Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0917798 (cerebral ischemia)
 17,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A patient is reported in whom a classic amnesic syndrome developed as a result of repeated episodes of cerebral ischaemia, accompanied by seizures. The amnesia was very severe for both old and newly acquired memories and the critical lesions defined by MRI were circumscribed areas confined to CA1 and CA2 fields of both hippocampi.
 ...
PMID:Bilateral lesions of CA1 and CA2 fields of the hippocampus are sufficient to cause a severe amnesic syndrome in humans. 760 20

Transient global amnesia (TGA) is an acute amnestic syndrome without neurological symptoms and remitting spontaneously. Though cerebral ischemia, epilepsy, and migraine have been implicated in some cases, non of these factors could be proven responsible for most, and etiology remains unclear. Of special interest is the induction of TGA by psychological and emotional stress in about 14-29% of all cases, which is illustrated by the clinical example of a 72-year-old women who suffered an attack of TGA after discovering a burglary in her home. Psychopathological and pathogenetic aspects are discussed in the context of recent neurobiological memory research. This suggests that TGA involves transient dysfunction of a specific memory subsystem associated with hippocampal structures. Neural network modelling explains the syndrome of TGA on a pathogenetic basis allowing for heterogeneous etiology and even for psychogenic release. Thus TGA serves as a model for pathogenetic explanation in the neuro-psychiatric borderland.
 ...
PMID:[Transitory global amnesia--psychogenic origin of organic disease? Psychopathologic basis and pathogenetic considerations]. 958 75

Unilateral cerebral ischemia of the hippocampus is very rare. This paper reviews the literature and presents the case of a 59-year-old woman with an amnestic syndrome due to a left hippocampal stroke. The patient suffered from retrograde amnesia which was most severe over the 2 days prior to presenting and a slight anterograde amnesia. In addition, a verbal memory disorder was confirmed 1 week after admission by neurological tests. As risk factors, arterial hypertension and a relative hyper-beta lipoproteinemia were found. This case shows that unilateral amnestic stroke, e.g. in the hippocampus region, may be the cause of an amnestic syndrome and should be included in the differential diagnostics.
...
PMID:[Hippocampal stroke]. 2557 32