Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0917798 (
cerebral ischemia
)
17,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Estradiol exerts a neuroprotective effect against focal cerebral ischemic injury through the inhibition of apoptotic signals.
Phosphoprotein enriched in astrocytes 15
(
PEA-15
) is mainly expressed in brain that perform anti-apoptotic functions. This study investigated whether estradiol modulates the expression of
PEA-15
and two phosphorylated forms of
PEA-15
(Ser 104 and Ser 116) in middle cerebral artery occlusion (MCAO)-induced injury and glutamate exposure-induced neuronal cell death. Adult female rats were ovariectomized to remove endogenous estradiol and treated with vehicle or estradiol prior to MCAO. Focal
cerebral ischemia
was induced by MCAO and cerebral cortices were collected 24 h after MCAO. Western blot analysis indicated that estradiol prevents the MCAO-induced decrease in
PEA-15
, phospho-
PEA-15
(Ser 104), phospho-
PEA-15
(Ser 116). Glutamate exposure induced a reduction in
PEA-15
, phospho-
PEA-15
(Ser 104), phospho-
PEA-15
(Ser 116) in cultured neurons, whereas estradiol treatment attenuated the glutamate toxicity-induced decrease in the expression of these proteins. It has been known that phosphorylation of
PEA-15
is an important step in carrying out its anti-apoptotic function. Thus, these findings suggest that the regulation of
PEA-15
phosphorylation by estradiol contributes to the neuroprotective function of estradiol in ischemic brain injury.
...
PMID:Estradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injury. 2580 82
