investigated produced an unacceptably high number of false positives and therefore may not be useful in carotid surgery for adequate detection of clamping-associated ischemia.
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PMID:Warning criteria for MEP monitoring during carotid endarterectomy: a retrospective study of 571 patients. 3126 9