Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917798 (cerebral ischemia)
 17,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Surgical reconstruction of the carotid artery using a synthetic graft is rarely performed. A 71-year-old woman developed hoarseness and was diagnosed as having thyroid cancer. Computed tomography (CT) and angiography revealed an irregular thyroid tumor invading the left common carotid artery, and encasement of the artery by the tumor. Left common carotid angiography showed an irregularity of the common carotid artery wall and a dense tumor stain fed by the superior thyroid artery. Dissection of the thyroid cancer from the common carotid artery was judged to be impossible during surgery, so resection of the whole tumor together with the common carotid artery was carried out. The left common carotid artery was reconstructed using an expanded polytetrafluoroethylene (ePTFE) graft. No cerebral ischemia was evident after surgery. Postoperative CT and magnetic resonance angiography demonstrated patency of the carotid artery, and no tumor recurrence was confirmed at a 27-month follow up. The ePTFE graft appears to be a suitable synthetic graft for reconstruction of the carotid artery.
 ...
PMID:[Surgical reconstruction of the common carotid artery by an ePTFE graft for invasive thyroid cancer: a case report]. 1459 48

Although the presence of aggressive angioinvasion is not a contraindication for surgical treatment of well-differentiated thyroid cancer, surgical resection and reconstruction of the major arteries in the neck and mediastinum using a synthetic graft is rarely performed. We present our experience of resection and reconstruction of the major arteries in the neck for the treatment of locally advanced thyroid cancer. A 66-year-old woman presented with locally advanced thyroid cancer with invasion of the right internal jugular vein and vagus nerve. The cancer mass encased the junction of the right common carotid artery, the subclavian artery, and the brachiocephalic trunk. After en-bloc resection of the tumor, the arteries were reconstructed using a Y-shaped synthetic graft between the common carotid artery, aorta, and the subclavian artery. Postoperatively, there was no evidence of cerebral ischemia and the patient made a rapid recovery without complications. An aggressive surgical approach is appropriate for grossly invasive thyroid cancer to decrease the risk of local recurrence and increase survival. Surgical resection and reconstruction of the major arteries in the neck and chest using a synthetic graft can be an acceptable therapeutic option for locally advanced thyroid cancer.
 ...
PMID:Treatment of locally advanced thyroid cancer invading the great vessels using a Y-shaped graft bypass. 2023 11